{
  "schema_version": 1,
  "kind": "drug_profile",
  "generic": "thiamine",
  "review_status": "reviewed",
  "origin": "openfda",
  "sections": {
    "adult": [
      {
        "text": "In the treatment of beriberi, 10 mg to 20 mg of thiamine hydrochloride are given IM 3 times daily for as long as 2 weeks.",
        "source": "US FDA label for thiamine (Thiamine Hydrochloride), section 'dosage and administration', retrieved 2026-08-29",
        "cached_file": "labels/thiamine.json",
        "verbatim": true
      },
      {
        "text": "(See WARNINGS regarding repeated injection of thiamine.) An oral therapeutic multivitamin preparation containing 5 mg to 10 mg thiamine, administered daily for one month, is recommended to achieve body tissue saturation.",
        "source": "US FDA label for thiamine (Thiamine Hydrochloride), section 'dosage and administration', retrieved 2026-08-29",
        "cached_file": "labels/thiamine.json",
        "verbatim": true
      },
      {
        "text": "Patients with neuritis of pregnancy in whom vomiting is severe enough to preclude adequate oral therapy should receive 5 mg to 10 mg of thiamine hydrochloride IM daily.",
        "source": "US FDA label for thiamine (Thiamine Hydrochloride), section 'dosage and administration', retrieved 2026-08-29",
        "cached_file": "labels/thiamine.json",
        "verbatim": true
      }
    ],
    "child": [
      {
        "text": "“Wet” beriberi with myocardial failure must be treated as an emergency cardiac condition, and thiamine must be administered slowly by the IV route in this situation (see WARNINGS ). In the treatment of beriberi, 10 mg to 20 mg of thiamine hydrochloride are given IM 3 times daily for as long as 2 weeks.",
        "source": "US FDA label for thiamine (Thiamine Hydrochloride), section 'dosage and administration', retrieved 2026-08-29",
        "cached_file": "labels/thiamine.json",
        "verbatim": true
      },
      {
        "text": "Infantile beriberi that is mild may respond to oral therapy, but if collapse occurs, doses of 25 mg may cautiously be given IV.",
        "source": "US FDA label for thiamine (Thiamine Hydrochloride), section 'dosage and administration', retrieved 2026-08-29",
        "cached_file": "labels/thiamine.json",
        "verbatim": true
      }
    ],
    "renal": [
      {
        "text": "No kidney-impairment dose in this label. Not a statement that none is needed.",
        "source": "Read and found silent: the US FDA label for thiamine (Thiamine Hydrochloride), retrieved 2026-08-29",
        "cached_file": "labels/thiamine.json",
        "verbatim": false
      }
    ],
    "hepatic": [
      {
        "text": "No liver-impairment dose in this label. Not a statement that none is needed.",
        "source": "Read and found silent: the US FDA label for thiamine (Thiamine Hydrochloride), retrieved 2026-08-29",
        "cached_file": "labels/thiamine.json",
        "verbatim": false
      }
    ],
    "pregnancy": [
      {
        "text": "Usage in Pregnancy Studies in pregnant women have not shown that thiamine hydrochloride increases the risk of fetal abnormalities if administered during pregnancy.",
        "source": "US FDA label for thiamine (Thiamine Hydrochloride), section 'pregnancy', retrieved 2026-08-29",
        "cached_file": "labels/thiamine.json",
        "verbatim": true
      },
      {
        "text": "If the drug is used during pregnancy, the possibility of fetal harm appears remote.",
        "source": "US FDA label for thiamine (Thiamine Hydrochloride), section 'pregnancy', retrieved 2026-08-29",
        "cached_file": "labels/thiamine.json",
        "verbatim": true
      },
      {
        "text": "Because studies cannot rule out the possibility of harm however, thiamine hydrochloride should be used during pregnancy only if clearly needed.",
        "source": "US FDA label for thiamine (Thiamine Hydrochloride), section 'pregnancy', retrieved 2026-08-29",
        "cached_file": "labels/thiamine.json",
        "verbatim": true
      }
    ],
    "lactation": [
      {
        "text": "It is not known whether this drug is excreted in human milk.",
        "source": "US FDA label for thiamine (Thiamine Hydrochloride), section 'nursing mothers', retrieved 2026-08-29",
        "cached_file": "labels/thiamine.json",
        "verbatim": true
      },
      {
        "text": "Because many drugs are excreted in human milk, caution should be exercised when thiamine hydrochloride is administered to a nursing mother.",
        "source": "US FDA label for thiamine (Thiamine Hydrochloride), section 'nursing mothers', retrieved 2026-08-29",
        "cached_file": "labels/thiamine.json",
        "verbatim": true
      }
    ]
  },
  "verdicts": {
    "pregnancy": {
      "level": "caution",
      "line": "The label allows it only when the benefit is judged to outweigh the risk. Read the quote below.",
      "set_by": "Set from the label's own words, not from a reading of them: 'should be used during pregnancy only if'."
    },
    "lactation": {
      "level": "caution",
      "line": "The label allows it only when the benefit is judged to outweigh the risk. Read the quote below.",
      "set_by": "Set from the label's own words, not from a reading of them: 'caution should be exercised when thiamine hydrochloride is administered to a nursing'."
    }
  }
}