{
  "schema_version": 1,
  "kind": "drug_profile",
  "generic": "midodrine",
  "review_status": "reviewed",
  "origin": "openfda",
  "sections": {
    "adult": [
      {
        "text": "The recommended dose of midodrine hydrochloride tablets is 10 mg, 3 times daily.",
        "source": "US FDA label for midodrine (Midodrine Hydrochloride), section 'dosage and administration', retrieved 2026-08-29",
        "cached_file": "labels/midodrine.json",
        "verbatim": true
      },
      {
        "text": "Single doses as high as 20 mg have been given to patients, but severe and persistent systolic supine hypertension occurs at a high rate (about 45%) at this dose.",
        "source": "US FDA label for midodrine (Midodrine Hydrochloride), section 'dosage and administration', retrieved 2026-08-29",
        "cached_file": "labels/midodrine.json",
        "verbatim": true
      },
      {
        "text": "Total daily doses greater than 30 mg have been tolerated by some patients, but their safety and usefulness have not been studied systematically or established.",
        "source": "US FDA label for midodrine (Midodrine Hydrochloride), section 'dosage and administration', retrieved 2026-08-29",
        "cached_file": "labels/midodrine.json",
        "verbatim": true
      }
    ],
    "child": [
      {
        "text": "Safety and effectiveness in pediatric patients have not been established.",
        "source": "US FDA label for midodrine (Midodrine Hydrochloride), section 'pediatric use', retrieved 2026-08-29",
        "cached_file": "labels/midodrine.json",
        "verbatim": true
      },
      {
        "text": "The recommended dose of midodrine hydrochloride tablets is 10 mg, 3 times daily. Dosing should take place during the daytime hours when the patient needs to be upright, pursuing the activities of daily living. A suggested dosing schedule of approximately 4-hour intervals is as follows: shortly before, or upon arising in the morning, midday and late afternoon (not later than 6 P.M.).",
        "source": "US FDA label for midodrine (Midodrine Hydrochloride), section 'dosage and administration', retrieved 2026-08-29",
        "cached_file": "labels/midodrine.json",
        "verbatim": true
      }
    ],
    "renal": [
      {
        "text": "No kidney-impairment dose in this label. Not a statement that none is needed.",
        "source": "Read and found silent: the US FDA label for midodrine (Midodrine Hydrochloride), retrieved 2026-08-29",
        "cached_file": "labels/midodrine.json",
        "verbatim": false
      }
    ],
    "hepatic": [
      {
        "text": "No liver-impairment dose in this label. Not a statement that none is needed.",
        "source": "Read and found silent: the US FDA label for midodrine (Midodrine Hydrochloride), retrieved 2026-08-29",
        "cached_file": "labels/midodrine.json",
        "verbatim": false
      }
    ],
    "pregnancy": [
      {
        "text": "Midodrine hydrochloride increased the rate of embryo resorption, reduced fetal body weight in rats and rabbits, and decreased fetal survival in rabbits when given in doses 13 (rat) and 7 (rabbit) times the maximum human dose based on body surface area (mg/m 2 ).",
        "source": "US FDA label for midodrine (Midodrine Hydrochloride), section 'pregnancy', retrieved 2026-08-29",
        "cached_file": "labels/midodrine.json",
        "verbatim": true
      },
      {
        "text": "There are no adequate and well-controlled studies in pregnant women.",
        "source": "US FDA label for midodrine (Midodrine Hydrochloride), section 'pregnancy', retrieved 2026-08-29",
        "cached_file": "labels/midodrine.json",
        "verbatim": true
      },
      {
        "text": "Midodrine hydrochloride should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.",
        "source": "US FDA label for midodrine (Midodrine Hydrochloride), section 'pregnancy', retrieved 2026-08-29",
        "cached_file": "labels/midodrine.json",
        "verbatim": true
      }
    ],
    "lactation": [
      {
        "text": "It is not known whether this drug is excreted in human milk.",
        "source": "US FDA label for midodrine (Midodrine Hydrochloride), section 'nursing mothers', retrieved 2026-08-29",
        "cached_file": "labels/midodrine.json",
        "verbatim": true
      },
      {
        "text": "Because many drugs are excreted in human milk, caution should be exercised when midodrine hydrochloride is administered to a nursing woman.",
        "source": "US FDA label for midodrine (Midodrine Hydrochloride), section 'nursing mothers', retrieved 2026-08-29",
        "cached_file": "labels/midodrine.json",
        "verbatim": true
      }
    ]
  },
  "verdicts": {
    "pregnancy": {
      "level": "caution",
      "line": "The label allows it only when the benefit is judged to outweigh the risk. Read the quote below.",
      "set_by": "Set from the label's own words, not from a reading of them: 'should be used during pregnancy only if'."
    },
    "lactation": {
      "level": "caution",
      "line": "The label allows it only when the benefit is judged to outweigh the risk. Read the quote below.",
      "set_by": "Set from the label's own words, not from a reading of them: 'caution should be exercised when midodrine hydrochloride is administered to a nursing'."
    }
  }
}