Midodrine

DRUG INFORMATION

  ADULT
    - The recommended dose of midodrine hydrochloride tablets is 10 mg, 3 times daily.
      Source: US FDA label for midodrine (Midodrine Hydrochloride), section 'dosage and
      administration', retrieved 2026-08-29
    - Single doses as high as 20 mg have been given to patients, but severe and
      persistent systolic supine hypertension occurs at a high rate (about 45%) at this
      dose.
      Source: US FDA label for midodrine (Midodrine Hydrochloride), section 'dosage and
      administration', retrieved 2026-08-29
    - Total daily doses greater than 30 mg have been tolerated by some patients, but
      their safety and usefulness have not been studied systematically or established.
      Source: US FDA label for midodrine (Midodrine Hydrochloride), section 'dosage and
      administration', retrieved 2026-08-29

  CHILD
    - Safety and effectiveness in pediatric patients have not been established.
      Source: US FDA label for midodrine (Midodrine Hydrochloride), section 'pediatric
      use', retrieved 2026-08-29
    - The recommended dose of midodrine hydrochloride tablets is 10 mg, 3 times daily.
      Dosing should take place during the daytime hours when the patient needs to be
      upright, pursuing the activities of daily living. A suggested dosing schedule of
      approximately 4-hour intervals is as follows: shortly before, or upon arising in
      the morning, midday and late afternoon (not later than 6 P.M.).
      Source: US FDA label for midodrine (Midodrine Hydrochloride), section 'dosage and
      administration', retrieved 2026-08-29

  RENAL IMPAIRMENT
    - No kidney-impairment dose in this label. Not a statement that none is needed.
      Source: Read and found silent: the US FDA label for midodrine (Midodrine
      Hydrochloride), retrieved 2026-08-29

  HEPATIC IMPAIRMENT
    - No liver-impairment dose in this label. Not a statement that none is needed.
      Source: Read and found silent: the US FDA label for midodrine (Midodrine
      Hydrochloride), retrieved 2026-08-29

  PREGNANCY   [ CAUTION ]
    The label allows it only when the benefit is judged to outweigh the risk. Read the
      quote below.
    - Midodrine hydrochloride increased the rate of embryo resorption, reduced fetal
      body weight in rats and rabbits, and decreased fetal survival in rabbits when
      given in doses 13 (rat) and 7 (rabbit) times the maximum human dose based on body
      surface area (mg/m 2 ).
      Source: US FDA label for midodrine (Midodrine Hydrochloride), section 'pregnancy',
      retrieved 2026-08-29
    - There are no adequate and well-controlled studies in pregnant women.
      Source: US FDA label for midodrine (Midodrine Hydrochloride), section 'pregnancy',
      retrieved 2026-08-29
    - Midodrine hydrochloride should be used during pregnancy only if the potential
      benefit justifies the potential risk to the fetus.
      Source: US FDA label for midodrine (Midodrine Hydrochloride), section 'pregnancy',
      retrieved 2026-08-29

  BREASTFEEDING   [ CAUTION ]
    The label allows it only when the benefit is judged to outweigh the risk. Read the
      quote below.
    - It is not known whether this drug is excreted in human milk.
      Source: US FDA label for midodrine (Midodrine Hydrochloride), section 'nursing
      mothers', retrieved 2026-08-29
    - Because many drugs are excreted in human milk, caution should be exercised when
      midodrine hydrochloride is administered to a nursing woman.
      Source: US FDA label for midodrine (Midodrine Hydrochloride), section 'nursing
      mothers', retrieved 2026-08-29