Ibuprofen

DRUG INFORMATION

  ADULT
    - Rheumatoid arthritis and osteoarthritis, including flare-ups of chronic disease
      Suggested Dosage: 1200 mg-3200 mg daily (400 mg, 600 mg or 800 mg tid or qid).
      Source: US FDA label for ibuprofen (Ibuprofen), section 'dosage and
      administration', retrieved 2026-08-29
    - Individual patients may show a better response to 3200 mg daily, as compared with
      2400 mg, although in well-controlled clinical trials patients on 3200 mg did not
      show a better mean response in terms of efficacy.
      Source: US FDA label for ibuprofen (Ibuprofen), section 'dosage and
      administration', retrieved 2026-08-29
    - Therefore, when treating patients with 3200 mg/ day, the physician should observe
      sufficient increased clinical benefits to offset potential increased risk.
      Source: US FDA label for ibuprofen (Ibuprofen), section 'dosage and
      administration', retrieved 2026-08-29

  CHILD
    - Safety and effectiveness of Ibuprofen tablets in pediatric patients have not been
      established.
      Source: US FDA label for ibuprofen (Ibuprofen), section 'pediatric use', retrieved
      2026-08-29

  RENAL IMPAIRMENT
    - No kidney-impairment dose in this label. Not a statement that none is needed.
      Source: Read and found silent: the US FDA label for ibuprofen (Ibuprofen),
      retrieved 2026-08-29

  HEPATIC IMPAIRMENT
    - No liver-impairment dose in this label. Not a statement that none is needed.
      Source: Read and found silent: the US FDA label for ibuprofen (Ibuprofen),
      retrieved 2026-08-29

  PREGNANCY
    - Risk Summary Use of NSAIDs, including Ibuprofen tablets, can cause premature
      closure of the fetal ductus arteriosus and fetal renal dysfunction leading to
      oligohydramnios and, in some cases, neonatal renal impairment.
      Source: US FDA label for ibuprofen (Ibuprofen), section 'pregnancy', retrieved
      2026-08-29
    - Because of these risks, limit dose and duration of Ibuprofen tablets use between
      about 20 and 30 weeks of gestation, and avoid Ibuprofen tablets use at about 30
      weeks of gestation and later in pregnancy [see WARNINGS; Fetal Toxicity ].
      Source: US FDA label for ibuprofen (Ibuprofen), section 'pregnancy', retrieved
      2026-08-29
    - Premature Closure of Fetal Ductus Arteriosus Use of NSAIDs, including Ibuprofen
      tablets, at about 30 weeks gestation or later in pregnancy increases the risk of
      premature closure of the fetal ductus arteriosus.
      Source: US FDA label for ibuprofen (Ibuprofen), section 'pregnancy', retrieved
      2026-08-29

  BREASTFEEDING
    - It is not known whether this drug is excreted in human milk.
      Source: US FDA label for ibuprofen (Ibuprofen), section 'nursing mothers',
      retrieved 2026-08-29
    - Because many drugs are excreted in human-milk and because of the potential for
      serious adverse reactions in nursing infants from Ibuprofen tablets, a decision
      should be made whether to discontinue nursing or discontinue the drug, taking into
      account the importance of the drug to the mother.
      Source: US FDA label for ibuprofen (Ibuprofen), section 'nursing mothers',
      retrieved 2026-08-29