# Fluconazole ```text DRUG INFORMATION ADULT - Oropharyngeal candidiasis: The recommended dosage of fluconazole for oropharyngeal candidiasis is 200 mg on the first day, followed by 100 mg once daily. Source: US FDA label for fluconazole (Fluconazole), section 'dosage and administration', retrieved 2026-08-29 - Esophageal candidiasis: The recommended dosage of fluconazole for esophageal candidiasis is 200 mg on the first day, followed by 100 mg once daily. Source: US FDA label for fluconazole (Fluconazole), section 'dosage and administration', retrieved 2026-08-29 - Doses up to 400 mg/day may be used, based on medical judgment of the patient's response to therapy. Source: US FDA label for fluconazole (Fluconazole), section 'dosage and administration', retrieved 2026-08-29 CHILD - Use in Pediatric Patients for the Treatment of Oropharyngeal Candidiasis An open- label, randomized, controlled trial has shown fluconazole to be effective in the treatment of oropharyngeal candidiasis in pediatric patients 6 months to 13 years of age. Source: US FDA label for fluconazole (Fluconazole), section 'pediatric use', retrieved 2026-08-29 - Dosage and Administration in Adults Multiple Dose SINCE ORAL ABSORPTION IS RAPID AND ALMOST COMPLETE, THE DAILY DOSE OF FLUCONAZOLE IS THE SAME FOR ORAL AND INTRAVENOUS ADMINISTRATION. In general, a loading dose of twice the daily dose is recommended on the first day of therapy to result in plasma concentrations close to steady-state by the second day of therapy. Source: US FDA label for fluconazole (Fluconazole), section 'dosage and administration', retrieved 2026-08-29 - The safety profile of fluconazole in children has been studied in 577 pediatric patients from 1 day to 17 years of age who received doses ranging from 1 to 15 mg/kg/day for 1 to 1,616 days. Source: US FDA label for fluconazole (Fluconazole), section 'pediatric use', retrieved 2026-08-29 RENAL IMPAIRMENT - After the loading dose, the daily dose (according to indication) should be based on the following summary: Creatinine Clearance (mL/min) Recommended Dose (%) >50 100 ≤50 (no dialysis) 50 Hemodialysis 100% after each hemodialysis Patients on hemodialysis should receive 100% of the recommended dose after each hemodialysis; on non-dialysis days, patients should receive a reduced dose according to their creatinine clearance. Source: US FDA label for fluconazole (Fluconazole), section 'dosage and administration', retrieved 2026-08-29 - The following formula may be used to estimate creatinine clearance in pediatric patients: K × linear length or height (cm) serum creatinine (mg/100 mL) (Where K=0.55 for pediatric patients older than 1 year and 0.45 for infants.) Administration Fluconazole in Sodium Chloride Injection, USP may be administered by intravenous infusion. Source: US FDA label for fluconazole (Fluconazole), section 'dosage and administration', retrieved 2026-08-29 HEPATIC IMPAIRMENT - No liver-impairment dose in this label. Not a statement that none is needed. Source: Read and found silent: the US FDA label for fluconazole (Fluconazole), retrieved 2026-08-29 PREGNANCY - Potential for Fetal Harm: Use in pregnancy should be avoided except in patients with severe or potentially life-threatening fungal infections in whom fluconazole may be used if the anticipated benefit outweighs the possible risk to the fetus. Source: US FDA label for fluconazole (Fluconazole), section 'pregnancy', retrieved 2026-08-29 - A few published case reports describe a pattern of distinct congenital anomalies in infants exposed in utero to high dose maternal fluconazole (400 to 800 mg/day) during most or all of the first trimester. Source: US FDA label for fluconazole (Fluconazole), section 'pregnancy', retrieved 2026-08-29 - These reported anomalies are similar to those seen in animal studies. Source: US FDA label for fluconazole (Fluconazole), section 'pregnancy', retrieved 2026-08-29 BREASTFEEDING - Fluconazole was present in low levels in breast milk following administration of a single 150 mg dose, based on data from a study in 10 breastfeeding women who temporarily or permanently discontinued breastfeeding 5 days to 19 months postpartum. Source: US FDA label for fluconazole (Fluconazole), section 'nursing mothers', retrieved 2026-08-29 - The estimated daily infant dose of fluconazole from breast milk (assuming mean milk consumption of 150 mL/kg/day) based on the mean peak milk concentration (2.61 mcg/mL [range: 1.57 to 3.65 mcg/mL] at 5.2 hours post-dose) was 0.39 mg/kg/day, which is approximately 13% of the recommended pediatric dose for oropharyngeal candidiasis. Source: US FDA label for fluconazole (Fluconazole), section 'nursing mothers', retrieved 2026-08-29 - (Labeled pediatric dose is 6 mg/kg/day on the first day followed by 3 mg/kg/day; estimated infant dose is 13% of 3 mg/kg/day maintenance dose). Source: US FDA label for fluconazole (Fluconazole), section 'nursing mothers', retrieved 2026-08-29 ``` --- Dawaa Reference is a reference for prescribers, not a medical device, and does not replace clinical judgement. [Privacy policy](/privacy)