{
  "schema_version": 1,
  "kind": "drug_profile",
  "generic": "estradiol valerate",
  "review_status": "reviewed",
  "origin": "openfda",
  "sections": {
    "adult": [
      {
        "text": "Since the 40 mg potency provides a high concentration in a small volume, particular care should be observed to administer the full dose.",
        "source": "US FDA label for estradiol valerate (Estradiol valerate), section 'dosage and administration', retrieved 2026-08-29",
        "cached_file": "labels/estradiol-valerate.json",
        "verbatim": true
      },
      {
        "text": "The usual dosage is 10 to 20 mg Estradiol valerate injection, USP every four weeks.",
        "source": "US FDA label for estradiol valerate (Estradiol valerate), section 'dosage and administration', retrieved 2026-08-29",
        "cached_file": "labels/estradiol-valerate.json",
        "verbatim": true
      },
      {
        "text": "The usual dosage is 30 mg or more administered every one or two weeks.",
        "source": "US FDA label for estradiol valerate (Estradiol valerate), section 'dosage and administration', retrieved 2026-08-29",
        "cached_file": "labels/estradiol-valerate.json",
        "verbatim": true
      }
    ],
    "child": [
      {
        "text": "H. Pediatric Use Safety and effectiveness in pediatric patients have not been established. Large and repeated doses of estrogen over an extended period of time may accelerate epiphyseal closure. Therefore, periodic monitoring of bone maturation and effects on epiphyseal centers is recommended in patients in whom bone growth is not complete.",
        "source": "US FDA label for estradiol valerate (Estradiol valerate), section 'pediatric use', retrieved 2026-08-29",
        "cached_file": "labels/estradiol-valerate.json",
        "verbatim": true
      }
    ],
    "renal": [
      {
        "text": "No kidney-impairment dose in this label. Not a statement that none is needed.",
        "source": "Read and found silent: the US FDA label for estradiol valerate (Estradiol valerate), retrieved 2026-08-29",
        "cached_file": "labels/estradiol-valerate.json",
        "verbatim": false
      }
    ],
    "hepatic": [
      {
        "text": "No liver-impairment dose in this label. Not a statement that none is needed.",
        "source": "Read and found silent: the US FDA label for estradiol valerate (Estradiol valerate), retrieved 2026-08-29",
        "cached_file": "labels/estradiol-valerate.json",
        "verbatim": false
      }
    ],
    "pregnancy": [
      {
        "text": "Pregnancy Estradiol valerate injection, USP should not be used during pregnancy.",
        "source": "US FDA label for estradiol valerate (Estradiol valerate), section 'pregnancy', retrieved 2026-08-29",
        "cached_file": "labels/estradiol-valerate.json",
        "verbatim": true
      }
    ],
    "lactation": [
      {
        "text": "Nursing Mothers Estrogen administration to nursing mothers has been shown to decrease the quantity and quality of the milk.",
        "source": "US FDA label for estradiol valerate (Estradiol valerate), section 'nursing mothers', retrieved 2026-08-29",
        "cached_file": "labels/estradiol-valerate.json",
        "verbatim": true
      },
      {
        "text": "Detectable amounts of estrogens have been identified in the milk of mothers receiving this drug.",
        "source": "US FDA label for estradiol valerate (Estradiol valerate), section 'nursing mothers', retrieved 2026-08-29",
        "cached_file": "labels/estradiol-valerate.json",
        "verbatim": true
      },
      {
        "text": "Caution should be exercised when Estradiol valerate injection, USP is administered to a nursing woman.",
        "source": "US FDA label for estradiol valerate (Estradiol valerate), section 'nursing mothers', retrieved 2026-08-29",
        "cached_file": "labels/estradiol-valerate.json",
        "verbatim": true
      }
    ]
  },
  "verdicts": {
    "pregnancy": {
      "level": "avoid",
      "line": "The label says not to use it. Read the quote below before deciding.",
      "set_by": "Set from the label's own words, not from a reading of them: 'should not be used during pregnan'."
    },
    "lactation": {
      "level": "caution",
      "line": "The label allows it only when the benefit is judged to outweigh the risk. Read the quote below.",
      "set_by": "Set from the label's own words, not from a reading of them: 'Caution should be exercised when Estradiol valerate injection, USP is administered to a nursing'."
    }
  }
}