{
  "schema_version": 1,
  "kind": "drug_profile",
  "generic": "cefdinir",
  "review_status": "reviewed",
  "origin": "openfda",
  "sections": {
    "adult": [
      {
        "text": "Patients With Renal Insufficiency For adult patients with creatinine clearance < 30 mL/min, the dose of cefdinir should be 300 mg given once daily.",
        "source": "US FDA label for cefdinir (Cefdinir), section 'dosage and administration', retrieved 2026-08-29",
        "cached_file": "labels/cefdinir.json",
        "verbatim": true
      },
      {
        "text": "In patients maintained on chronic hemodialysis, the recommended initial dosage regimen is a 300 mg or 7 mg/kg dose every other day.",
        "source": "US FDA label for cefdinir (Cefdinir), section 'dosage and administration', retrieved 2026-08-29",
        "cached_file": "labels/cefdinir.json",
        "verbatim": true
      },
      {
        "text": "Subsequent doses (300 mg or 7 mg/kg) are then administered every other day.",
        "source": "US FDA label for cefdinir (Cefdinir), section 'dosage and administration', retrieved 2026-08-29",
        "cached_file": "labels/cefdinir.json",
        "verbatim": true
      }
    ],
    "child": [
      {
        "text": "Safety and efficacy in neonates and infants less than 6 months of age have not been established. Use of cefdinir for the treatment of acute maxillary sinusitis in pediatric patients (age 6 months through 12 years) is supported by evidence from adequate and well-controlled studies in adults and adolescents, the similar pathophysiology of acute sinusitis in adult and pediatric patients, and comparative pharmacokinetic data in the pediatric population.",
        "source": "US FDA label for cefdinir (Cefdinir), section 'pediatric use', retrieved 2026-08-29",
        "cached_file": "labels/cefdinir.json",
        "verbatim": true
      },
      {
        "text": "(See INDICATIONS AND USAGE for Indicated Pathogens.) Powder for Oral Suspension The recommended dosage and duration of treatment for infections in pediatric patients are described in the following chart; the total daily dose for all infections is 14 mg/kg, up to a maximum dose of 600 mg per day. Once-daily dosing for 10 days is as effective as BID dosing.",
        "source": "US FDA label for cefdinir (Cefdinir), section 'dosage and administration', retrieved 2026-08-29",
        "cached_file": "labels/cefdinir.json",
        "verbatim": true
      },
      {
        "text": "(See INDICATIONS AND USAGE for Indicated Pathogens.) Powder for Oral Suspension The recommended dosage and duration of treatment for infections in pediatric patients are described in the following chart; the total daily dose for all infections is 14 mg/kg, up to a maximum dose of 600 mg per day.",
        "source": "US FDA label for cefdinir (Cefdinir), section 'dosage and administration', retrieved 2026-08-29",
        "cached_file": "labels/cefdinir.json",
        "verbatim": true
      }
    ],
    "renal": [
      {
        "text": "Patients With Renal Insufficiency For adult patients with creatinine clearance < 30 mL/min, the dose of cefdinir should be 300 mg given once daily.",
        "source": "US FDA label for cefdinir (Cefdinir), section 'dosage and administration', retrieved 2026-08-29",
        "cached_file": "labels/cefdinir.json",
        "verbatim": true
      },
      {
        "text": "Creatinine clearance is difficult to measure in outpatients.",
        "source": "US FDA label for cefdinir (Cefdinir), section 'dosage and administration', retrieved 2026-08-29",
        "cached_file": "labels/cefdinir.json",
        "verbatim": true
      },
      {
        "text": "However, the following formula may be used to estimate creatinine clearance (CL cr ) in adult patients.",
        "source": "US FDA label for cefdinir (Cefdinir), section 'dosage and administration', retrieved 2026-08-29",
        "cached_file": "labels/cefdinir.json",
        "verbatim": true
      }
    ],
    "hepatic": [
      {
        "text": "No liver-impairment dose in this label. Not a statement that none is needed.",
        "source": "Read and found silent: the US FDA label for cefdinir (Cefdinir), retrieved 2026-08-29",
        "cached_file": "labels/cefdinir.json",
        "verbatim": false
      }
    ],
    "pregnancy": [
      {
        "text": "Teratogenic Effects Cefdinir was not teratogenic in rats at oral doses up to 1000 mg/kg/day (70 times the human dose based on mg/kg/day, 11 times based on mg/m 2 /day) or in rabbits at oral doses up to 10 mg/kg/day (0.7 times the human dose based on mg/kg/day, 0.23 times based on mg/m 2 /day).",
        "source": "US FDA label for cefdinir (Cefdinir), section 'pregnancy', retrieved 2026-08-29",
        "cached_file": "labels/cefdinir.json",
        "verbatim": true
      },
      {
        "text": "Maternal toxicity (decreased body weight gain) was observed in rabbits at the maximum tolerated dose of 10 mg/kg/day without adverse effects on offspring.",
        "source": "US FDA label for cefdinir (Cefdinir), section 'pregnancy', retrieved 2026-08-29",
        "cached_file": "labels/cefdinir.json",
        "verbatim": true
      },
      {
        "text": "Decreased body weight occurred in rat fetuses at ≥ 100 mg/kg/day, and in rat offspring at ≥ 32 mg/kg/day.",
        "source": "US FDA label for cefdinir (Cefdinir), section 'pregnancy', retrieved 2026-08-29",
        "cached_file": "labels/cefdinir.json",
        "verbatim": true
      }
    ],
    "lactation": [
      {
        "text": "Following administration of single 600 mg doses, cefdinir was not detected in human breast milk.",
        "source": "US FDA label for cefdinir (Cefdinir), section 'nursing mothers', retrieved 2026-08-29",
        "cached_file": "labels/cefdinir.json",
        "verbatim": true
      }
    ]
  }
}