# Cefazolin ```text DRUG INFORMATION ADULT - Site and Type of Infection Dose Frequency Moderate to severe infections 500 mg to 1 gram every 6 to 8 hours Mild infections caused by susceptible gram-positive cocci 250 mg to 500 mg every 8 hours Acute, uncomplicated urinary tract infections 1 gram every 12 hours Pneumococcal pneumonia 500 mg every 12 hours Severe, life- threatening infections (e.g., endocarditis, septicemia) In rare instances, doses of up to 12 grams of cefazolin per day have been used. Source: US FDA label for cefazolin (Cefazolin), section 'dosage and administration', retrieved 2026-08-29 - For lengthy operative procedures (e.g., 2 hours or more), 500 mg to 1 gram IV or IM during surgery (administration modified depending on the duration of the operative procedure). 500 mg to 1 gram IV or IM every 6 to 8 hours for 24 hours postoperatively. Source: US FDA label for cefazolin (Cefazolin), section 'dosage and administration', retrieved 2026-08-29 - Total daily dosage may be increased to 100 mg per kg (45 mg per pound) of body weight for severe infections. Source: US FDA label for cefazolin (Cefazolin), section 'dosage and administration', retrieved 2026-08-29 CHILD - Safety and effectiveness for use in premature infants and neonates have not been established. See Dosage and Administration (2.4) for recommended dosage in pediatric patients older than 1 month. Source: US FDA label for cefazolin (Cefazolin), section 'pediatric use', retrieved 2026-08-29 - Table 2: Dosage Adjustment for Patients with Renal Impairment Creatinine Clearance Dose Frequency 55 mL/min. or greater full dose normal frequency 35 to 54 mL/min. full dose every 8 hours or longer 11 to 34 mL/min. 1/2 usual dose every 12 hours 10 mL/min. Source: This line points to a numbered table that this card does not show - read that table in the label before you dose. US FDA label for cefazolin (Cefazolin), section 'dosage and administration', retrieved 2026-08-29 - Pediatric Dosage Guide Weight 25 mg/kg/Day Divided into 3 Doses 25 mg/kg/Day Divided into 4 Doses Lbs Kg Approximate Single Dose mg/q8h Vol. Source: US FDA label for cefazolin (Cefazolin), section 'dosage and administration', retrieved 2026-08-29 RENAL IMPAIRMENT - ( 2 ) Recommended Dosing Schedule in Adult Patients with CrCl Greater Than or Equal to 55 mL/min. Source: US FDA label for cefazolin (Cefazolin), section 'dosage and administration', retrieved 2026-08-29 - Table 1: Recommended Dosing Schedule in Adult Patients with CrCl Greater Than or Equal to 55 mL/min. Source: This line points to a numbered table that this card does not show - read that table in the label before you dose. US FDA label for cefazolin (Cefazolin), section 'dosage and administration', retrieved 2026-08-29 - In surgery where the occurrence of infection may be particularly devastating (e.g., open-heart surgery and prosthetic arthroplasty), the prophylactic administration of cefazolin may be continued for 3 to 5 days following the completion of surgery. 2.3 Patients with Renal Impairment Cefazolin for Injection may be used in patients with reduced renal function with the following dosage adjustments outlined in Table 2 . Source: This line points to a numbered table that this card does not show - read that table in the label before you dose. US FDA label for cefazolin (Cefazolin), section 'dosage and administration', retrieved 2026-08-29 HEPATIC IMPAIRMENT - No liver-impairment dose in this label. Not a statement that none is needed. Source: Read and found silent: the US FDA label for cefazolin (Cefazolin), retrieved 2026-08-29 PREGNANCY [ CAUTION ] The label allows it only when the benefit is judged to outweigh the risk. Read the quote below. - Pregnancy Category B Reproduction studies have been performed in rats, mice and rabbits at doses up to 25 times the human dose and have revealed no evidence of impaired fertility or harm to the fetus due to cefazolin. Source: US FDA label for cefazolin (Cefazolin), section 'pregnancy', retrieved 2026-08-29 - There are, however, no adequate and well-controlled studies in pregnant women. Source: US FDA label for cefazolin (Cefazolin), section 'pregnancy', retrieved 2026-08-29 - Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed. Source: US FDA label for cefazolin (Cefazolin), section 'pregnancy', retrieved 2026-08-29 BREASTFEEDING [ CAUTION ] The label allows it only when the benefit is judged to outweigh the risk. Read the quote below. - Cefazolin for Injection is present in very low concentrations in the milk of nursing mothers. Source: US FDA label for cefazolin (Cefazolin), section 'nursing mothers', retrieved 2026-08-29 - Caution should be exercised when Cefazolin for Injection is administered to a nursing woman. Source: US FDA label for cefazolin (Cefazolin), section 'nursing mothers', retrieved 2026-08-29 - The drug appears to have no adverse effect on the fetus. 8.3 Nursing Mothers Cefazolin for Injection is present in very low concentrations in the milk of nursing mothers. Source: US FDA label for cefazolin (Cefazolin), section 'use in specific populations', retrieved 2026-08-29 ``` --- Dawaa Reference is a reference for prescribers, not a medical device, and does not replace clinical judgement. 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