{
  "schema_version": 1,
  "kind": "drug_profile",
  "generic": "captopril",
  "review_status": "reviewed",
  "origin": "openfda",
  "sections": {
    "adult": [
      {
        "text": "The initial dose of captopril tablets, USP is 25 mg b.i.d. or t.i.d.",
        "source": "US FDA label for captopril (Captopril), section 'dosage and administration', retrieved 2026-08-29",
        "cached_file": "labels/captopril.json",
        "verbatim": true
      },
      {
        "text": "If satisfactory reduction of blood pressure has not been achieved after one or two weeks, the dose may be increased to 50 mg b.i.d. or t.i.d.",
        "source": "US FDA label for captopril (Captopril), section 'dosage and administration', retrieved 2026-08-29",
        "cached_file": "labels/captopril.json",
        "verbatim": true
      },
      {
        "text": "The dose of captopril in hypertension usually does not exceed 50 mg t.i.d.",
        "source": "US FDA label for captopril (Captopril), section 'dosage and administration', retrieved 2026-08-29",
        "cached_file": "labels/captopril.json",
        "verbatim": true
      }
    ],
    "child": [
      {
        "text": "Neonates with a history of in utero exposure to captopril: If oliguria or hypotension occurs, direct attention toward support of blood pressure and renal perfusion. Exchange transfusions or dialysis may be required as a means of reversing hypotension and/or substituting for disordered renal function.",
        "source": "US FDA label for captopril (Captopril), section 'pediatric use', retrieved 2026-08-29",
        "cached_file": "labels/captopril.json",
        "verbatim": true
      }
    ],
    "renal": [
      {
        "text": "Dosage Adjustment in Renal Impairment: Because captopril is excreted primarily by the kidneys, excretion rates are reduced in patients with impaired renal function.",
        "source": "US FDA label for captopril (Captopril), section 'dosage and administration', retrieved 2026-08-29",
        "cached_file": "labels/captopril.json",
        "verbatim": true
      },
      {
        "text": "Accordingly, for patients with significant renal impairment, initial daily dosage of captopril should be reduced, and smaller increments utilized for titration, which should be quite slow (one-to two-week intervals).",
        "source": "US FDA label for captopril (Captopril), section 'dosage and administration', retrieved 2026-08-29",
        "cached_file": "labels/captopril.json",
        "verbatim": true
      },
      {
        "text": "When concomitant diuretic therapy is required, a loop diuretic (e.g., furosemide), rather than a thiazide diuretic, is preferred in patients with severe renal impairment (see WARNINGS: Anaphylactoid reactions during membrane exposure and PRECAUTIONS: Hemodialysis ).",
        "source": "US FDA label for captopril (Captopril), section 'dosage and administration', retrieved 2026-08-29",
        "cached_file": "labels/captopril.json",
        "verbatim": true
      }
    ],
    "hepatic": [
      {
        "text": "No liver-impairment dose in this label. Not a statement that none is needed.",
        "source": "Read and found silent: the US FDA label for captopril (Captopril), retrieved 2026-08-29",
        "cached_file": "labels/captopril.json",
        "verbatim": false
      }
    ],
    "pregnancy": [
      {
        "text": "Female patients of childbearing age should be told about the consequences of exposure to captopril during pregnancy.",
        "source": "US FDA label for captopril (Captopril), section 'pregnancy', retrieved 2026-08-29",
        "cached_file": "labels/captopril.json",
        "verbatim": true
      },
      {
        "text": "Discuss treatment options with women planning to become pregnant.",
        "source": "US FDA label for captopril (Captopril), section 'pregnancy', retrieved 2026-08-29",
        "cached_file": "labels/captopril.json",
        "verbatim": true
      },
      {
        "text": "Patients should be asked to report pregnancies to their physicians as soon as possible.",
        "source": "US FDA label for captopril (Captopril), section 'pregnancy', retrieved 2026-08-29",
        "cached_file": "labels/captopril.json",
        "verbatim": true
      }
    ],
    "lactation": [
      {
        "text": "Concentrations of captopril in human milk are approximately one percent of those in maternal blood.",
        "source": "US FDA label for captopril (Captopril), section 'nursing mothers', retrieved 2026-08-29",
        "cached_file": "labels/captopril.json",
        "verbatim": true
      },
      {
        "text": "Because of the potential for serious adverse reactions in nursing infants from captopril, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of captopril to the mother (see PRECAUTIONS: Pediatric Use ).",
        "source": "US FDA label for captopril (Captopril), section 'nursing mothers', retrieved 2026-08-29",
        "cached_file": "labels/captopril.json",
        "verbatim": true
      }
    ]
  }
}