Captopril

DRUG INFORMATION

  ADULT
    - The initial dose of captopril tablets, USP is 25 mg b.i.d. or t.i.d.
      Source: US FDA label for captopril (Captopril), section 'dosage and
      administration', retrieved 2026-08-29
    - If satisfactory reduction of blood pressure has not been achieved after one or two
      weeks, the dose may be increased to 50 mg b.i.d. or t.i.d.
      Source: US FDA label for captopril (Captopril), section 'dosage and
      administration', retrieved 2026-08-29
    - The dose of captopril in hypertension usually does not exceed 50 mg t.i.d.
      Source: US FDA label for captopril (Captopril), section 'dosage and
      administration', retrieved 2026-08-29

  CHILD
    - Neonates with a history of in utero exposure to captopril: If oliguria or
      hypotension occurs, direct attention toward support of blood pressure and renal
      perfusion. Exchange transfusions or dialysis may be required as a means of
      reversing hypotension and/or substituting for disordered renal function.
      Source: US FDA label for captopril (Captopril), section 'pediatric use', retrieved
      2026-08-29

  RENAL IMPAIRMENT
    - Dosage Adjustment in Renal Impairment: Because captopril is excreted primarily by
      the kidneys, excretion rates are reduced in patients with impaired renal function.
      Source: US FDA label for captopril (Captopril), section 'dosage and
      administration', retrieved 2026-08-29
    - Accordingly, for patients with significant renal impairment, initial daily dosage
      of captopril should be reduced, and smaller increments utilized for titration,
      which should be quite slow (one-to two-week intervals).
      Source: US FDA label for captopril (Captopril), section 'dosage and
      administration', retrieved 2026-08-29
    - When concomitant diuretic therapy is required, a loop diuretic (e.g., furosemide),
      rather than a thiazide diuretic, is preferred in patients with severe renal
      impairment (see WARNINGS: Anaphylactoid reactions during membrane exposure and
      PRECAUTIONS: Hemodialysis ).
      Source: US FDA label for captopril (Captopril), section 'dosage and
      administration', retrieved 2026-08-29

  HEPATIC IMPAIRMENT
    - No liver-impairment dose in this label. Not a statement that none is needed.
      Source: Read and found silent: the US FDA label for captopril (Captopril),
      retrieved 2026-08-29

  PREGNANCY
    - Female patients of childbearing age should be told about the consequences of
      exposure to captopril during pregnancy.
      Source: US FDA label for captopril (Captopril), section 'pregnancy', retrieved
      2026-08-29
    - Discuss treatment options with women planning to become pregnant.
      Source: US FDA label for captopril (Captopril), section 'pregnancy', retrieved
      2026-08-29
    - Patients should be asked to report pregnancies to their physicians as soon as
      possible.
      Source: US FDA label for captopril (Captopril), section 'pregnancy', retrieved
      2026-08-29

  BREASTFEEDING
    - Concentrations of captopril in human milk are approximately one percent of those
      in maternal blood.
      Source: US FDA label for captopril (Captopril), section 'nursing mothers',
      retrieved 2026-08-29
    - Because of the potential for serious adverse reactions in nursing infants from
      captopril, a decision should be made whether to discontinue nursing or to
      discontinue the drug, taking into account the importance of captopril to the
      mother (see PRECAUTIONS: Pediatric Use ).
      Source: US FDA label for captopril (Captopril), section 'nursing mothers',
      retrieved 2026-08-29