Bisoprolol

DRUG INFORMATION

  ADULT
    - The usual starting dose is 5 mg once daily.
      Source: US FDA label for bisoprolol (Bisoprolol fumarate), section 'dosage and
      administration', retrieved 2026-08-29
    - In some patients, 2.5 mg may be an appropriate starting dose (see Bronchospastic
      Disease in WARNINGS ).
      Source: US FDA label for bisoprolol (Bisoprolol fumarate), section 'dosage and
      administration', retrieved 2026-08-29
    - If the antihypertensive effect of 5 mg is inadequate, the dose may be increased to
      10 mg and then, if necessary, to 20 mg once daily.
      Source: US FDA label for bisoprolol (Bisoprolol fumarate), section 'dosage and
      administration', retrieved 2026-08-29

  CHILD
    - Safety and effectiveness in pediatric patients have not been established.
      Source: US FDA label for bisoprolol (Bisoprolol fumarate), section 'pediatric
      use', retrieved 2026-08-29
    - The dose of bisoprolol fumarate tablets must be individualized to the needs of the
      patient. The usual starting dose is 5 mg once daily. In some patients, 2.5 mg may
      be an appropriate starting dose (see Bronchospastic Disease in WARNINGS ). If the
      antihypertensive effect of 5 mg is inadequate, the dose may be increased to 10 mg
      and then, if necessary, to 20 mg once daily.
      Source: US FDA label for bisoprolol (Bisoprolol fumarate), section 'dosage and
      administration', retrieved 2026-08-29

  RENAL IMPAIRMENT
    - Patients with Renal or Hepatic Impairment In patients with hepatic impairment
      (hepatitis or cirrhosis) or renal dysfunction (creatinine clearance less than 40
      mL/min), the initial daily dose should be 2.5 mg and caution should be used in
      dose-titration.
      Source: US FDA label for bisoprolol (Bisoprolol fumarate), section 'dosage and
      administration', retrieved 2026-08-29
    - Since limited data suggest that bisoprolol fumarate is not dialyzable, drug
      replacement is not necessary in patients undergoing dialysis.
      Source: US FDA label for bisoprolol (Bisoprolol fumarate), section 'dosage and
      administration', retrieved 2026-08-29

  HEPATIC IMPAIRMENT
    - Patients with Renal or Hepatic Impairment In patients with hepatic impairment
      (hepatitis or cirrhosis) or renal dysfunction (creatinine clearance less than 40
      mL/min), the initial daily dose should be 2.5 mg and caution should be used in
      dose-titration.
      Source: US FDA label for bisoprolol (Bisoprolol fumarate), section 'dosage and
      administration', retrieved 2026-08-29

  PREGNANCY
    - In rats, bisoprolol fumarate was not teratogenic at doses up to 150 mg/kg/day
      which is 375 and 77 times the MRHD on the basis of body weight and body surface
      area, respectively.
      Source: US FDA label for bisoprolol (Bisoprolol fumarate), section 'pregnancy',
      retrieved 2026-08-29
    - Bisoprolol fumarate was fetotoxic (increased late resorptions) at 50 mg/kg/day and
      maternotoxic (decreased food intake and body weight gain) at 150 mg/kg/day.
      Source: US FDA label for bisoprolol (Bisoprolol fumarate), section 'pregnancy',
      retrieved 2026-08-29
    - The fetotoxicity in rats occurred at 125 times the MRHD on a body weight basis and
      26 times the MRHD on the basis of body surface area.
      Source: US FDA label for bisoprolol (Bisoprolol fumarate), section 'pregnancy',
      retrieved 2026-08-29

  BREASTFEEDING
    - Small amounts of bisoprolol fumarate (< 2% of the dose) have been detected in the
      milk of lactating rats.
      Source: US FDA label for bisoprolol (Bisoprolol fumarate), section 'nursing
      mothers', retrieved 2026-08-29
    - It is not known whether this drug is excreted in human milk.
      Source: US FDA label for bisoprolol (Bisoprolol fumarate), section 'nursing
      mothers', retrieved 2026-08-29
    - Because many drugs are excreted in human milk caution should be exercised when
      bisoprolol fumarate is administered to nursing women.
      Source: US FDA label for bisoprolol (Bisoprolol fumarate), section 'nursing
      mothers', retrieved 2026-08-29