{
  "schema_version": 1,
  "kind": "drug_profile",
  "generic": "allopurinol",
  "review_status": "reviewed",
  "origin": "openfda",
  "sections": {
    "adult": [
      {
        "text": "( 2.1 , 2.2 ) Patients with normal kidney function: Initial dosage is 100 mg orally daily.",
        "source": "US FDA label for allopurinol (Allopurinol), section 'dosage and administration', retrieved 2026-08-29",
        "cached_file": "labels/allopurinol.json",
        "verbatim": true
      },
      {
        "text": "Increase by 100 mg weekly increments until serum uric acid of 6 mg/dl or less is reached (maximum 800 mg daily).",
        "source": "US FDA label for allopurinol (Allopurinol), section 'dosage and administration', retrieved 2026-08-29",
        "cached_file": "labels/allopurinol.json",
        "verbatim": true
      },
      {
        "text": "( 2.3 ) Patients with impaired kidney function: The initial dosage is 50 mg orally daily.",
        "source": "US FDA label for allopurinol (Allopurinol), section 'dosage and administration', retrieved 2026-08-29",
        "cached_file": "labels/allopurinol.json",
        "verbatim": true
      }
    ],
    "child": [
      {
        "text": "Hyperuricemia Associated with Cancer Therapy The safety and effectiveness of allopurinol for the management of pediatric patients with leukemia, lymphoma and solid tumor malignancies who are receiving cancer therapy which causes elevations of serum and urinary uric acid levels have been established in approximately 200 pediatric patients. The efficacy and safety profile observed in this patient population were similar to that observed in adults.",
        "source": "US FDA label for allopurinol (Allopurinol), section 'pediatric use', retrieved 2026-08-29",
        "cached_file": "labels/allopurinol.json",
        "verbatim": true
      },
      {
        "text": "Gout : Prior to initiating treatment assess serum uric acid level, complete blood count, chemistry panel, liver and kidney function tests. Prophylactic treatment for gout flares is recommended. ( 2.1 , 2.2 ) Patients with normal kidney function: Initial dosage is 100 mg orally daily. Increase by 100 mg weekly increments until serum uric acid of 6 mg/dl or less is reached (maximum 800 mg daily).",
        "source": "US FDA label for allopurinol (Allopurinol), section 'dosage and administration', retrieved 2026-08-29",
        "cached_file": "labels/allopurinol.json",
        "verbatim": true
      },
      {
        "text": "Pediatric patients: 100 mg/m 2 orally every 8 hours to 12 hours (10 mg/kg/day, maximum 800 mg/day) See complete information in the FPI.",
        "source": "US FDA label for allopurinol (Allopurinol), section 'dosage and administration', retrieved 2026-08-29",
        "cached_file": "labels/allopurinol.json",
        "verbatim": true
      }
    ],
    "renal": [
      {
        "text": "Follow recommendations for titration in patients with renal impairment until target serum uric acid level is reached.",
        "source": "US FDA label for allopurinol (Allopurinol), section 'dosage and administration', retrieved 2026-08-29",
        "cached_file": "labels/allopurinol.json",
        "verbatim": true
      },
      {
        "text": "( 2.5 ) Dosage in Patients with Renal Impairment: See FPI for dosage modifications in patients with renal impairment.",
        "source": "US FDA label for allopurinol (Allopurinol), section 'dosage and administration', retrieved 2026-08-29",
        "cached_file": "labels/allopurinol.json",
        "verbatim": true
      },
      {
        "text": "( 2.6 ) 2.1 Recommended Testing Prior to Treatment Initiation Prior to initiating treatment with allopurinol tablets in patients with gout, assess the following baseline tests: serum uric acid level, complete blood count, chemistry panel, liver function tests (serum alanine aminotransferase [ALT], aspartate aminotransferase [AST], alkaline phosphatase, and total bilirubin), kidney function tests (serum creatinine and eGFR).",
        "source": "US FDA label for allopurinol (Allopurinol), section 'dosage and administration', retrieved 2026-08-29",
        "cached_file": "labels/allopurinol.json",
        "verbatim": true
      }
    ],
    "hepatic": [
      {
        "text": "In patients with pre-existing liver disease, monitor liver enzymes periodically.",
        "source": "US FDA label for allopurinol (Allopurinol), section 'warnings and cautions', retrieved 2026-08-29",
        "cached_file": "labels/allopurinol.json",
        "verbatim": true
      }
    ],
    "pregnancy": [
      {
        "text": "Risk Summary Based on findings in animals, allopurinol tablets may cause fetal harm when administered to a pregnant woman.",
        "source": "US FDA label for allopurinol (Allopurinol), section 'pregnancy', retrieved 2026-08-29",
        "cached_file": "labels/allopurinol.json",
        "verbatim": true
      },
      {
        "text": "Adverse developmental outcomes have been described in exposed animals (see Data).",
        "source": "US FDA label for allopurinol (Allopurinol), section 'pregnancy', retrieved 2026-08-29",
        "cached_file": "labels/allopurinol.json",
        "verbatim": true
      },
      {
        "text": "Allopurinol and its metabolite oxypurinol have been shown to cross the placenta following administration of maternal allopurinol.",
        "source": "US FDA label for allopurinol (Allopurinol), section 'pregnancy', retrieved 2026-08-29",
        "cached_file": "labels/allopurinol.json",
        "verbatim": true
      }
    ],
    "lactation": [
      {
        "text": "( 8.1 ) Lactation: Advise not to breastfeed.",
        "source": "US FDA label for allopurinol (Allopurinol), section 'use in specific populations', retrieved 2026-08-29",
        "cached_file": "labels/allopurinol.json",
        "verbatim": true
      },
      {
        "text": "It is uncertain whether these findings represented a fetal effect or an effect secondary to maternal toxicity. 8.2 Lactation Risk Summary Allopurinol and oxypurinol are present in human milk.",
        "source": "US FDA label for allopurinol (Allopurinol), section 'use in specific populations', retrieved 2026-08-29",
        "cached_file": "labels/allopurinol.json",
        "verbatim": true
      },
      {
        "text": "There was no report of effects of allopurinol on the breastfed infant or on milk production.",
        "source": "US FDA label for allopurinol (Allopurinol), section 'use in specific populations', retrieved 2026-08-29",
        "cached_file": "labels/allopurinol.json",
        "verbatim": true
      }
    ]
  }
}