{ "schema_version": 1, "kind": "condition", "id": "worm-reinfestation-prevention", "name": "Recurrent Intestinal Worm Reinfestation", "category": "infectious", "sources": "CDC Enterobiasis Guidelines 2020 · Egyptian National Drug Formulary - Antimicrobial 2023 (mebendazole monograph) · MSF Essential Drugs 2024 - albendazole (oral), indications and dosage (msf-essential-drugs-2024.txt, page 27)", "review_status": "reviewed", "verified_against": "Egyptian National Drug Formulary - Antimicrobial 2023 (mebendazole monograph) · MSF Essential Drugs 2024 - albendazole (oral), indications and dosage (msf-essential-drugs-2024.txt, page 27)", "verified_date": "2026-08", "treatments": [ { "id": 1973, "generic": "Mebendazole", "line": 1, "is_adjunct": false, "form": "oral.solid", "strength_mg": 100.0, "adult_dose": "100 mg single dose, REPEAT a second 100 mg dose after 14 days", "adult_duration": "Single dose repeated at 14 days", "dose_source": "Egyptian National Drug Formulary - Antimicrobial 2023 (mebendazole monograph)", "rationale": "Repeat dose at 14 days is essential to kill newly hatched ova and prevent household cycle reinfestation", "cautions": [ "HOUSEHOLD RULE: Treat ALL household members simultaneously regardless of symptoms.", "Repeat 2nd dose strictly 14 days later (first dose kills adult worms, second dose kills newly hatched eggs).", "The Egyptian formulary gives mebendazole for adults, adolescents and children over 2 years. Use below 2 years is outside that range - weigh it deliberately rather than by habit.", "Experience in children <2 years is limited; convulsions have been reported in children <1 year." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "Treatment of patients ≥2 years of age: 100 mg as a single dose; repeat in 2 weeks", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": [ { "label": "2 years and over", "age_min_months": 24, "age_max_months": 216, "dose_text": "100 mg single dose; repeat in 2 weeks" } ], "peds_doses": null, "brands": [ { "trade_name": "MEBAMOX 100MG 6 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EL NASR", "price_egp": 3.25, "pack_count": 6, "unit_price": 0.54, "strength_mg": 100.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "PENTALMIN 100MG 6 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "PHAROPHARMA", "price_egp": 3.5, "pack_count": 6, "unit_price": 0.58, "strength_mg": 100.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "VERMIN 100MG 6 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MEMPHIS", "price_egp": 8.0, "pack_count": 6, "unit_price": 1.33, "strength_mg": 100.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ANTIVER 100MG 20*6 TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ALEXANDRIA", "price_egp": 200.0, "pack_count": 6, "unit_price": 33.33, "strength_mg": 100.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ANTHELMIN 100MG/5ML SUSP. 30ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "PHARCO", "price_egp": 3.5, "pack_count": null, "unit_price": null, "strength_mg": 100.0, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null }, { "trade_name": "PERMAX 100MG/5ML SUSP. 30ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EIPICO", "price_egp": 10.0, "pack_count": null, "unit_price": null, "strength_mg": 100.0, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null } ], "condition_id": "worm-reinfestation-prevention" }, { "id": 1974, "generic": "Albendazole", "line": 2, "is_adjunct": false, "form": "oral.solid", "strength_mg": 400.0, "adult_dose": "400 mg orally as a single dose; a second 400 mg dose may be given after 2-4 weeks", "adult_duration": "Single dose, optionally repeated once at 2-4 weeks", "dose_source": "MSF Essential Drugs 2024 - albendazole (oral), indications and dosage (msf-essential-drugs-2024.txt, page 27)", "rationale": "Alternative to mebendazole for recurrent enterobiasis where the household cycle keeps re-seeding. MSF Essential Drugs lists enterobiasis (Enterobius vermicularis) among albendazole's indications and gives the repeat dose directly: the first dose kills the adult worms, the repeat catches what has hatched since.", "cautions": [ "HOUSEHOLD RULE: Treat ALL household members simultaneously regardless of symptoms.", "The repeat dose is what prevents reinfestation. For enterobiasis, MSF Essential Drugs 2024 allows a second dose 2 to 4 weeks later. That is a different interval from the 14 days used for mebendazole above - each drug keeps its own source's interval.", "Do not give to a child under 6 months (MSF Essential Drugs 2024).", "Avoid during the first trimester of pregnancy. No contra-indication in breast-feeding.", "Not for a patient with ocular cysticercosis. May cause gastrointestinal upset, headache or dizziness; seizures have been reported where neurocysticercosis was present but undiagnosed.", "The Egyptian formulary's albendazole monograph lists only hydatid disease and neurocysticercosis, and its doses are for those - do not read the 15 mg/kg/day figures across. The dose above is MSF's, for enterobiasis." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "Child over 6 months and 10 kg or more: 400 mg as a single dose, as for adults. Child over 6 months but under 10 kg: 200 mg as a single dose. Not below 6 months. Tablets are to be chewed or crushed.", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": 6.0, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [ { "trade_name": "ALBENDAZOLE 400 MG 6 TABS", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "PHARMA CURE PHARMACEUTICALS > PHARMA CURE", "price_egp": 46.0, "pack_count": 6, "unit_price": 7.67, "strength_mg": 400.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ANTIZOLE 100MG/5ML SUSP. 30ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ALEXANDRIA", "price_egp": 19.0, "pack_count": null, "unit_price": null, "strength_mg": 100.0, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null }, { "trade_name": "ALZENTAL 20MG/ML SUSP. 20ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EIPICO", "price_egp": 21.0, "pack_count": null, "unit_price": null, "strength_mg": 20.0, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null } ], "condition_id": "worm-reinfestation-prevention" } ] }