CLOTRIMAZOLE
Formvaginal
Insert 1 applicatorful of 1% clotrimazole vaginal cream at bedtime for 7 nights (or 2% cream for 3 nights), and apply the same cream externally to the vulva twice daily for up to 7 days for the itching and irritation. The external cream is an add-on to the vaginal course, not a treatment on its own. x 7 nights intravaginally (3 nights if using 2% cream); external application up to 7 days
Listed only for girls 12 years and older and adolescents, and only as vaginal cream: 1% at bedtime for 7 nights (some need 14) or 2% for 3 nights, each with the same twice-daily external application for up to 7 days. The monograph carries nothing for prepubertal vulval symptoms.
Egyptian National Drug Formulary - antimicrobial-2023.pdf, Clotrimazole monograph, Indications and Dosing: Adult - vulvovaginal candidiasis (chapter PDF p400, printed p390)
The formulary explicitly lists 'relief of associated external vulvar itching and irritation' as an indication for clotrimazole vaginal cream, and this external-application line is the most specific match for isolated vulval symptoms (as opposed to internal vaginal discharge).
- No tampons, douches, spermicides or intercourse during treatment.
- Avoid with vaginal progesterone — vaginal antifungals may reduce its effect (interaction risk X).
- Reassess if symptoms do not improve within 3 days or last more than 7 days, rather than repeating the course.
- External cream alone will not clear the vaginal infection; give the intravaginal course with it.
- Covers candidal vulvitis only — the label is vaginal yeast infection and the external itching associated with it, not vulval dryness or non-candidal causes.
- A persistent lump, ulcer, or skin change on the vulva needs referral to exclude vulval cancer - not treated with an antifungal.
- If symptoms do not respond to a standard course, re-evaluate for dermatitis, lichen sclerosus, or atrophy rather than repeating antifungal treatment.
- Local irritation or hypersensitivity can occasionally occur with topical azoles.
| Egyptian brand | Manufacturer | Indicative price |
|---|---|---|
| LOCASTEN 2% VAGINAL CREAM 20 GM | ALEXANDRIA | 29.00 EGP |
| CANDISTAN 2% VAGINAL CREAM 20 GM | ARAB DRUG COMPANY (ADCO) | 40.00 EGP |
| CANESTEN 3 2% VAGINAL CREAM 20 GM | MEMPHIS > BAYER HEALTHCARE | 51.00 EGP |
| CANDISTAN 200 MG 3 VAG.TABS. | ARAB DRUG COMPANY (ADCO) | 8.50 EGP |
| CANDISTAN 100 MG 6 VAG.TABS. | ARAB DRUG COMPANY (ADCO) | 9.00 EGP |
| LOCASTEN 1 500 MG 1 VAG. TAB. | ALEXANDRIA | 10.25 EGP |
| KREMA-ROSA 100MG 6 VAG.TABS. | EIPICO | 10.50 EGP |
| LOCASTEN 100 MG 6 VAG. TABS. | ALEXANDRIA | 10.50 EGP |