{ "schema_version": 1, "kind": "condition", "id": "vaginal-candidiasis", "name": "Vaginal candidiasis (vulvovaginal thrush)", "category": "infectious", "sources": "CDC Sexually Transmitted Infections Treatment Guidelines, 2021 (MMWR Recomm Rep 2021;70(4):1-187; PMC8344968), Vulvovaginal Candidiasis - Recommended Regimens, Oral Agent · Egyptian National Drug Formulary - Antimicrobial 2023 (clotrimazole monograph)", "review_status": "reviewed", "verified_against": "CDC Sexually Transmitted Infections Treatment Guidelines, 2021 (MMWR Recomm Rep 2021;70(4):1-187; PMC8344968), Vulvovaginal Candidiasis - Recommended Regimens, Oral Agent · Egyptian National Drug Formulary - Antimicrobial 2023 (clotrimazole monograph) · Vaginal Candidiasis - disease-level clinical article (vaginal-candidiasis-clinical.txt)", "verified_date": "2026-08", "treatments": [ { "id": 1920, "generic": "Fluconazole", "line": 1, "is_adjunct": false, "form": "oral.solid", "strength_mg": 150.0, "adult_dose": "150 mg single oral dose", "adult_duration": "Single dose", "dose_source": "CDC Sexually Transmitted Infections Treatment Guidelines, 2021 (MMWR Recomm Rep 2021;70(4):1-187; PMC8344968), Vulvovaginal Candidiasis - Recommended Regimens, Oral Agent", "rationale": "Convenient single-dose oral treatment of choice for uncomplicated candidiasis", "cautions": [ "CONTRAINDICATED in pregnancy (use topical azole instead).", "Caution with concurrent CYP3A4/CYP2C9 metabolized drugs.", "In severe/recurrent cases, repeat 150 mg dose after 72 hours." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "Not routinely indicated for vaginal candidiasis in pre-pubertal children", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [ { "trade_name": "JENFUNGA 150 MG 1 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EGPI > JENIKO MEDICINE PHARMACEUTICALS", "price_egp": 4.5, "pack_count": 1, "unit_price": 4.5, "strength_mg": 150.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "AMRIFLUCAN 150 MG 2 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "AMRIYA", "price_egp": 11.0, "pack_count": 2, "unit_price": 5.5, "strength_mg": 150.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "FLUDCONRIZOLE 150 MG 1 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "RIVA PHARMA S.A.E.", "price_egp": 6.0, "pack_count": 1, "unit_price": 6.0, "strength_mg": 150.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "FLUCORAL 150 MG 4 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "SEDICO", "price_egp": 60.0, "pack_count": 4, "unit_price": 15.0, "strength_mg": 150.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "TRICONAL 150 MG 1 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "T3A PHARMA > PAXAL", "price_egp": 26.5, "pack_count": 1, "unit_price": 26.5, "strength_mg": 150.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "NAVILUCA 150 MG 2 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "INTERNATIONAL DRUG INDUSTRIES > ROTABIOGEN", "price_egp": 69.0, "pack_count": 2, "unit_price": 34.5, "strength_mg": 150.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "NAZOWELL 150 MG 3 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EGPI > HEALTH WELL", "price_egp": 108.0, "pack_count": 3, "unit_price": 36.0, "strength_mg": 150.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "DIFLUCAN 150 MG 1 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "PFIZER", "price_egp": 111.0, "pack_count": 1, "unit_price": 111.0, "strength_mg": 150.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "DIFLUNAZOLE 25MG/5ML SYRUP 70ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "CID", "price_egp": 28.8, "pack_count": null, "unit_price": null, "strength_mg": 25.0, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null }, { "trade_name": "FLUCAZONIL 25MG/5ML SYRUP 70 ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EL NILE.", "price_egp": 28.8, "pack_count": null, "unit_price": null, "strength_mg": 25.0, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null } ], "condition_id": "vaginal-candidiasis" }, { "id": 1921, "generic": "Clotrimazole", "line": 1, "is_adjunct": false, "form": "vaginal", "strength_mg": 100.0, "adult_dose": "Insert 100 mg vaginal pessary at bedtime for 6 nights (or 500 mg single dose)", "adult_duration": "6 nights (or 1 night for 500 mg)", "dose_source": "Egyptian National Drug Formulary - Antimicrobial 2023 (clotrimazole monograph)", "rationale": "Topical azole preferred in pregnant women", "cautions": [ "MSF Essential Drugs 2024 records no contra-indication in pregnancy, with one proviso: do not use the applicator, which can damage the cervix. Insert with a finger, not the applicator.", "May damage latex condoms and diaphragms.", "Local vaginal burning or irritation may occur." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "Pediatric vulvovaginitis requires specialist evaluation", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [ { "trade_name": "CANDISTAN 100 MG 6 VAG.TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ARAB DRUG COMPANY (ADCO)", "price_egp": 9.0, "pack_count": null, "unit_price": null, "strength_mg": 100.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "KREMA-ROSA 100MG 6 VAG.TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EIPICO", "price_egp": 10.5, "pack_count": null, "unit_price": null, "strength_mg": 100.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "LOCASTEN 100 MG 6 VAG. TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ALEXANDRIA", "price_egp": 10.5, "pack_count": null, "unit_price": null, "strength_mg": 100.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null } ], "condition_id": "vaginal-candidiasis" }, { "id": 1922, "generic": "Referral & safety-netting (no drug therapy)", "line": 1, "is_adjunct": false, "form": null, "strength_mg": null, "adult_dose": null, "adult_duration": null, "dose_source": "Vaginal Candidiasis - disease-level clinical article (vaginal-candidiasis-clinical.txt)", "rationale": "Carries the referral criteria and warning signs for this condition, which apply whichever treatment is chosen.", "cautions": [ "RED FLAG - Persistent symptoms after standard treatment require fungal culture to evaluate for non-albicans Candida species." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": null, "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [], "condition_id": "vaginal-candidiasis" } ] }