TAMSULOSIN
Alpha-blocker
Strength0.4 mg
Formoral.solid
0.4 mg once daily, modified-release capsule; the article allows up to 0.8 mg - Start at the time of catheterisation; it needs 72 hours for full effect, and continues afterwards
Not a paediatric drug. Retention in a child is a different problem with different causes and belongs with a paediatric surgeon or urologist.
Alternatives. All the alpha-blockers work equally well at equivalent doses, so the choice is about side effects and what the pharmacy has: tamsulosin and alfuzosin can be started at the full dose, doxazosin and terazosin have to be titrated and drop the blood pressure more.
Egyptian National Drug Formulary - Cardiovascular (tamsulosin monograph, p20)
THE CATHETER COMES FIRST - the cited article puts immediate bladder decompression with a 16-French Foley ahead of any drug, and says rapid complete drainage is best even for a very large bladder. The drug is what makes the catheter removable. The article names alpha-blockade as the primary first-line medical therapy for retention caused by benign prostatic enlargement, especially over 60, and says a man in acute retention who is not already on one should be started on one, and a man already on one should have the dose maximised. The formulary's tamsulosin monograph names benign prostatic hyperplasia as its indication and gives 0.4 mg daily as the modified-release capsule dose.
- THE DRUG DOES NOT EMPTY THE BLADDER. Catheterise first. If the urethra cannot be passed - and after recent prostatectomy or urethral reconstruction it must not be attempted - a suprapubic tube is needed urgently.
- IT TAKES 72 HOURS to reach full effect, which is why the trial of voiding is not attempted before then.
- The formulary states plainly that tamsulosin is NOT indicated for hypertension. It still drops the blood pressure on standing, particularly with the first dose and in the elderly.
- Warn any man due for cataract surgery, and tell his ophthalmologist: alpha-blockers cause intraoperative floppy iris syndrome, and the surgeon must know before the operation, not after.
- DO NOT GIVE PROPHYLACTIC ANTIBIOTICS with the catheter. The article is explicit that they have been shown not to prevent infection and drive resistance. Treat an infection only if there is one.
- Alfuzosin 10 mg daily and silodosin 4-8 mg daily are the equally effective alternatives in the article. Doxazosin and terazosin work as well but drop the standing blood pressure more and have to be titrated up, so the article does not recommend them for acute retention.
| Egyptian brand | Manufacturer | Indicative price |
|---|---|---|
| NORMIRAMA 0.4 MG 30 CAPS. | EGPI > RAMAPHARMA | 60.00 EGP (2.00/unit) |
| TAMSUNORM S.R. 0.4MG 30 CAPS. | RAMEDA | 60.00 EGP (2.00/unit) |
| TAMSULOSIN 0.4 MG 20 CAPS. | GLAXO SMITHKLINE > SANDOZ | 42.00 EGP (2.10/unit) |
| CUREPRO XR 0.4 MG 30 CAPS. | DEBEIKY > KHUFU PHARMA | 105.00 EGP (3.50/unit) |
| BLOCK ALPHA 0.4 MG MR 30 CAPS. | ADWIA | 120.00 EGP (4.00/unit) |
| FIRAMAZIN 0.4MG 30 H.G.CAPS. | EVA PHARMA | 54.00 EGP |
| OMNIC 0.4MG 30 MODIFIED RELEASE CAPS. | ASTELLAS PHARMA > MULTIPHARMA | 147.00 EGP |
| OMNIC OCAS 0.4 MG 30 PROLONGED RELEASE F.C.TAB. | ASTELLAS PHARMA INC > MULTIPHARMA | 282.00 EGP |