{
  "schema_version": 1,
  "kind": "condition",
  "id": "thrombophilia",
  "name": "Thrombophilia (Clotting Tendency)",
  "category": "chronic",
  "sources": "Hypercoagulability - StatPearls - NCBI Bookshelf - https://www.ncbi.nlm.nih.gov/books/NBK538251/ · ICPC-3 (WONCA International Classification of Primary Care, 3rd edition) class BD78.03 - condition scope only, no dose · No dose - referral pathway, no medicine given in primary care",
  "review_status": "reviewed",
  "verified_against": "No dose - referral pathway, no medicine given in primary care · Thrombophilia (Clotting Tendency) - disease-level clinical article (thrombophilia-clinical.txt)",
  "verified_date": "2026-08",
  "treatments": [
    {
      "id": 1779,
      "generic": "No drug therapy in primary care (Referral & Advice)",
      "line": 1,
      "is_adjunct": false,
      "form": null,
      "strength_mg": null,
      "adult_dose": "Inherited or acquired tendency to abnormal blood clotting. Diagnosis requires specialist coagulation work-up; GP gives urgent advice and initial anticoagulation if a clot is suspected, and may continue long-term anticoagulation once a specialist has set the plan.",
      "adult_duration": "Refer, with advice",
      "dose_source": "No dose - referral pathway, no medicine given in primary care",
      "rationale": "Inherited or acquired tendency to abnormal blood clotting. Diagnosis requires specialist coagulation work-up; GP gives urgent advice and initial anticoagulation if a clot is suspected, and may continue long-term anticoagulation once a specialist has set the plan.",
      "cautions": [
        "No medicine is prescribed for this in primary care - this entry is for recognition and referral. Anything given is decided by the service it is referred to.",
        "RED FLAG - Indefinite anticoagulation is strongly recommended for unprovoked, life-threatening VTE, recurrent VTE, or VTE at unusual locations.",
        "RED FLAG - Homozygous thrombophilia patients undergoing surgery require prophylactic anticoagulation as a high-risk population.",
        "RED FLAG - Unilateral leg swelling or pain (possible DVT), or sudden breathlessness or chest pain (possible PE).",
        "Features that should prompt referral include recurrent pregnancy loss and a clot at a young age or without an obvious trigger."
      ],
      "peds_mgkg_low": null,
      "peds_mgkg_high": null,
      "peds_max_mg": null,
      "peds_basis": null,
      "peds_unit": null,
      "peds_note": "Children follow the same pathway: recognise and refer. No primary-care medicine is implied.",
      "peds_min_weight_kg": null,
      "peds_max_weight_kg": null,
      "peds_age_min_months": null,
      "peds_age_max_months": null,
      "peds_age_bands": null,
      "peds_doses": null,
      "brands": [],
      "condition_id": "thrombophilia"
    }
  ]
}