{ "schema_version": 1, "kind": "condition", "id": "thalassaemia-major-referral", "name": "Thalassaemia Major & Trait Referral", "category": "chronic", "sources": "Thalassaemia International Federation (TIF) Guidelines 2021 · Egyptian National Drug Formulary - Blood Disorder Medications 2025 (folic acid monograph)", "review_status": "reviewed", "verified_against": "Thalassaemia International Federation (TIF) Guidelines 2021 · Egyptian National Drug Formulary - Blood Disorder Medications 2025 (folic acid monograph)", "verified_date": "2026-08", "treatments": [ { "id": 1775, "generic": "Deferasirox", "line": 1, "is_adjunct": false, "form": "oral.solid", "strength_mg": 360.0, "adult_dose": "14 mg/kg once daily (film-coated tablet) or 20 mg/kg once daily (dispersible tablet)", "adult_duration": "long-term under haematology oversight", "dose_source": "Thalassaemia International Federation (TIF) Guidelines 2021", "rationale": "First-line oral iron chelator registered in Egypt for transfusional iron overload", "cautions": [ "IRON OVERLOAD ALERT: Deferasirox is prescribed strictly for transfusional thalassaemia major under specialist care.", "NEVER GIVE IRON SUPPLEMENTS: Iron overload causes fatal cardiac, hepatic, and endocrine toxicity.", "Monitor renal function (creatinine) and serum ferritin monthly.", "Thalassaemia trait (minor) requires reassurance and genetic counseling, NOT iron therapy unless co-existing iron deficiency proven." ], "peds_mgkg_low": 14.0, "peds_mgkg_high": 28.0, "peds_max_mg": 1400.0, "peds_basis": "day", "peds_unit": "mg", "peds_note": "Children >=2 years under pediatric haematologist: film-coated 14 mg/kg once daily, increased if needed to 28 mg/kg/day; dispersible 20 mg/kg once daily. The weight figures above are the film-coated range.", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": [ { "weight_kg": 10, "low_mg": 140, "high_mg": 280, "capped": false }, { "weight_kg": 20, "low_mg": 280, "high_mg": 560, "capped": false }, { "weight_kg": 30, "low_mg": 420, "high_mg": 840, "capped": false }, { "weight_kg": 40, "low_mg": 560, "high_mg": 1120, "capped": false } ], "brands": [ { "trade_name": "DEFEROXINOVA 125MG 10 DISP. TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "DEBEIKY > INNOVA PHARMA", "price_egp": 208.75, "pack_count": null, "unit_price": null, "strength_mg": 125.0, "exact_strength": false, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "DEFEROXINOVA 250MG 10 DISP. TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "DEBEIKY > INNOVA PHARMA", "price_egp": 392.5, "pack_count": null, "unit_price": null, "strength_mg": 250.0, "exact_strength": false, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "RASIROXPINE 125MG 28 DISP. TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "HIKMA SPECIALIZED PHARMACEUTICALS", "price_egp": 750.0, "pack_count": null, "unit_price": null, "strength_mg": 125.0, "exact_strength": false, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "RONISIROX 500MG 10 DISPERSIBLE TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "AVERROES PHARMA-EGYPT", "price_egp": 825.0, "pack_count": null, "unit_price": null, "strength_mg": 500.0, "exact_strength": false, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "RASIROXPINE 250MG 28 DISP. TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "HIKMA SPECIALIZED PHARMACEUTICALS", "price_egp": 1099.0, "pack_count": null, "unit_price": null, "strength_mg": 250.0, "exact_strength": false, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "EXJADE 125MG 28 DISP. TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "NOVARTIS", "price_egp": 1350.0, "pack_count": null, "unit_price": null, "strength_mg": 125.0, "exact_strength": false, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "EXJADE 250MG 28 DISP. TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "NOVARTIS", "price_egp": 2550.0, "pack_count": null, "unit_price": null, "strength_mg": 250.0, "exact_strength": false, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "EXJADE 500MG 28 DISP. TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "NOVARTIS", "price_egp": 4950.0, "pack_count": null, "unit_price": null, "strength_mg": 500.0, "exact_strength": false, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ANDORASIROX 500MG 20TABS. FOR ORAL SUSP.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ANDALOUS PHARMA", "price_egp": 1530.0, "pack_count": 20, "unit_price": 76.5, "strength_mg": 500.0, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null } ], "condition_id": "thalassaemia-major-referral" }, { "id": 1776, "generic": "Folic acid", "line": 1, "is_adjunct": true, "form": "oral.solid", "strength_mg": 5.0, "adult_dose": "5 mg once daily", "adult_duration": "long-term", "dose_source": "Egyptian National Drug Formulary - Blood Disorder Medications 2025 (folic acid monograph)", "rationale": "Adjunct vitamin supplement added to the referral pathway for thalassaemia major to meet the increased folate demand from chronic ineffective erythropoiesis; supports red cell production but does not replace transfusion therapy or specialist management.", "cautions": [ "Supports ineffective erythropoiesis.", "Do not combine with iron supplements." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "Children: 2.5-5 mg once daily", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [ { "trade_name": "FOLIC ACID (EL NILE) 5 MG 50 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EL NILE.", "price_egp": 26.25, "pack_count": 50, "unit_price": 0.53, "strength_mg": 5.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "FOLIC ACID (MEMPHIS) 5 MG 30 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MEMPHIS", "price_egp": 15.75, "pack_count": 30, "unit_price": 0.53, "strength_mg": 5.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "FOLICINAD 5 MG 50 TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "INAD PHARMA", "price_egp": 50.0, "pack_count": 50, "unit_price": 1.0, "strength_mg": 5.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "FOLIC ACID (EIPICO) 5 MG 20 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EIPICO", "price_egp": 24.0, "pack_count": 20, "unit_price": 1.2, "strength_mg": 5.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "FOLIC ACID (EL NILE) 5 MG 30 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EL NILE.", "price_egp": 36.0, "pack_count": 30, "unit_price": 1.2, "strength_mg": 5.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "FOLIRAQ 5000 MCG 30 CAPSULES", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "HP PHARMA", "price_egp": 45.0, "pack_count": 30, "unit_price": 1.5, "strength_mg": 5.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "FOLIDDOX 400 MCG / 5 ML LIQUID 150 ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MADDOX PHARMA", "price_egp": 150.0, "pack_count": null, "unit_price": null, "strength_mg": 0.4, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null } ], "condition_id": "thalassaemia-major-referral" } ] }