{ "schema_version": 1, "kind": "condition", "id": "strongyloidiasis", "name": "Strongyloidiasis", "category": "acute", "sources": "Egyptian National Drug Formulary - antimicrobial-2023.pdf, Ivermectin monograph (chapter PDF p31) · MSF Essential Drugs 2024 (albendazole oral monograph, indication \"Trichuriasis (Trichuris trichiura), strongyloidiasis (Strongyloides stercoralis)\") · Strongyloidiasis - disease-level clinical article (strongyloidiasis-full.txt)", "review_status": "reviewed", "verified_against": "Egyptian National Drug Formulary - antimicrobial-2023.pdf, Ivermectin monograph (chapter PDF p31) · Strongyloidiasis - disease-level clinical article (strongyloidiasis-clinical.txt) · MSF Essential Drugs 2024 (albendazole oral monograph, indication \"Trichuriasis (Trichuris trichiura), strongyloidiasis (Strongyloides stercoralis)\") · Strongyloidiasis - disease-level clinical article (strongyloidiasis-full.txt)", "verified_date": "2026-08", "treatments": [ { "id": 1734, "generic": "Ivermectin", "line": 1, "is_adjunct": false, "form": "oral.solid", "strength_mg": null, "adult_dose": "200 mcg/kg/day", "adult_duration": "1 to 2 days", "dose_source": "Egyptian National Drug Formulary - antimicrobial-2023.pdf, Ivermectin monograph (chapter PDF p31)", "rationale": "Formulary explicitly names intestinal strongyloidiasis with a specific weight-based dose - the guideline-backed first choice.", "cautions": [ "Take on an empty stomach with water for best absorption.", "Screen for and treat before starting any steroid or immunosuppressive therapy - unrecognised strongyloidiasis can progress to life-threatening hyperinfection syndrome once the patient is immunosuppressed.", "Avoid in pregnancy unless the benefit clearly outweighs the risk.", "Investigate unexplained eosinophilia and signs of hyperinfection in an immunocompromised patient as potentially urgent." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "Same weight-based dose (200 mcg/kg/day for 1-2 days) applies from adolescents down to children weighing 15 kg or more; not established below 15 kg in this excerpt.", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [ { "trade_name": "IVACTIN 6MG 6 F.C.TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "DELTA PHARMA", "price_egp": 13.5, "pack_count": 6, "unit_price": 2.25, "strength_mg": 6.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "IVERZINE 6MG 24 TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "UNIPHARMA CO. > UNIPHARMA", "price_egp": 84.0, "pack_count": 24, "unit_price": 3.5, "strength_mg": 6.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null } ], "condition_id": "strongyloidiasis" }, { "id": 1735, "generic": "Referral & safety-netting (no drug therapy)", "line": 1, "is_adjunct": false, "form": null, "strength_mg": null, "adult_dose": null, "adult_duration": null, "dose_source": "Strongyloidiasis - disease-level clinical article (strongyloidiasis-clinical.txt)", "rationale": "Carries the referral criteria and warning signs for this condition, which apply whichever treatment is chosen.", "cautions": [ "RED FLAG - Hyperinfection/disseminated strongyloidiasis is a distinct, very-high-mortality presentation needing a different treatment pathway; immunosuppressed patients, and those about to start immunosuppression, are at particular risk." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": null, "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [], "condition_id": "strongyloidiasis" }, { "id": 1736, "generic": "Albendazole", "line": 2, "is_adjunct": false, "form": "oral.solid", "strength_mg": 400.0, "adult_dose": "400 mg once daily", "adult_duration": "3 days", "dose_source": "MSF Essential Drugs 2024 (albendazole oral monograph, indication \"Trichuriasis (Trichuris trichiura), strongyloidiasis (Strongyloides stercoralis)\")", "rationale": "The card carried ivermectin alone. The disease article names albendazole as the second-line agent, and MSF names strongyloidiasis in albendazole's own indications with a dose attached to that indication. The dose here is MSF's (400 mg once daily for 3 days), NOT the article's 400 mg twice daily for 3-7 days - the dosing document decides the dose. MSF's own remark that ivermectin is more effective is on the row, so the second-line status is visible rather than implied by the ordering.", "cautions": [ "Do not administer to children under 6 months.", "In the treatment of strongyloidiasis, ivermectin is more effective than albendazole.", "May cause: gastrointestinal disturbances, headache, dizziness;", "Tablets are to be chewed or crushed: follow manufacturer's recommendations.", "In pregnancy, avoid albendazole during the first trimester." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "MSF states age and weight bands rather than mg/kg for this indication: child over 6 months, 400 mg once daily for 3 days; child over 6 months but under 10 kg, 200 mg once daily for 3 days. Not to be given under 6 months.", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": [ { "label": "Over 6 months", "age_min_months": 6, "age_max_months": 216, "dose_text": "400 mg once daily for 3 days; under 10 kg, 200 mg once daily for 3 days. Not to be given under 6 months." } ], "peds_doses": null, "brands": [ { "trade_name": "ALBENDAZOLE 400 MG 6 TABS", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "PHARMA CURE PHARMACEUTICALS > PHARMA CURE", "price_egp": 46.0, "pack_count": 6, "unit_price": 7.67, "strength_mg": 400.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ANTIZOLE 100MG/5ML SUSP. 30ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ALEXANDRIA", "price_egp": 19.0, "pack_count": null, "unit_price": null, "strength_mg": 100.0, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null }, { "trade_name": "ALZENTAL 20MG/ML SUSP. 20ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EIPICO", "price_egp": 21.0, "pack_count": null, "unit_price": null, "strength_mg": 20.0, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null } ], "condition_id": "strongyloidiasis" } ] }