{ "schema_version": 1, "kind": "condition", "id": "sepsis-suspected", "name": "Suspected Sepsis (Emergency Referral)", "category": "infectious", "sources": "Surviving Sepsis Campaign Guidelines 2021 · NICE Guideline NG51: Sepsis 2016 (updated 2024) · Septic Shock - StatPearls (NCBI Bookshelf NBK430939) - https://www.ncbi.nlm.nih.gov/books/NBK430939/: \"early identification remains the best therapeutic tool for sepsis treatment and management.\" and \"Broad-spectrum antibiotics within one hour of diagnosis for all patients.\" - which is hospital care, not a primary-care prescription. · Egyptian National Drug Formulary - Antimicrobial 2023", "review_status": "reviewed", "verified_against": "Septic Shock - StatPearls (NCBI Bookshelf NBK430939) - https://www.ncbi.nlm.nih.gov/books/NBK430939/: \"early identification remains the best therapeutic tool for sepsis treatment and management.\" and \"Broad-spectrum antibiotics within one hour of diagnosis for all patients.\" - which is hospital care, not a primary-care prescription. · Egyptian National Drug Formulary - Antimicrobial 2023", "verified_date": "2026-08", "treatments": [ { "id": 1670, "generic": "No drug therapy in primary care (Emergency Referral)", "line": 1, "is_adjunct": false, "form": null, "strength_mg": null, "adult_dose": null, "adult_duration": null, "dose_source": "Septic Shock - StatPearls (NCBI Bookshelf NBK430939) - https://www.ncbi.nlm.nih.gov/books/NBK430939/: \"early identification remains the best therapeutic tool for sepsis treatment and management.\" and \"Broad-spectrum antibiotics within one hour of diagnosis for all patients.\" - which is hospital care, not a primary-care prescription.", "rationale": "Sepsis is a medical emergency requiring rapid hospital transfer for diagnostic blood cultures, IV fluid resuscitation, and broad-spectrum IV antimicrobials within the first hour.", "cautions": [ "TIME-CRITICAL EMERGENCY: Red flag signs include altered mental status, systolic BP <90 mmHg, respiratory rate >=22/min, non-blanching rash, or anuria.", "Do not delay hospital transport for primary care procedures; communicate suspected sepsis to receiving emergency department." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": null, "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [], "condition_id": "sepsis-suspected" }, { "id": 1671, "generic": "Ceftriaxone", "line": 1, "is_adjunct": true, "form": "injection", "strength_mg": 1000.0, "adult_dose": "IV or IM 1–2 g once or devided twice daily.", "adult_duration": null, "dose_source": "Egyptian National Drug Formulary - Antimicrobial 2023", "rationale": "NICE NG51 permits pre-hospital broad-spectrum IV/IM antibiotic administration when hospital transfer is delayed by over 1 hour.", "cautions": [ "Only administer pre-hospital antibiotics if it does not delay immediate emergency transfer.", "Contraindicated in patients with severe cephalosporin or penicillin anaphylaxis.", "The formulary's paediatric figure for a severe infection is 100 mg/kg/day, maximum 4 g, and 50 mg/kg every 24 hours in a neonate." ], "peds_mgkg_low": 80.0, "peds_mgkg_high": 80.0, "peds_max_mg": 2000.0, "peds_basis": "dose", "peds_unit": "mg", "peds_note": "Severe infection (eg, meningitis, penicillin-resistant pneumococcal pneumonia): 100 mg/kg/day divided every 12 to 24 hours; maximum daily dose: 4,000 mg/day", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": [ { "weight_kg": 10, "low_mg": 800, "high_mg": 800, "capped": false }, { "weight_kg": 20, "low_mg": 1600, "high_mg": 1600, "capped": false }, { "weight_kg": 30, "low_mg": 2000, "high_mg": 2000, "capped": true }, { "weight_kg": 40, "low_mg": 2000, "high_mg": 2000, "capped": true } ], "brands": [ { "trade_name": "ZOXIDEL 1 GM PD. FOR I.M. INJ.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "RAMEDA > DELTA PHARMA", "price_egp": 22.0, "pack_count": null, "unit_price": null, "strength_mg": 1000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "CEFTRIAXONE SODIUM 1 GM I.M.VIAL (KAHIRA)", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "KAHIRA", "price_egp": 29.0, "pack_count": null, "unit_price": null, "strength_mg": 1000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ZOXIDEL 1 GM PD. FOR I.V. INJ.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "RAMEDA > DELTA PHARMA", "price_egp": 29.0, "pack_count": null, "unit_price": null, "strength_mg": 1000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "WINTRIAXONE 1 GM PD. FOR I.V INJ.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "SANOFI", "price_egp": 48.0, "pack_count": null, "unit_price": null, "strength_mg": 1000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "VOTRIAXONE 1 GM I.M VIAL", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "CHEMIPHARM", "price_egp": 56.0, "pack_count": null, "unit_price": null, "strength_mg": 1000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "OFRAMAX 1 GM I.M. VIAL", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "RAMEDA > SUN PHARMA EGYPT LIMITED", "price_egp": 71.0, "pack_count": null, "unit_price": null, "strength_mg": 1000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "TRIAXONE 1 GM I.M. VIAL", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "TABUK PHARMACEUTICAL MANUFACTURING COMPANY > TABUK PHARMA", "price_egp": 106.0, "pack_count": null, "unit_price": null, "strength_mg": 1000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "TRIAXONE 1 GM I.V VIAL", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "TABUK PHARMACEUTICAL MANUFACTURING COMPANY > TABUK PHARMA", "price_egp": 106.0, "pack_count": null, "unit_price": null, "strength_mg": 1000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null } ], "condition_id": "sepsis-suspected" } ] }