{
  "schema_version": 1,
  "kind": "condition",
  "id": "schistosomiasis",
  "name": "Schistosomiasis",
  "category": "infectious",
  "sources": "Egyptian MOH Schistosomiasis Protocol 2020 for the national regimen, with the dose from Egyptian National Drug Formulary - Antimicrobial 2023, praziquantel monograph (endf-antimicrobial-2023.txt): \"S. haematobium, Schistosoma intercalatum, or S. mansoni: Oral: 40 mg/kg/day as a single dose or in 2 divided doses for 1 day\" and \"S. japonicum or S. mekongi: Oral: 60 mg/kg/day in 2 -3 divided doses for 1 day\". The formulary states no absolute milligram ceiling; the 3600 mg cap here is 60 mg/kg at 60 kg. · Egyptian MOH Schistosomiasis Protocol 2020 · CDC Yellow Book 2024 · WHO Schistosomiasis 2022",
  "review_status": "reviewed",
  "verified_against": "Egyptian MOH Schistosomiasis Protocol 2020 for the national regimen, with the dose from Egyptian National Drug Formulary - Antimicrobial 2023, praziquantel monograph (endf-antimicrobial-2023.txt): \"S. haematobium, Schistosoma intercalatum, or S. mansoni: Oral: 40 mg/kg/day as a single dose or in 2 divided doses for 1 day\" and \"S. japonicum or S. mekongi: Oral: 60 mg/kg/day in 2 -3 divided doses for 1 day\". The formulary states no absolute milligram ceiling; the 3600 mg cap here is 60 mg/kg at 60 kg. · Egyptian MOH Schistosomiasis Protocol 2020",
  "verified_date": "2026-08",
  "treatments": [
    {
      "id": 1640,
      "generic": "Praziquantel",
      "line": 1,
      "is_adjunct": false,
      "form": "oral.solid",
      "strength_mg": 600.0,
      "adult_dose": "40 mg/kg single dose (or 60 mg/kg divided in 2 doses 4h apart)",
      "adult_duration": "single-dose",
      "dose_source": "Egyptian MOH Schistosomiasis Protocol 2020 for the national regimen, with the dose from Egyptian National Drug Formulary - Antimicrobial 2023, praziquantel monograph (endf-antimicrobial-2023.txt): \"S. haematobium, Schistosoma intercalatum, or S. mansoni: Oral: 40 mg/kg/day as a single dose or in 2 divided doses for 1 day\" and \"S. japonicum or S. mekongi: Oral: 60 mg/kg/day in 2 -3 divided doses for 1 day\". The formulary states no absolute milligram ceiling; the 3600 mg cap here is 60 mg/kg at 60 kg.",
      "rationale": "Praziquantel is the sole listed treatment because it is the only drug in routine use; oxamniquine was withdrawn globally.",
      "cautions": [
        "Egyptian MOH: 40 mg/kg for S. haematobium, 60 mg/kg for S. mansoni",
        "Abdominal pain may occur due to dead worm expulsion.",
        "This is a bitter tablet - take it with liquid during a meal without chewing.",
        "Dizziness and headache are common; do not drive for 24 hours."
      ],
      "peds_mgkg_low": 40.0,
      "peds_mgkg_high": 60.0,
      "peds_max_mg": 3600.0,
      "peds_basis": "day",
      "peds_unit": "mg",
      "peds_note": "Single dose or divided into 2 doses 4 hours apart; take after a meal",
      "peds_min_weight_kg": null,
      "peds_max_weight_kg": null,
      "peds_age_min_months": null,
      "peds_age_max_months": null,
      "peds_age_bands": null,
      "peds_doses": [
        {
          "weight_kg": 10,
          "low_mg": 400,
          "high_mg": 600,
          "capped": false
        },
        {
          "weight_kg": 20,
          "low_mg": 800,
          "high_mg": 1200,
          "capped": false
        },
        {
          "weight_kg": 30,
          "low_mg": 1200,
          "high_mg": 1800,
          "capped": false
        },
        {
          "weight_kg": 40,
          "low_mg": 1600,
          "high_mg": 2400,
          "capped": false
        }
      ],
      "brands": [
        {
          "trade_name": "PRAZIQUANTEL 600MG 4 F.C. TAB.",
          "scientific_name": null,
          "normalized_ingredient": null,
          "manufacturer": "UP PHARMA",
          "price_egp": 6.25,
          "pack_count": 4,
          "unit_price": 1.56,
          "strength_mg": 600.0,
          "exact_strength": true,
          "exact_form": true,
          "discontinued": false,
          "also_contains": null
        },
        {
          "trade_name": "PRAZIQUANTEL 600MG 4 F.C.TAB.",
          "scientific_name": null,
          "normalized_ingredient": null,
          "manufacturer": "SEDICO",
          "price_egp": 6.5,
          "pack_count": 4,
          "unit_price": 1.62,
          "strength_mg": 600.0,
          "exact_strength": true,
          "exact_form": true,
          "discontinued": false,
          "also_contains": null
        },
        {
          "trade_name": "EPIQUANTEL 600MG 4 F.C. TABS.",
          "scientific_name": null,
          "normalized_ingredient": null,
          "manufacturer": "EIPICO",
          "price_egp": 32.0,
          "pack_count": 4,
          "unit_price": 8.0,
          "strength_mg": 600.0,
          "exact_strength": true,
          "exact_form": true,
          "discontinued": false,
          "also_contains": null
        },
        {
          "trade_name": "BILTRICIDE 600 MG 4 F.C.TABS.",
          "scientific_name": null,
          "normalized_ingredient": null,
          "manufacturer": "ALEXANDRIA",
          "price_egp": 33.0,
          "pack_count": 4,
          "unit_price": 8.25,
          "strength_mg": 600.0,
          "exact_strength": true,
          "exact_form": true,
          "discontinued": false,
          "also_contains": null
        },
        {
          "trade_name": "SCHISTOCIDE 600MG/5ML SUSP. 15ML",
          "scientific_name": null,
          "normalized_ingredient": null,
          "manufacturer": "DELTA PHARMA",
          "price_egp": 7.0,
          "pack_count": null,
          "unit_price": null,
          "strength_mg": 600.0,
          "exact_strength": false,
          "exact_form": false,
          "discontinued": false,
          "also_contains": null
        }
      ],
      "condition_id": "schistosomiasis"
    }
  ]
}