{ "schema_version": 1, "kind": "condition", "id": "scarlet-fever", "name": "Scarlet Fever", "category": "infectious", "sources": "NICE Guideline: Scarlet fever 2022 · Egyptian National Drug Formulary - Antimicrobial 2023 (azithromycin monograph) · Egyptian National Drug Formulary, antimicrobial 2023, amoxicillin monograph, paediatric dosing · Egyptian National Drug Formulary, antimicrobial 2023, azithromycin monograph, paediatric dosing · Scarlet Fever - disease-level clinical article (scarlet-fever-full.txt) · Egyptian National Drug Formulary - Antimicrobial 2023 (phenoxymethylpenicillin monograph) · Egyptian National Drug Formulary - Antimicrobial 2023 (clindamycin monograph) · Egyptian National Drug Formulary - Antimicrobial 2023 (penicillin G benzathine monograph, group A streptococcal pharyngitis)", "review_status": "reviewed", "verified_against": "Egyptian National Drug Formulary, antimicrobial 2023, amoxicillin monograph, paediatric dosing · Egyptian National Drug Formulary, antimicrobial 2023, azithromycin monograph, paediatric dosing · Scarlet Fever - disease-level clinical article (scarlet-fever-full.txt) · Egyptian National Drug Formulary - Antimicrobial 2023 (phenoxymethylpenicillin monograph) · Egyptian National Drug Formulary - Antimicrobial 2023 (clindamycin monograph) · Egyptian National Drug Formulary - Antimicrobial 2023 (penicillin G benzathine monograph, group A streptococcal pharyngitis)", "verified_date": "2026-08", "treatments": [ { "id": 1634, "generic": "Amoxicillin", "line": 1, "is_adjunct": false, "form": "oral.solid", "strength_mg": 500.0, "adult_dose": "500 mg twice daily or 1 g once daily", "adult_duration": "10 days", "dose_source": "Egyptian National Drug Formulary, antimicrobial 2023, amoxicillin monograph, paediatric dosing", "rationale": "Amoxicillin is preferred over phenoxymethylpenicillin suspension in children due to superior palatability", "cautions": [ "MUST COMPLETE FULL 10-DAY COURSE to prevent acute rheumatic fever and post-streptococcal glomerulonephritis.", "Patient remains infectious until 24 hours after starting antibiotics.", "Contraindicated in penicillin allergy.", "Per day, not per dose. Read as a per-dose figure, 12.5-25 mg/kg at three doses a day reaches 75 mg/kg/day - nearly double the formulary's 40 mg/kg/day ceiling for an infection of this severity." ], "peds_mgkg_low": 20.0, "peds_mgkg_high": 40.0, "peds_max_mg": 1500.0, "peds_basis": "day", "peds_unit": "mg", "peds_note": "20-40 mg/kg/day divided every 8 hours, no single dose above 500 mg, for 10 days.", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": [ { "weight_kg": 10, "low_mg": 200, "high_mg": 400, "capped": false }, { "weight_kg": 20, "low_mg": 400, "high_mg": 800, "capped": false }, { "weight_kg": 30, "low_mg": 600, "high_mg": 1200, "capped": false }, { "weight_kg": 40, "low_mg": 800, "high_mg": 1500, "capped": true } ], "brands": [ { "trade_name": "AMOXYCILLIN 500MG 10 CAPS B.P.2013", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ARAB DRUG COMPANY (ADCO)", "price_egp": 6.5, "pack_count": 10, "unit_price": 0.65, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "AMOXICILLIN 500MG 12 CAPS. USP 28", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "OCTOBER PHARMA", "price_egp": 8.1, "pack_count": 12, "unit_price": 0.67, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "AMOXIL 500MG 12 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MUP > SMITHKLINE BEECHAM", "price_egp": 9.0, "pack_count": 12, "unit_price": 0.75, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "AMOXICID 500 MG 12 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "CID", "price_egp": 9.5, "pack_count": 12, "unit_price": 0.79, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "E-MOX 500 MG 16 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EIPICO", "price_egp": 15.6, "pack_count": 16, "unit_price": 0.97, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "HICONCIL 500MG 12 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "PHARCO", "price_egp": 11.6, "pack_count": 12, "unit_price": 0.97, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "BIOMOX 500MG 12 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "SEDICO", "price_egp": 19.5, "pack_count": 12, "unit_price": 1.62, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "IBIAMOX 500 MG 12 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "AMOUN", "price_egp": 45.0, "pack_count": 12, "unit_price": 3.75, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "HICILLIN 125MG/5ML SUSP. 80ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EL NASR", "price_egp": 3.0, "pack_count": null, "unit_price": null, "strength_mg": 125.0, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null }, { "trade_name": "AMOXIL FORT 250MG/5ML SUSP. 60ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MUP > SMITHKLINE BEECHAM", "price_egp": 5.5, "pack_count": null, "unit_price": null, "strength_mg": 250.0, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null } ], "condition_id": "scarlet-fever" }, { "id": 1636, "generic": "Referral & safety-netting (no drug therapy)", "line": 1, "is_adjunct": false, "form": null, "strength_mg": null, "adult_dose": null, "adult_duration": null, "dose_source": "Scarlet Fever - disease-level clinical article (scarlet-fever-full.txt)", "rationale": "Carries the referral criteria and warning signs for this condition, which apply whichever treatment is chosen.", "cautions": [ "RED FLAG - Hospitalization is indicated for severe or invasive infection or complications (abscess, toxic shock syndrome, necrotizing fasciitis), or inability to tolerate oral therapy." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": null, "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [], "condition_id": "scarlet-fever" }, { "id": 1637, "generic": "Phenoxymethyl penicillin", "line": 1, "is_adjunct": false, "form": "oral.solid", "strength_mg": 500.0, "adult_dose": "500 mg 2 to 3 times daily", "adult_duration": "10 days", "dose_source": "Egyptian National Drug Formulary - Antimicrobial 2023 (phenoxymethylpenicillin monograph)", "rationale": "Scarlet fever is group A streptococcal disease; the ENDF gives penicillin V a group-A-streptococcus pharyngitis regimen, and the disease article calls oral penicillin V co-first-line with amoxicillin.", "cautions": [ "Known hypersensitivity to any penicillin" ], "peds_mgkg_low": 25.0, "peds_mgkg_high": 50.0, "peds_max_mg": 2000.0, "peds_basis": "day", "peds_unit": "mg", "peds_note": "ENDF general paediatric dosing: 25 to 50 mg/kg/day in divided doses every 6 hours, maximum 2,000 mg/day. For group A streptococcal pharyngitis the ENDF gives 250 mg 2 to 3 times daily under 27 kg and 500 mg 2 to 3 times daily at 27 kg and above, for 10 days.", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": [ { "weight_kg": 10, "low_mg": 250, "high_mg": 500, "capped": false }, { "weight_kg": 20, "low_mg": 500, "high_mg": 1000, "capped": false }, { "weight_kg": 30, "low_mg": 750, "high_mg": 1500, "capped": false }, { "weight_kg": 40, "low_mg": 1000, "high_mg": 2000, "capped": false } ], "brands": [ { "trade_name": "OSPEN 1.0 MIU 12 F.C.TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "SANDOZ", "price_egp": 24.0, "pack_count": 12, "unit_price": 2.0, "strength_mg": null, "exact_strength": false, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "OSPEN 1.5 MIU 12 F.C.TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "SANDOZ", "price_egp": 41.0, "pack_count": 12, "unit_price": 3.42, "strength_mg": null, "exact_strength": false, "exact_form": true, "discontinued": false, "also_contains": null } ], "condition_id": "scarlet-fever" }, { "id": 1639, "generic": "Penicillin G benzathine", "line": 1, "is_adjunct": false, "form": "injection", "strength_mg": null, "adult_dose": "IM: 1.2 million units as a single dose", "adult_duration": "Single dose", "dose_source": "Egyptian National Drug Formulary - Antimicrobial 2023 (penicillin G benzathine monograph, group A streptococcal pharyngitis)", "rationale": "Scarlet fever is group A streptococcal disease, and the ENDF gives penicillin G benzathine an explicit group A streptococcal pharyngitis regimen. The disease article offers it for the patient who may not complete a full oral course.", "cautions": [ "Hypersensitivity to penicillin(s) or any component of the formulation", "The ENDF notes that empiric treatment is generally not recommended and that treatment should be prescribed only when testing confirms group A Streptococcus.", "Penicillin G benzathine is for intramuscular use only - never give intravenously." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "ENDF, group A streptococcal pharyngitis: children 27 kg or less, 600,000 units IM as a single dose; over 27 kg, 1.2 million units IM as a single dose.", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [ { "trade_name": "HAYA BENZ-R 1.2 M.I.U. VIAL FOR I.M INJ.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "SEDICO > HAYA PHARM-EGYPT", "price_egp": 5.06, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "PENICID LA 1 200 000 UNITS VIAL", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "CID", "price_egp": 6.5, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "BENZACILLIN 1.2 M.I.U.FOR I.M.INJ VIAL.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EL NASR", "price_egp": 7.0, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "RETARPEN 1.2 M.I.U. VIAL", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "SANDOZ > OCTOBER PHARMA", "price_egp": 10.5, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "LASTIPEN 1 200 000 IU VIAL", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MISR", "price_egp": 12.0, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "BENZABIOTIC 1.2 M.I.U. I.M. VIAL.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "SEDICO", "price_egp": 16.0, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "DEPO-PEN 1.2 MIU VIAL.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MUP", "price_egp": 25.0, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "PENCILONG (PENCITARD) 1200000 I.U./VIAL", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "NCPC NORTH BEST CO > ACDIMA INTERNATIONAL TRADING", "price_egp": 25.0, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null } ], "condition_id": "scarlet-fever" }, { "id": 1635, "generic": "Azithromycin", "line": 2, "is_adjunct": false, "form": "oral.solid", "strength_mg": 500.0, "adult_dose": "500 mg on day 1, followed by 250 mg once daily on days 2 through 5", "adult_duration": "5 days", "dose_source": "Egyptian National Drug Formulary, antimicrobial 2023, azithromycin monograph, paediatric dosing", "rationale": "First-line alternative in penicillin-allergic patients", "cautions": [ "Monitor for macrolide resistance and QT prolongation.", "The weight fields are deliberately empty. A flat mg/kg card cannot express a day-1 dose followed by a lower maintenance dose, and when it tried, it printed the day-1 figure for all five days - double what the child should get from day 2 onward.", "Azithromycin is second-line for penicillin-allergic patients." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "10-12 mg/kg once on day 1 (max 500 mg), then 5-6 mg/kg once daily (max 250 mg) for the rest of the course. It steps down - it is not the same dose every day.", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [ { "trade_name": "AZATRIBACT 500MG 3 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "RIVA PHARMA S.A.E.", "price_egp": 13.5, "pack_count": 3, "unit_price": 4.5, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "GIGAZOCIN 500MG 5 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EGPI > PIONEER", "price_egp": 27.5, "pack_count": 5, "unit_price": 5.5, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "SYSTYMYCIN 500MG 3 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EGPI > NOVELL PHARMA", "price_egp": 21.5, "pack_count": 3, "unit_price": 7.17, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "AZITHROMASH 500 MG 3 F.C. TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MASH PREMIERE", "price_egp": 48.0, "pack_count": 3, "unit_price": 16.0, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "AZALIDE 500MG 3 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "UP PHARMA", "price_egp": 52.0, "pack_count": 3, "unit_price": 17.33, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "AZROLID 500 MG 6 F.C.TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "AMRIYA", "price_egp": 126.0, "pack_count": 6, "unit_price": 21.0, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ZERAMERATE 500 MG", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EGPI > GAMMA PHARMA", "price_egp": 28.5, "pack_count": null, "unit_price": null, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "DISTABCIN 500 MG 3 DISPERSIBLE TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EGPI", "price_egp": 43.5, "pack_count": null, "unit_price": null, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ZITHRODOSE 100MG/5ML SUSP. 15ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EL-OBOUR > AVERROES PHARMA-EGYPT", "price_egp": 12.0, "pack_count": null, "unit_price": null, "strength_mg": 100.0, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null }, { "trade_name": "ZITHROPHATE 200MG/5ML SUSP. 15ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ORGANO PHARMA > NOVELL PHARMA", "price_egp": 12.75, "pack_count": null, "unit_price": null, "strength_mg": 200.0, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null } ], "condition_id": "scarlet-fever" }, { "id": 1638, "generic": "Clindamycin", "line": 2, "is_adjunct": false, "form": "oral.solid", "strength_mg": 150.0, "adult_dose": "150 to 300 mg every 6 hours", "adult_duration": null, "dose_source": "Egyptian National Drug Formulary - Antimicrobial 2023 (clindamycin monograph)", "rationale": "The disease article names clindamycin as the alternative for penicillin-allergic patients; the card's only non-penicillin option was azithromycin.", "cautions": [ "Hypersensitivity to clindamycin, lincomycin, or any component of the formulation", "The ENDF clindamycin monograph does not list pharyngitis among its indications and gives a general oral range rather than a group A streptococcal course - the indication and the need for a full 10-day course come from the disease article." ], "peds_mgkg_low": 8.0, "peds_mgkg_high": 20.0, "peds_max_mg": null, "peds_basis": "day", "peds_unit": "mg", "peds_note": "ENDF oral paediatric dosing, hydrochloride salt (capsule): 8 to 20 mg/kg/day divided every 6 to 8 hours.", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": [ { "weight_kg": 10, "low_mg": 80, "high_mg": 200, "capped": false }, { "weight_kg": 20, "low_mg": 160, "high_mg": 400, "capped": false }, { "weight_kg": 30, "low_mg": 240, "high_mg": 600, "capped": false }, { "weight_kg": 40, "low_mg": 320, "high_mg": 800, "capped": false } ], "brands": [ { "trade_name": "ADCOCLINDACE 150 MG 16 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ARAB DRUG COMPANY (ADCO)", "price_egp": 14.5, "pack_count": 16, "unit_price": 0.91, "strength_mg": 150.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ALFACLINDAMYCIN 150 MG 10 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ATCO PHARMA > ROTABIOGEN", "price_egp": 14.5, "pack_count": 10, "unit_price": 1.45, "strength_mg": 150.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "CLINACYN 150MG 16 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "SIGMA > EGYPTIAN PHARMACISTS COMPANY", "price_egp": 24.0, "pack_count": 16, "unit_price": 1.5, "strength_mg": 150.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "CLINDAM 150 MG 16 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "SIGMA > OCTOBER PHARMA", "price_egp": 28.5, "pack_count": 16, "unit_price": 1.78, "strength_mg": 150.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "CLINDACINE ART 150MG 12 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ART PHARMA", "price_egp": 27.5, "pack_count": 12, "unit_price": 2.29, "strength_mg": 150.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "MEPACLIND 150MG 16 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MEPACO", "price_egp": 48.0, "pack_count": 16, "unit_price": 3.0, "strength_mg": 150.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "KLENDABIOTICAM 1 % TOP. SOLUTION", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "PANAX PHARMA", "price_egp": 8.5, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null }, { "trade_name": "ADCOCLINDACE 10MG/ML TOP. SOL.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ARAB DRUG COMPANY (ADCO)", "price_egp": 12.0, "pack_count": null, "unit_price": null, "strength_mg": 10.0, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null } ], "condition_id": "scarlet-fever" } ] }