{ "schema_version": 1, "kind": "condition", "id": "roseola-infantum", "name": "Roseola Infantum (Exanthema Subitum)", "category": "infectious", "sources": "MSF Essential Drugs 2024 - paracetamol (oral) · NICE Clinical Knowledge Summaries: Roseola Infantum · WHO/UNICEF Joint Statement 2004 / WHO Diarrhoea Manual 2005 · WHO/UNICEF reduced-osmolarity oral rehydration salts (245 mOsm/L), recommended since 2002", "review_status": "reviewed", "verified_against": "MSF Essential Drugs 2024 - paracetamol (oral) · WHO/UNICEF Joint Statement 2004 / WHO Diarrhoea Manual 2005 · Roseola Infantum - disease-level clinical article (roseola-infantum-clinical.txt)", "verified_date": "2026-08", "treatments": [ { "id": 1620, "generic": "Paracetamol", "line": 1, "is_adjunct": false, "form": "oral.liquid", "strength_mg": 120.0, "adult_dose": "500-1000 mg three or four times a day as needed", "adult_duration": "3-4 days during febrile phase", "dose_source": "MSF Essential Drugs 2024 - paracetamol (oral)", "rationale": "Paracetamol is an antipyretic and analgesic used to control the high fever of roseola infantum and reduce the risk of febrile seizures; it does not treat the underlying viral infection, which is self-limiting.", "cautions": [ "The classic presentation is high fever for 3-5 days dropping abruptly, followed by a non-pruritic maculopapular rash on the trunk.", "High fever causes febrile seizures in 10-15% of cases; advise parents on fever management and seizure first aid.", "Reassure parents that condition is self-limiting and benign once rash appears.", "500 mg is the per-dose ceiling used here for a child. 1000 mg is the adult dose and does not belong in a weight calculation - the daily 60 mg/kg limit is the one that binds first in any case." ], "peds_mgkg_low": 15.0, "peds_mgkg_high": 15.0, "peds_max_mg": 500.0, "peds_basis": "dose", "peds_unit": "mg", "peds_note": "Give 15 mg/kg every 4-6 hours as needed; max 60 mg/kg daily Under 1 month: 10 mg/kg 3 or 4 times daily, maximum 40 mg/kg/day (MSF Essential Drugs 2024).", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": [ { "weight_kg": 10, "low_mg": 150, "high_mg": 150, "capped": false }, { "weight_kg": 20, "low_mg": 300, "high_mg": 300, "capped": false }, { "weight_kg": 30, "low_mg": 450, "high_mg": 450, "capped": false }, { "weight_kg": 40, "low_mg": 500, "high_mg": 500, "capped": true } ], "brands": [ { "trade_name": "CETAMOL 120MG/5ML PEDIATRIC SYRUP 120 ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MEMPHIS", "price_egp": 8.5, "pack_count": null, "unit_price": null, "strength_mg": 120.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "PARAGESIC BABY 120MG/5ML 120ML SUSP.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "AMRIYA", "price_egp": 36.0, "pack_count": null, "unit_price": null, "strength_mg": 120.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "PARAMOL 120MG/5ML SYRUP 125ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MISR", "price_egp": 36.0, "pack_count": null, "unit_price": null, "strength_mg": 120.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "FEBRIMOL ORAL DROPS 20 ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "PHARCO", "price_egp": 4.0, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null }, { "trade_name": "THERA-LO 3.2G/100ML ORAL SUSP. 100 ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "PHAROPHARMA", "price_egp": 5.0, "pack_count": null, "unit_price": null, "strength_mg": 3200.0, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null } ], "condition_id": "roseola-infantum" }, { "id": 1622, "generic": "Referral & safety-netting (no drug therapy)", "line": 1, "is_adjunct": false, "form": null, "strength_mg": null, "adult_dose": null, "adult_duration": null, "dose_source": "Roseola Infantum - disease-level clinical article (roseola-infantum-clinical.txt)", "rationale": "Carries the referral criteria and warning signs for this condition, which apply whichever treatment is chosen.", "cautions": [ "RED FLAG - Any of these needs medical assessment: a seizure with the fever; fever persisting beyond 4 days; fever that settles and then comes back; a child feeding badly or drying out; drowsiness or irritability beyond what the illness explains; or anything pointing towards meningitis.", "RED FLAG - Febrile infants aged 8-60 days without the characteristic rash should follow age-specific fever protocols to rule out serious bacterial infection before a roseola diagnosis is assumed." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": null, "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [], "condition_id": "roseola-infantum" }, { "id": 1621, "generic": "ORS", "line": 1, "is_adjunct": true, "form": "oral.liquid", "strength_mg": null, "adult_dose": "Sip fluid/ORS solution as needed", "adult_duration": "3-4 days", "dose_source": "WHO/UNICEF Joint Statement 2004 / WHO Diarrhoea Manual 2005", "rationale": "Oral rehydration salts are given alongside antipyretic care to maintain fluid and electrolyte balance during the febrile illness of roseola; they do not treat the underlying viral cause.", "cautions": [ "Ensure adequate oral fluid intake.", "Watch for signs of dehydration or lethargy.", "Use the reduced-osmolarity formulation (sodium 75, glucose 75, potassium 20, citrate 10, chloride 65 mmol/L; 245 mOsm/L). WHO replaced the older 311 mOsm/L formula in 2002 for diarrhoea of any cause at any age - it cuts stool output and vomiting." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "Offer small frequent fluid sips to prevent dehydration during high fever", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [ { "trade_name": "GLUCOHYDRAN 10 SACHET.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ARAB DRUG COMPANY (ADCO)", "price_egp": 1.75, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "REHYDRAN N 10 SACHET", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "CID", "price_egp": 4.5, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "REHYDRO ZINC 10 SACHETS", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "CID", "price_egp": 7.0, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ORS 20 SACHETS", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "PHAROPHARMA", "price_egp": 40.0, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ELECTRO MASH SYRUP 200 ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MASH PREMIERE", "price_egp": 60.0, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "FLEXOLYTE ORAL REHYDRATION SOL. 240 ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "KEMPETRO FOR CHEMICAL INDUSTRIES", "price_egp": 65.0, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "HERO ORS 200 ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "HERO > HERO MEA TRADING", "price_egp": 120.0, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "SANSO ORS SYRUP 140 ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "AUG PHARMA", "price_egp": 400.0, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null } ], "condition_id": "roseola-infantum" } ] }