{ "schema_version": 1, "kind": "condition", "id": "raynaud-phenomenon", "name": "Raynaud's Phenomenon (Primary)", "category": "chronic", "sources": "BSR and BHPR guideline for the management of Raynaud's phenomenon 2015 · Egyptian National Drug Formulary - Cardiovascular 2024 (amlodipine monograph) · Egyptian National Drug Formulary - Cardiovascular 2024 (nifedipine monograph)", "review_status": "reviewed", "verified_against": "Egyptian National Drug Formulary - Cardiovascular 2024 (nifedipine monograph) · Egyptian National Drug Formulary - Cardiovascular 2024 (amlodipine monograph)", "verified_date": "2026-08", "treatments": [ { "id": 1580, "generic": "Nifedipine", "line": 1, "is_adjunct": false, "form": "oral.solid", "strength_mg": 20.0, "adult_dose": "20 mg twice daily (modified-release retard formulation, e.g. Epilat Retard)", "adult_duration": "long-term during cold season", "dose_source": "Egyptian National Drug Formulary - Cardiovascular 2024 (nifedipine monograph)", "rationale": "Modified-release formulation (e.g. Epilat Retard 20 mg SR) is preferred over short-acting immediate-release 10 mg soft-gel capsules to avoid precipitous vasodilation and reflex tachycardia.", "cautions": [ "MANDATORY to exclude secondary Raynaud's (red flags: digital ulcers, tissue necrosis, asymmetrical attacks, late onset >30y, sclerodactyly, positive ANA); prompt rheumatology referral if suspected.", "CONTRAINDICATED in severe hypotension, cardiogenic shock, and severe aortic stenosis; avoid short-acting immediate-release capsules.", "Emphasize non-pharmacological measures (keep extremities warm, smoking cessation, avoid sympathomimetics and beta-blockers); common adverse effects include flushing, headache, and ankle edema.", "The Egyptian formulary doses the once-daily extended-release nifedipine at 30-60 mg, maximum 120 mg daily. The 20 mg twice-daily retard preparation specified here is a different product - do not read the two as interchangeable." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "Specialist pediatric rheumatology evaluation", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [ { "trade_name": "EPILAT RETARD 20MG SR. 20 F.C.TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EIPICO", "price_egp": 22.0, "pack_count": 20, "unit_price": 1.1, "strength_mg": 20.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null } ], "condition_id": "raynaud-phenomenon" }, { "id": 1581, "generic": "Amlodipine", "line": 2, "is_adjunct": false, "form": "oral.solid", "strength_mg": 5.0, "adult_dose": "5-10 mg once daily", "adult_duration": "long-term", "dose_source": "Egyptian National Drug Formulary - Cardiovascular 2024 (amlodipine monograph)", "rationale": "Amlodipine is a dihydropyridine calcium channel blocker that dilates peripheral arteries, reducing the frequency and severity of the vasospastic attacks characteristic of primary Raynaud's phenomenon.", "cautions": [ "MANDATORY to rule out secondary Raynaud's and connective tissue disease (digital ulceration, tissue loss, scleroderma features).", "CONTRAINDICATED in severe hypotension and cardiogenic shock.", "Monitor for peripheral edema, headache, and dizziness; emphasize cold avoidance and smoking cessation." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "Specialist use only", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [ { "trade_name": "CORONAVINE 5 MG 10 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "PHAROPHARMA", "price_egp": 6.0, "pack_count": 10, "unit_price": 0.6, "strength_mg": 5.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "WINDIPINE 5 MG 30 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "SANOFI", "price_egp": 21.0, "pack_count": 30, "unit_price": 0.7, "strength_mg": 5.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "VASOPINE 5 MG 30 TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ARAB DRUG COMPANY (ADCO)", "price_egp": 24.0, "pack_count": 30, "unit_price": 0.8, "strength_mg": 5.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "AMILO 5 MG 30 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ALFACURE PHARMACEUTICALS", "price_egp": 54.0, "pack_count": 30, "unit_price": 1.8, "strength_mg": 5.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "AMLODIPINE 5 MG 30 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "AMRIYA", "price_egp": 60.0, "pack_count": 30, "unit_price": 2.0, "strength_mg": 5.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "MYODURA 5 MG 30 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "GLOBAL NAPI PHARMACEUTICALS > WOCKHARDT", "price_egp": 69.0, "pack_count": 30, "unit_price": 2.3, "strength_mg": 5.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "NORVASC 5MG 10 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "PFIZER > VIATRIS EGYPT", "price_egp": 54.0, "pack_count": 10, "unit_price": 5.4, "strength_mg": 5.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "NORVASC 5MG 30 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "PFIZER > VIATRIS EGYPT", "price_egp": 162.0, "pack_count": 30, "unit_price": 5.4, "strength_mg": 5.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null } ], "condition_id": "raynaud-phenomenon" } ] }