{ "schema_version": 1, "kind": "condition", "id": "pyelonephritis", "name": "Acute uncomplicated pyelonephritis", "category": "infectious", "sources": "IDSA Guidelines for Uncomplicated UTI and Pyelonephritis 2011 · Egyptian National Drug Formulary - Antimicrobial 2023 (cefixime monograph) · Pyelonephritis - disease-level clinical article (pyelonephritis-full.txt) · Egyptian National Drug Formulary - Antimicrobial 2023 (ciprofloxacin monograph, acute pyelonephritis), with the 14-day male course from Pyelonephritis - disease-level clinical article (pyelonephritis-full.txt) · Egyptian National Drug Formulary - Antimicrobial 2023 (Version 1.0), sulfamethoxazole and trimethoprim monograph, Indications (\"Treatment of urinary tract infections (UTIs)\") and Dosage Regimen, Dosing: Adult, General dosing guidelines, with the 14-day course from Pyelonephritis - disease-level clinical article (pyelonephritis-full.txt) · Egyptian National Drug Formulary - Antimicrobial 2023 (ceftriaxone monograph) · Egyptian National Drug Formulary - Antimicrobial 2023 (gentamicin monograph)", "review_status": "reviewed", "verified_against": "Egyptian National Drug Formulary - Antimicrobial 2023 (cefixime monograph) · Acute Pyelonephritis - disease-level clinical article (pyelonephritis-clinical.txt) · Pyelonephritis - disease-level clinical article (pyelonephritis-full.txt) · Egyptian National Drug Formulary - Antimicrobial 2023 (ciprofloxacin monograph, acute pyelonephritis), with the 14-day male course from Pyelonephritis - disease-level clinical article (pyelonephritis-full.txt) · Egyptian National Drug Formulary - Antimicrobial 2023 (Version 1.0), sulfamethoxazole and trimethoprim monograph, Indications (\"Treatment of urinary tract infections (UTIs)\") and Dosage Regimen, Dosing: Adult, General dosing guidelines, with the 14-day course from Pyelonephritis - disease-level clinical article (pyelonephritis-full.txt)", "verified_date": "2026-08", "treatments": [ { "id": 1567, "generic": "Ciprofloxacin", "line": 1, "is_adjunct": false, "form": "oral.solid", "strength_mg": 500.0, "adult_dose": "500 mg orally twice daily", "adult_duration": "7 days; 14 days in male patients", "dose_source": "Egyptian National Drug Formulary - Antimicrobial 2023 (ciprofloxacin monograph, acute pyelonephritis), with the 14-day male course from Pyelonephritis - disease-level clinical article (pyelonephritis-full.txt)", "rationale": "Ciprofloxacin is a fluoroquinolone that reaches high concentrations in the urinary tract and renal tissue, making it a first-line oral option for acute uncomplicated pyelonephritis outside of pregnancy. The disease article doubles the course in men - a fluoroquinolone for 7 days, and 14 days where the patient is male - where the Egyptian formulary gives 5 to 7 days for everyone; the international figure leads and the formulary's is on the row.", "cautions": [ "Avoid in pregnancy (use ceftriaxone or cefixime instead).", "Admit to hospital if vomiting, septic, pregnant, or failing oral therapy after 48h.", "Men need the longer course. The disease article's outpatient regimen applies where quinolone resistance in community-acquired infection runs at 10% or under: a fluoroquinolone for 7 days, extended to 14 days in a man.", "The Egyptian formulary gives no separate male course - for acute pyelonephritis or another complicated UTI it lists the immediate-release oral form at 500 mg, one dose every 12 hours, and 5 to 7 days in all, with no distinction by sex.", "The article adds that where community fluoroquinolone resistance exceeds 10%, an initial parenteral dose (for example ceftriaxone) should precede the oral course.", "There is a risk of tendonitis, tendon rupture, and QT prolongation." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "Mild to moderate infections: Oral, immediate release: 10 mg/kg/dose twice daily; maximum dose: 500 mg/dose.", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [ { "trade_name": "QUINOLOROX 500MG 10 F.C. TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EPCI > ROXXEN", "price_egp": 10.0, "pack_count": 10, "unit_price": 1.0, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ECACIPROFLOX 500 MG 20 F.C. TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "FUTURE PHARMACEUTICAL INDUSTRIES (FPI) > EGYPTIAN CANADIAN PHARMACEUTICAL", "price_egp": 27.0, "pack_count": 20, "unit_price": 1.35, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ELMODOXACIN 500MG 10 F.C.TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EGPI > SEA PHARM", "price_egp": 20.0, "pack_count": 10, "unit_price": 2.0, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "CIPROQUIN 500MG 10 F.C. TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "UNIPHARMA", "price_egp": 50.0, "pack_count": 10, "unit_price": 5.0, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "CIPROFLOXACIN-ORGANO 500 MG 10 F.C.TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ORGANOPHARMA > ORGANO", "price_egp": 63.0, "pack_count": 10, "unit_price": 6.3, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "CIPROFAR 500MG 10 F.C.TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "PHARCO", "price_egp": 69.0, "pack_count": 10, "unit_price": 6.9, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "CIPROMEGA XL 500MG 10 EXT. REL. F.C.TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MASH PREMIERE", "price_egp": 48.0, "pack_count": null, "unit_price": null, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "HEROXACIN 500MG 10 SCORED F.C. TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EGPI > HERO PHARM", "price_egp": 69.0, "pack_count": null, "unit_price": null, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null } ], "condition_id": "pyelonephritis" }, { "id": 1568, "generic": "Referral & safety-netting (no drug therapy)", "line": 1, "is_adjunct": false, "form": null, "strength_mg": null, "adult_dose": null, "adult_duration": null, "dose_source": "Acute Pyelonephritis - disease-level clinical article (pyelonephritis-clinical.txt)", "rationale": "Carries the referral criteria and warning signs for this condition, which apply whichever treatment is chosen.", "cautions": [ "RED FLAG - The indications for hospital admission rather than outpatient oral antibiotics are sepsis, high fever, uncontrolled pain, persistent vomiting, immunocompromise, pregnancy, poorly controlled diabetes, transplant recipients, or suspected obstruction.", "RED FLAG - Obstructive pyelonephritis (pyonephrosis) is a surgical emergency needing urgent drainage, not antibiotics alone." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": null, "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [], "condition_id": "pyelonephritis" }, { "id": 1569, "generic": "Sulphamethoxazole + Trimethoprim", "line": 2, "is_adjunct": false, "form": "oral.solid", "strength_mg": 800.0, "adult_dose": "1 to 2 double-strength tablets every 12 to 24 hours", "adult_duration": "14 days", "dose_source": "Egyptian National Drug Formulary - Antimicrobial 2023 (Version 1.0), sulfamethoxazole and trimethoprim monograph, Indications (\"Treatment of urinary tract infections (UTIs)\") and Dosage Regimen, Dosing: Adult, General dosing guidelines, with the 14-day course from Pyelonephritis - disease-level clinical article (pyelonephritis-full.txt)", "rationale": "The card offered ciprofloxacin and nothing else, so a patient in whom a fluoroquinolone is unsuitable had no oral antibiotic at all. The disease article names the American College of Physicians recommendation of sulfamethoxazole-trimethoprim as the first-line alternative to a fluoroquinolone, and gives the course as 14 days. The ENDF indicates the combination for urinary tract infections caused by E. coli, Klebsiella, Enterobacter, Morganella and Proteus, and supplies the tablet figure, but states no duration at all and does not distinguish upper from lower urinary tract infection - it says 'urinary tract infections' and pyelonephritis is one. The 14 days on this row is therefore the article's figure, leading under the 2026-08-16 source ruling, and the citation names both documents. The ENDF lists tablets of 400/80 mg and 800/160 mg; 'double-strength' is the 800/160 mg tablet.", "cautions": [ "Hypersensitivity to any sulfa drug, trimethoprim, or any component of the formulation; history of drug induced-immune thrombocytopenia with use of sulfonamides or trimethoprim; megaloblastic anemia due to folate deficiency; infants <2 months", "Additional contraindications: Blood dyscrasias; pregnancy; breastfeeding; premature infants; acute porphyria.", "Serum creatinine and potassium concentrations should be monitored in outpatients receiving high-dose therapy.", "Adults with Clcr 15-30 mL/minute: Reduce dose to ~50% of usual dose.", "The formulary states no duration for this indication; the 14-day course named in the disease article is the American College of Physicians' recommendation, not the formulary's.", "The 14 days is the disease article's figure: in uncomplicated pyelonephritis the American College of Physicians puts sulfamethoxazole-trimethoprim at 14 days, or a fluoroquinolone at 5 to 7 days, the choice resting on local resistance patterns and on the sensitivities the urine culture returns." ], "peds_mgkg_low": 6.0, "peds_mgkg_high": 12.0, "peds_max_mg": 320.0, "peds_basis": "day", "peds_unit": "mg", "peds_note": "ENDF general dosing, susceptible infection, infants 2 months and over, children and adolescents: oral 6 to 12 mg TMP/kg/day in divided doses every 12 hours, maximum single dose 160 mg TMP. The mg/kg figures are the TRIMETHOPRIM component, not the combined tablet. Contraindicated in infants under 2 months.", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": [ { "label": "2 months and over", "age_min_months": 2, "age_max_months": 216, "dose_text": "6 to 12 mg trimethoprim/kg/day in divided doses every 12 hours, maximum single dose 160 mg trimethoprim. Contraindicated under 2 months." } ], "peds_doses": [ { "weight_kg": 10, "low_mg": 60, "high_mg": 120, "capped": false }, { "weight_kg": 20, "low_mg": 120, "high_mg": 240, "capped": false }, { "weight_kg": 30, "low_mg": 180, "high_mg": 320, "capped": true }, { "weight_kg": 40, "low_mg": 240, "high_mg": 320, "capped": true } ], "brands": [ { "trade_name": "CO-TRIMOXAZOLE 20 TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MUP", "price_egp": 5.0, "pack_count": 20, "unit_price": 0.25, "strength_mg": null, "exact_strength": false, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "COTRIL 400/80MG 20 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EL NASR", "price_egp": 38.0, "pack_count": 20, "unit_price": 1.9, "strength_mg": 80.0, "exact_strength": false, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "SEPTAZOLE FORTE 800/160MG 20 TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ALEXANDRIA", "price_egp": 56.0, "pack_count": 20, "unit_price": 2.8, "strength_mg": 160.0, "exact_strength": false, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "SEPTRIN D.S 10 TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "GLAXO SMITHKLINE > ASPEN PHARMA TRADING LIMITED", "price_egp": 28.0, "pack_count": 10, "unit_price": 2.8, "strength_mg": null, "exact_strength": false, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "SEPTAZOLE 400/80MG 20*10 TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ALEXANDRIA", "price_egp": 340.0, "pack_count": 10, "unit_price": 34.0, "strength_mg": 80.0, "exact_strength": false, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "SUTRIM 400/80MG 20*10 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MEMPHIS", "price_egp": 340.0, "pack_count": 10, "unit_price": 34.0, "strength_mg": 80.0, "exact_strength": false, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "CO-TRIMOXAZOLE 200/40MG SUSP. 120ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MUP", "price_egp": 6.0, "pack_count": null, "unit_price": null, "strength_mg": 40.0, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null }, { "trade_name": "SUTRIM 200/40MG SUSP. 100ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MEMPHIS", "price_egp": 18.5, "pack_count": null, "unit_price": null, "strength_mg": 40.0, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null } ], "condition_id": "pyelonephritis" }, { "id": 1570, "generic": "Amoxicillin + Clavulanic acid", "line": 2, "is_adjunct": false, "form": "oral.solid", "strength_mg": 1000.0, "adult_dose": "875/125 mg orally twice daily", "adult_duration": "7 to 10 days", "dose_source": "Acute Pyelonephritis - StatPearls - NCBI Bookshelf (NBK519537) - disease-level clinical article (pyelonephritis-full.txt) - verbatim: \"If quinolone resistance in community-acquired infections is greater than 10%, choose one of the following (assuming bacterial sensitivity): Amoxicillin-clavulanate 875 mg orally twice daily for 7 to 10 days\", under the heading \"Appropriate empiric antibiotics for outpatients with acute pyelonephritis include\".", "rationale": "The oral option to reach for when a fluoroquinolone is not appropriate - because local resistance is above 10%, or the patient cannot take one. Co-amoxiclav covers the Enterobacteriaceae that cause most pyelonephritis while sparing the quinolone class.", "cautions": [ "This is the branch for community quinolone resistance above 10%. Where it is 10% or under, the fluoroquinolone above is the first-line choice.", "Send a urine culture before the first dose and change to a narrower agent once sensitivities are back - the source is explicit that therapy should be narrowed whenever it safely can be.", "Oral therapy is for the outpatient who is not septic. Admit for sepsis, high fever, uncontrolled pain, persistent vomiting, immunocompromise, pregnancy, poorly controlled diabetes, transplant, or suspected obstruction.", "Review at 24 to 48 hours. Failure to improve on oral therapy is itself an indication for admission." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "No paediatric dose is available from this source, which states the outpatient regimen for adults and gives no mg/kg figure.", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [ { "trade_name": "E-MOXCLAV 1G 10 F.C. TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EIPICO", "price_egp": 14.0, "pack_count": 10, "unit_price": 1.4, "strength_mg": 1000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "JULMENTIN 2X 1GM 15 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "JULPHAR", "price_egp": 57.5, "pack_count": 15, "unit_price": 3.83, "strength_mg": 1000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "DEXICLAVE 1 GM 10 F.C. TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "RAMEDA > NOVELL PHARMA", "price_egp": 38.5, "pack_count": 10, "unit_price": 3.85, "strength_mg": 1000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "MACLAVEX 1 GM 14 F.C.TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MASH PREMIERE", "price_egp": 105.0, "pack_count": 14, "unit_price": 7.5, "strength_mg": 1000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "CLAVIMOX 1 GM 12 F.C.TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "PHARCO", "price_egp": 130.0, "pack_count": 12, "unit_price": 10.83, "strength_mg": 1000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "MEGAMOX 1 GM 14 F.C. TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "AL JAZEERA PHARMACEUTICAL > HIKMA PHARMA", "price_egp": 178.0, "pack_count": 14, "unit_price": 12.71, "strength_mg": 1000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "CLAVOCILLIN 1 GM 10 DISPERSIBLE TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "RAMEDA > ORGANOPHARMA", "price_egp": 106.0, "pack_count": null, "unit_price": null, "strength_mg": 1000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "AUGMENTIN ADULTS 1GM/125MG 12 PWD. ORAL SUSP. SACHETS", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "GLAXO SMITHKLINE", "price_egp": 169.0, "pack_count": null, "unit_price": null, "strength_mg": 1000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "LARYNCLAVE 125/31 PD. FOR ORAL SUSP. 70ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MISR > AL ROWAD PHARMACEUTICAL INDUSTRIAL CO.", "price_egp": 8.0, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null }, { "trade_name": "MEGACLAVOX 156MG/5ML PD. FOR SUSP. 60 ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "CID", "price_egp": 8.0, "pack_count": null, "unit_price": null, "strength_mg": 156.0, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null } ], "condition_id": "pyelonephritis" }, { "id": 1571, "generic": "Cefadroxil", "line": 2, "is_adjunct": false, "form": "oral.solid", "strength_mg": 1000.0, "adult_dose": "1 g orally twice daily", "adult_duration": "7 to 10 days", "dose_source": "Acute Pyelonephritis - StatPearls - NCBI Bookshelf (NBK519537) - disease-level clinical article (pyelonephritis-full.txt) - verbatim: \"If quinolone resistance in community-acquired infections is greater than 10%, choose one of the following (assuming bacterial sensitivity): ... Cefadroxil 1 g orally twice daily for 7 to 10 days\", under the heading \"Appropriate empiric antibiotics for outpatients with acute pyelonephritis include\".", "rationale": "The cephalosporin option in the same list, for the patient who cannot take co-amoxiclav. The 1 g tablet is stocked widely and cheaply in Egypt.", "cautions": [ "This is the branch for community quinolone resistance above 10%. Where it is 10% or under, the fluoroquinolone above is the first-line choice.", "1 g twice a day, not the 500 mg twice a day used for skin and throat infections. The kidney dose is the higher one.", "Send a urine culture before the first dose and narrow the agent once sensitivities are back.", "Avoid after a severe or immediate reaction to a penicillin. Cephalosporins carry a cross-reactivity risk, and this source does not quantify it, so no figure is given here." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "No paediatric dose is available from this source, which states the outpatient regimen for adults and gives no mg/kg figure.", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [ { "trade_name": "CEFIX 1000MG 8 F.C.TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "SIGMA TEC > FUTURE PHARMACEUTICAL INDUSTRIES (FPI)", "price_egp": 10.0, "pack_count": 8, "unit_price": 1.25, "strength_mg": 1000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "BIODROXIL 1 GM 8 F.C.TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "KAHIRA > NOVARTIS", "price_egp": 15.0, "pack_count": 8, "unit_price": 1.88, "strength_mg": 1000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "CEFEX 1 GM 8 F.C.TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "SIGMA TEC > FUTURE PHARMACEUTICAL INDUSTRIES (FPI)", "price_egp": 22.5, "pack_count": 8, "unit_price": 2.81, "strength_mg": 1000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "CURISAFE 1 GM 8 F.C. TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "PHARCO B", "price_egp": 76.0, "pack_count": 8, "unit_price": 9.5, "strength_mg": 1000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "DURICEF 1 GM 8 F.C. TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "SMITHKLINE BEECHAM", "price_egp": 78.0, "pack_count": 8, "unit_price": 9.75, "strength_mg": 1000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "CEFADROXIL 1 GM 6 DISPERSIBLE TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "SIGMA", "price_egp": 12.0, "pack_count": null, "unit_price": null, "strength_mg": 1000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "DURICEF 1 GM 6 DISPERSABLE TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "SMITHKLINE BEECHAM", "price_egp": 58.0, "pack_count": null, "unit_price": null, "strength_mg": 1000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "LONGICEF 125MG/5ML SUSP. 60 ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "KAHIRA", "price_egp": 4.25, "pack_count": null, "unit_price": null, "strength_mg": 125.0, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null }, { "trade_name": "CEFADROXIL 250MG/5ML PD. FOR ORAL SUSP. 60ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "SIGMA", "price_egp": 7.5, "pack_count": null, "unit_price": null, "strength_mg": 250.0, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null } ], "condition_id": "pyelonephritis" }, { "id": 1572, "generic": "Ceftriaxone", "line": 1, "is_adjunct": true, "form": "injection", "strength_mg": null, "adult_dose": "1 to 2 g as a single intramuscular or intravenous dose", "adult_duration": "single dose", "dose_source": "Egyptian National Drug Formulary - Antimicrobial 2023 (ceftriaxone monograph) - verbatim: \"General Adult Dosage IV or IM 1-2 g once or devided twice daily.\"", "rationale": "One intramuscular dose in the clinic covers the patient while the culture is pending and the first oral doses take hold, which is what the guideline bodies advise wherever local resistance to the oral agents is common. It is given with the oral course, never instead of it.", "cautions": [ "Do not give it to anyone who has had anaphylaxis to ceftriaxone, another cephalosporin, a penicillin or any other beta-lactam.", "It is an add-on: start the oral course as well, and review the patient against the urine culture." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "Adults only; a child with pyelonephritis needs referral rather than a clinic dose.", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [ { "trade_name": "CEFAXONE 250MG I.V. VIAL.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "PHARCO B", "price_egp": 15.0, "pack_count": null, "unit_price": null, "strength_mg": 250.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "CEFOTRIX 250MG I.V.VIAL (U.S.P.23)", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "UP PHARMA", "price_egp": 15.0, "pack_count": null, "unit_price": null, "strength_mg": 250.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "TRIXOMASH 500MG VIAL FOR I.V. INJ.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "RAMEDA > MASH PREMIERE", "price_egp": 16.5, "pack_count": null, "unit_price": null, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "TRIAXONE 500MG VIAL FOR I.M. INJ.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "TABUK PHARMACEUTICAL MANUFACTURING COMPANY > TABUK PHARMA", "price_egp": 36.0, "pack_count": null, "unit_price": null, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "WINTRIAXONE 1 GM PD. FOR I.M INJ.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "SANOFI", "price_egp": 48.0, "pack_count": null, "unit_price": null, "strength_mg": 1000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "CEFTRIAXONE-SANDOZ 500 MG I.M. VIAL", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "PHARCO B > SANDOZ", "price_egp": 62.0, "pack_count": null, "unit_price": null, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "TRIAXONE 1 GM I.M. VIAL", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "TABUK PHARMACEUTICAL MANUFACTURING COMPANY > TABUK PHARMA", "price_egp": 106.0, "pack_count": null, "unit_price": null, "strength_mg": 1000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "TRIAXONE 1 GM I.V VIAL", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "TABUK PHARMACEUTICAL MANUFACTURING COMPANY > TABUK PHARMA", "price_egp": 106.0, "pack_count": null, "unit_price": null, "strength_mg": 1000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null } ], "condition_id": "pyelonephritis" }, { "id": 1573, "generic": "Gentamicin", "line": 2, "is_adjunct": true, "form": "injection", "strength_mg": null, "adult_dose": "5 mg/kg as a single dose", "adult_duration": "single dose", "dose_source": "Egyptian National Drug Formulary - Antimicrobial 2023 (gentamicin monograph) - verbatim: \"Outpatients: IV, IM: 5 mg/kg once, followed by 5 to 14 days of appropriate oral therapy\"", "rationale": "A cheap, widely stocked alternative to a stat ceftriaxone dose where a gram-negative organism is likely, and the one aminoglycoside use that needs no serum level monitoring because it is a single dose. It is added to the oral course, not substituted for it.", "cautions": [ "Weigh the patient - the dose is per kilogram, and a guessed weight is the usual cause of an aminoglycoside overdose.", "Aminoglycosides can damage hearing and cause tinnitus; that risk goes with sustained high levels, which is why it is given as one dose and not a course.", "Use caution when the creatinine clearance is under 40 mL/min, and avoid it in pregnancy." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "Adults only; a child with pyelonephritis needs referral rather than a clinic dose.", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [ { "trade_name": "REFOBACIN 40MG 3 AMP.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "GLAXO SMITHKLINE > MERCK KGAA F.R.GERMANY", "price_egp": 6.0, "pack_count": null, "unit_price": null, "strength_mg": 40.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "REFOBACIN 80MG 3 AMP.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "GLAXO SMITHKLINE > MERCK KGAA F.R.GERMANY", "price_egp": 9.0, "pack_count": null, "unit_price": null, "strength_mg": 80.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "GENTAMICIN-ALEX 20MG/2ML 6 AMP.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ALEXANDRIA", "price_egp": 12.0, "pack_count": null, "unit_price": null, "strength_mg": 20.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "EPIGENT 20MG/2ML I.V./I.M. 3 AMPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EIPICO", "price_egp": 24.0, "pack_count": null, "unit_price": null, "strength_mg": 20.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "GENTAMICIN-ALEX 80MG/2ML 3 AMP. I.M/I.V INJ.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ALEXANDRIA", "price_egp": 52.5, "pack_count": null, "unit_price": null, "strength_mg": 80.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "EPIGENT 80MG/2ML I.M./I.V. 3 AMPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EIPICO", "price_egp": 54.0, "pack_count": null, "unit_price": null, "strength_mg": 80.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "GARAMYCIN 20MG/2ML 6 AMPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MEMPHIS", "price_egp": 66.0, "pack_count": null, "unit_price": null, "strength_mg": 20.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "GARAMYCIN 40MG/ML 6 AMPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MEMPHIS", "price_egp": 72.0, "pack_count": null, "unit_price": null, "strength_mg": 40.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null } ], "condition_id": "pyelonephritis" } ] }