{ "schema_version": 1, "kind": "condition", "id": "post-nasal-drip", "name": "Post-nasal drip syndrome (upper airway cough syndrome)", "category": "chronic", "sources": "ACCP Cough Guideline: Upper Airway Cough Syndrome 2006 · Egyptian National Drug Formulary - Respiratory System 2026 (cetirizine monograph) · eMC SmPC, Neoclarityn 5 mg film-coated tablets (Organon), sections 4.1 and 4.2", "review_status": "reviewed", "verified_against": "ACCP Cough Guideline: Upper Airway Cough Syndrome 2006 · Egyptian National Drug Formulary - Respiratory System 2026 (cetirizine monograph) · eMC SmPC, Neoclarityn 5 mg film-coated tablets (Organon), sections 4.1 and 4.2", "verified_date": "2026-08", "treatments": [ { "id": 1497, "generic": "Fluticasone propionate", "line": 1, "is_adjunct": false, "form": "nasal", "strength_mg": null, "adult_dose": "2 sprays (100 mcg) into each nostril once daily, preferably in the morning", "adult_duration": "2-4 weeks", "dose_source": "ACCP Cough Guideline: Upper Airway Cough Syndrome 2006", "rationale": "Intranasal fluticasone reduces inflammation of the nasal and sinus mucosa that drives post-nasal drip and the resulting cough, and is first-line therapy for upper airway cough syndrome.", "cautions": [ "Full therapeutic benefit requires regular daily use for several days.", "Direct spray away from nasal septum to avoid epistaxis.", "Systemic effects are rare at recommended intranasal doses." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "Children >4 years: 1 spray into each nostril once daily", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [ { "trade_name": "RHINORELIEF NASAL SUSP. 50 MCG/METERED SPRAY DOSE", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ARAB DRUG COMPANY (ADCO)", "price_egp": 32.0, "pack_count": null, "unit_price": null, "strength_mg": 0.05, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "TICANASE 0.05% NASAL SPRAY 12 GM", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EUROPEAN EGYPTIAN PHARM. IND.", "price_egp": 70.0, "pack_count": null, "unit_price": null, "strength_mg": 12000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "FLIX NASAL SPRAY 50 MCG/METERED SPRAY DOSE", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EVA PHARMA", "price_egp": 76.0, "pack_count": null, "unit_price": null, "strength_mg": 0.05, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "FLIXOTIDE 0.5MG/2ML 10 INH. NEBULES", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "GLAXO SMITHKLINE", "price_egp": 63.0, "pack_count": null, "unit_price": null, "strength_mg": 0.5, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "FLOHALE HFA 250MCG/DOSE AEROSOL 120 DOSES", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "CIPLA LTD. - INDIA > STAR INTERNATIONAL COMPANY", "price_egp": 95.0, "pack_count": null, "unit_price": null, "strength_mg": 0.25, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "FLIXOTIDE EVOHALER 50MCG/ACTUATION INHALER", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "GLAXO SMITHKLINE", "price_egp": 111.0, "pack_count": null, "unit_price": null, "strength_mg": 0.05, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "FLIXOTIDE DISKUS 250 MCG/DOSE 60 DOSES", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "GLAXO SMITHKLINE", "price_egp": 150.0, "pack_count": null, "unit_price": null, "strength_mg": 0.25, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "FLIXOTIDE 2MG/2ML 10 INH. NEBULES", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "GLAXO SMITHKLINE", "price_egp": 214.25, "pack_count": null, "unit_price": null, "strength_mg": 2.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null } ], "condition_id": "post-nasal-drip" }, { "id": 1498, "generic": "Cetirizine", "line": 2, "is_adjunct": false, "form": "oral.solid", "strength_mg": 10.0, "adult_dose": "10 mg once daily", "adult_duration": "2-4 weeks", "dose_source": "Egyptian National Drug Formulary - Respiratory System 2026 (cetirizine monograph)", "rationale": "Cetirizine is a second-generation antihistamine that blocks histamine-mediated nasal secretion and drainage; it is used as a second-line or alternative option to intranasal corticosteroids for post-nasal drip, particularly when an allergic trigger is suspected.", "cautions": [ "May cause mild drowsiness in susceptible individuals; caution driving.", "Reduce dose in renal impairment.", "Avoid concurrent alcohol or CNS depressants." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "Children 2-6 years: 2.5 mg twice daily; 6-12 years: 5 mg twice daily", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": [ { "label": "2 to under 6 years", "age_min_months": 24, "age_max_months": 71, "dose_text": "2.5 mg twice daily" }, { "label": "6 to under 12 years", "age_min_months": 72, "age_max_months": 143, "dose_text": "5 mg twice daily" } ], "peds_doses": null, "brands": [ { "trade_name": "EPIRIZINE 10 MG 10 TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EIPICO", "price_egp": 15.5, "pack_count": 10, "unit_price": 1.55, "strength_mg": 10.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "CETRITIN 10MG 20 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EL NILE.", "price_egp": 42.0, "pack_count": 20, "unit_price": 2.1, "strength_mg": 10.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "TOMAZINE 10MG 30 F.C. TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ALFACURE PHARMACEUTICALS", "price_egp": 63.0, "pack_count": 30, "unit_price": 2.1, "strength_mg": 10.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "CETRAK 10 MG 20 TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "PHARCO", "price_egp": 68.0, "pack_count": 20, "unit_price": 3.4, "strength_mg": 10.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "HISTAZINE-1 10 MG 20 TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "AMRIYA", "price_egp": 68.0, "pack_count": 20, "unit_price": 3.4, "strength_mg": 10.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ZYRTEC 10 MG 20 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "GLAXO SMITHKLINE", "price_egp": 100.0, "pack_count": 20, "unit_price": 5.0, "strength_mg": 10.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "CETRICHEW 10MG 20 CHEWABLE F.C. TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "AL ROWAD PHARMACEUTICAL INDUSTRIAL CO.", "price_egp": 15.0, "pack_count": null, "unit_price": null, "strength_mg": 10.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "HISTA CHEW 10 MG 20 CHEWABLE TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ARAB CAPS > ADVOCURE", "price_egp": 15.0, "pack_count": null, "unit_price": null, "strength_mg": 10.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "LERGFREE 5MG/5ML SYRUP 120ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "DEBEIKY", "price_egp": 9.0, "pack_count": null, "unit_price": null, "strength_mg": 5.0, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null }, { "trade_name": "EPIRIZINE 5MG/ML SYRUP 60 ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EIPICO", "price_egp": 19.0, "pack_count": null, "unit_price": null, "strength_mg": 5.0, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null } ], "condition_id": "post-nasal-drip" }, { "id": 1499, "generic": "Desloratadine", "line": 2, "is_adjunct": false, "form": "oral.solid", "strength_mg": 5.0, "adult_dose": "5 mg once daily (adults and adolescents 12 years and over)", "adult_duration": "While symptoms persist; review at 4 weeks and reconsider the diagnosis if there is no improvement", "dose_source": "eMC SmPC, Neoclarityn 5 mg film-coated tablets (Organon), sections 4.1 and 4.2", "rationale": "35 live products. Upper airway cough syndrome is driven by allergic or non-allergic rhinitis, and the SmPC indication is relief of the symptoms of allergic rhinitis. Once-daily, non-sedating, and the active metabolite of loratadine, so it is a cleaner choice than the cetirizine already listed for a patient who finds cetirizine sedating.", "cautions": [ "An antihistamine only helps the allergic form of upper airway cough syndrome. The intranasal steroid already in this row is the more effective component - do not substitute one for the other.", "Desloratadine is the same class as the cetirizine already listed - use one, not both.", "Use with caution in severe renal impairment; exposure is about 2.5 times higher.", "Caution where there is a personal or family history of seizures, particularly in young children.", "Contains lactose - avoid in galactose intolerance, total lactase deficiency or glucose-galactose malabsorption.", "Prefer to avoid in pregnancy; it passes into breast milk." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "Safety and efficacy of the 5 mg tablet in children under 12 years have not been established. An oral solution exists for younger children with its own age-banded dosing; efficacy data in 12-17 year olds are limited.", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [ { "trade_name": "DESLARGYL 5 MG 10 F.C.TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "KAHIRA", "price_egp": 3.5, "pack_count": 10, "unit_price": 0.35, "strength_mg": 5.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ORDESCA 5 MG 20 F.C.TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "RAMEDA", "price_egp": 20.0, "pack_count": 20, "unit_price": 1.0, "strength_mg": 5.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "STIMLORIC 5 MG 20 F.C.TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "SPIMACO MISR", "price_egp": 27.75, "pack_count": 20, "unit_price": 1.39, "strength_mg": 5.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "DELAREX 5 MG 20 F.C.TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "GLOBAL NAPI PHARMACEUTICALS", "price_egp": 48.0, "pack_count": 20, "unit_price": 2.4, "strength_mg": 5.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "HYGI-TADINE 5 MG 20 F.C.TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "DBK PHARMA > HYGINT PHARMACEUTICALS", "price_egp": 48.0, "pack_count": 20, "unit_price": 2.4, "strength_mg": 5.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "AERIUS 5 MG 20 F.C.TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "SCHERING PLOUGH > RAMCO", "price_egp": 118.0, "pack_count": 20, "unit_price": 5.9, "strength_mg": 5.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ALERGAWAY 5 MG 20 ORAL DISINTEG. TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EGPI > JASPER FOR PHARMACEUTICAL INDUSTRIES", "price_egp": 36.0, "pack_count": null, "unit_price": null, "strength_mg": 5.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "EMBANODEX 5 MG 20 ORALLY DISINTEGRATING TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EGPI > CHAMPIONS PHARMA (PAS)", "price_egp": 66.0, "pack_count": null, "unit_price": null, "strength_mg": 5.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ENDSTAMINE 2.5MG/5ML SYPUP 120 ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MASH PREMIERE", "price_egp": 7.0, "pack_count": null, "unit_price": null, "strength_mg": 2.5, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null }, { "trade_name": "SILISTARKISH 2.5MG/5ML SYP. 120 ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ALPAC > EGPI", "price_egp": 7.5, "pack_count": null, "unit_price": null, "strength_mg": 2.5, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null } ], "condition_id": "post-nasal-drip" } ] }