BETAMETHASONE DIPROPIONATE
Formtopical
Apply thin layer of 0.05% cream to tight prepuce twice daily for 4-8 weeks alongside gentle manual foreskin retraction x 4-8 weeks
Apply thin layer to narrow prepuce twice daily for 4-8 weeks with gentle retraction
EAU Guidelines on Paediatric Urology 2023 for the indication, with the product from Diprosone 0.05 % w/w Cream (betamethasone dipropionate) SmPC sections 2 and 4.2 (eMC product 6405): "Betamethasone dipropionate 0.064% w/w* (* equivalent to 0.05% betamethasone)" and "Adults and Children: Once to twice daily. In most cases a thin film of Diprosone Cream should be applied to cover the affected area twice daily." The SmPC carries no phimosis indication and states no 4 to 8 week course; those are from the EAU guideline, which is not held in this corpus.
Betamethasone is a potent topical corticosteroid applied to the tight foreskin to reduce local inflammation and improve tissue elasticity, helping gentle retraction succeed and potentially avoiding surgical circumcision.
- Physiological phimosis is normal in infants and young boys up to 3 years; do not force retraction.
- Avoid long-term uninterrupted topical steroid application to prepuce to prevent skin atrophy.
- Refer to urology for surgical circumcision if medical therapy fails or if recurrent balanitis/paraphimosis occurs.
| Egyptian brand | Manufacturer | Indicative price |
|---|---|---|
| DIPROSONE 0.05% CREAM 10 GM | MEMPHIS | 26.00 EGP |
| DIPROSONE 0.05% OINT. 10 GM | MEMPHIS | 26.00 EGP |
| DIPROSONE 0.05% CREAM 30 GM | MEMPHIS | 45.00 EGP |