{ "schema_version": 1, "kind": "condition", "id": "pertussis", "name": "Pertussis (Whooping Cough)", "category": "infectious", "sources": "CDC Pertussis Postexposure Prophylaxis and Treatment 2019 · CDC Recommended Antimicrobial Agents for the Treatment and Postexposure Prophylaxis of Pertussis, MMWR Recomm Rep 2005;54(RR-14):1-16, treatment table by age band - reprinted in full at Am Fam Physician 2006;74(2):333-336 (aafp.org/pubs/afp/issues/2006/0715/p333.html) · Egyptian National Drug Formulary - Antimicrobial 2023 (clarithromycin monograph)", "review_status": "reviewed", "verified_against": "CDC Pertussis Postexposure Prophylaxis and Treatment 2019 · CDC Recommended Antimicrobial Agents for the Treatment and Postexposure Prophylaxis of Pertussis, MMWR Recomm Rep 2005;54(RR-14):1-16, treatment table by age band - reprinted in full at Am Fam Physician 2006;74(2):333-336 (aafp.org/pubs/afp/issues/2006/0715/p333.html) · Egyptian National Drug Formulary - Antimicrobial 2023 (clarithromycin monograph) · Pertussis - disease-level clinical article (pertussis-clinical.txt) · MSF Essential Drugs 2024", "verified_date": "2026-08", "treatments": [ { "id": 1442, "generic": "Azithromycin", "line": 1, "is_adjunct": false, "form": "oral.solid", "strength_mg": 500.0, "adult_dose": "500 mg single dose on Day 1, then 250 mg once daily on Days 2-5", "adult_duration": "5 days", "dose_source": "CDC Recommended Antimicrobial Agents for the Treatment and Postexposure Prophylaxis of Pertussis, MMWR Recomm Rep 2005;54(RR-14):1-16, treatment table by age band - reprinted in full at Am Fam Physician 2006;74(2):333-336 (aafp.org/pubs/afp/issues/2006/0715/p333.html)", "rationale": "First-line macrolide therapy; preferred over erythromycin due to shorter duration and better compliance", "cautions": [ "Azithromycin is the macrolide of choice under 1 month. Erythromycin is associated with infantile hypertrophic pyloric stenosis and clarithromycin is not recommended in this age group - but the risk of untreated pertussis in a neonate outweighs the risk of IHPS.", "Early treatment (catarrhal phase) reduces disease severity; treatment in paroxysmal phase mainly prevents transmission.", "Monitor infants <6 weeks for infantile hypertrophic pyloric stenosis with macrolides.", "POST-EXPOSURE PROPHYLAXIS, article verbatim: \"PEP is recommended for household and close contacts, particularly those at high risk (infants, pregnant women, and immunocompromised individuals) and for healthcare personnel exposed to high-risk patients.\"", "The prophylactic regimen is this same regimen, and there is a deadline: \"PEP is most effective when initiated within 21 days of cough onset in the index case. The same macrolide regimens used for treatment (typically azithromycin) are recommended for prophylaxis.\"", "Being vaccinated does not exempt a contact: \"Regimens mirror treatment antibiotics (commonly azithromycin), and prior vaccination does not obviate the need for PEP.\"" ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "Two different regimens - check the age first. Under 6 months: 10 mg/kg once daily for 5 days, the same dose every day. 6 months and over: 10 mg/kg (max 500 mg) on day 1, then 5 mg/kg (max 250 mg) once daily on days 2-5. It is not a step-down under 6 months, and halving day 2 in a young infant under-treats the group most likely to die of this.", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": [ { "label": "Under 6 months", "age_min_months": 0, "age_max_months": 5, "dose_text": "10 mg/kg once daily for 5 days - the same dose every day, not a step-down" }, { "label": "6 months and over", "age_min_months": 6, "age_max_months": 216, "dose_text": "10 mg/kg (maximum 500 mg) on day 1, then 5 mg/kg (maximum 250 mg) once daily on days 2 to 5" } ], "peds_doses": null, "brands": [ { "trade_name": "AZATRIBACT 500MG 3 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "RIVA PHARMA S.A.E.", "price_egp": 13.5, "pack_count": 3, "unit_price": 4.5, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "GIGAZOCIN 500MG 5 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EGPI > PIONEER", "price_egp": 27.5, "pack_count": 5, "unit_price": 5.5, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "SYSTYMYCIN 500MG 3 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EGPI > NOVELL PHARMA", "price_egp": 21.5, "pack_count": 3, "unit_price": 7.17, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "AZITHROMASH 500 MG 3 F.C. TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MASH PREMIERE", "price_egp": 48.0, "pack_count": 3, "unit_price": 16.0, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "AZALIDE 500MG 3 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "UP PHARMA", "price_egp": 52.0, "pack_count": 3, "unit_price": 17.33, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "AZROLID 500 MG 6 F.C.TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "AMRIYA", "price_egp": 126.0, "pack_count": 6, "unit_price": 21.0, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ZERAMERATE 500 MG", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EGPI > GAMMA PHARMA", "price_egp": 28.5, "pack_count": null, "unit_price": null, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "DISTABCIN 500 MG 3 DISPERSIBLE TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EGPI", "price_egp": 43.5, "pack_count": null, "unit_price": null, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ZITHRODOSE 100MG/5ML SUSP. 15ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EL-OBOUR > AVERROES PHARMA-EGYPT", "price_egp": 12.0, "pack_count": null, "unit_price": null, "strength_mg": 100.0, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null }, { "trade_name": "ZITHROPHATE 200MG/5ML SUSP. 15ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ORGANO PHARMA > NOVELL PHARMA", "price_egp": 12.75, "pack_count": null, "unit_price": null, "strength_mg": 200.0, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null } ], "condition_id": "pertussis" }, { "id": 1444, "generic": "Referral & safety-netting (no drug therapy)", "line": 1, "is_adjunct": false, "form": null, "strength_mg": null, "adult_dose": null, "adult_duration": null, "dose_source": "Pertussis - disease-level clinical article (pertussis-clinical.txt)", "rationale": "Carries the referral criteria and warning signs for this condition, which apply whichever treatment is chosen.", "cautions": [ "RED FLAG - Infants younger than 6 months may need hospitalization, given the risk of apnea, hypoxia, dehydration, and pneumonia." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": null, "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [], "condition_id": "pertussis" }, { "id": 1443, "generic": "Clarithromycin", "line": 2, "is_adjunct": false, "form": "oral.solid", "strength_mg": 500.0, "adult_dose": "500 mg twice daily", "adult_duration": "7 days", "dose_source": "Egyptian National Drug Formulary - Antimicrobial 2023 (clarithromycin monograph)", "rationale": "Clarithromycin is a macrolide antibiotic that reduces Bordetella pertussis carriage and transmission; it serves as an alternative macrolide to azithromycin, which remains preferred in very young infants.", "cautions": [ "Not recommended under 1 month - use azithromycin.", "Caution in renal impairment and QT prolongation risk.", "Clarithromycin is an alternative macrolide option.", "GI side effects (nausea, abdominal pain) are common." ], "peds_mgkg_low": 7.5, "peds_mgkg_high": 7.5, "peds_max_mg": 500.0, "peds_basis": "dose", "peds_unit": "mg", "peds_note": "7.5 mg/kg twice daily for 7 days", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": [ { "weight_kg": 10, "low_mg": 75, "high_mg": 75, "capped": false }, { "weight_kg": 20, "low_mg": 150, "high_mg": 150, "capped": false }, { "weight_kg": 30, "low_mg": 225, "high_mg": 225, "capped": false }, { "weight_kg": 40, "low_mg": 300, "high_mg": 300, "capped": false } ], "brands": [ { "trade_name": "KAPIFECTIN 500 MG 14 F.C.TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EVA PHARMA", "price_egp": 37.0, "pack_count": 14, "unit_price": 2.64, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "LARITHROCIN 500MG 14 F.C. TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "GLOBAL NAPI PHARMACEUTICALS", "price_egp": 40.0, "pack_count": 14, "unit_price": 2.86, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "CAPRIVEXIN 500MG S.R. 14 F.C. TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "HORUS FOR PHARMACEUTICAL PRODUCTS", "price_egp": 58.0, "pack_count": 14, "unit_price": 4.14, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "CLARINOTION XL 500 MG 14 F.C.TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "RAMEDA > NOTION PHARMA", "price_egp": 83.0, "pack_count": 14, "unit_price": 5.93, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "KLARIMIX 500 MG 14 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "SIGMA > OCTOBER PHARMA", "price_egp": 144.0, "pack_count": 14, "unit_price": 10.29, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "INFECTOCURE 500 MG 14 F.C.TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EGPI", "price_egp": 156.0, "pack_count": 14, "unit_price": 11.14, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "KLACID 500 MG 14 F.C.TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "KAHIRA > ABBOTT LABORATORIES", "price_egp": 257.0, "pack_count": 14, "unit_price": 18.36, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "KLACID XL 500 MG 14 F.C.TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "KAHIRA > ABBOTT LABORATORIES", "price_egp": 299.0, "pack_count": 14, "unit_price": 21.36, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "KLARIMIX 125MG/5ML SUSP. 60ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "SIGMA", "price_egp": 36.0, "pack_count": null, "unit_price": null, "strength_mg": 125.0, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null }, { "trade_name": "KLARIMIX 250MG/5ML SUSP. 60ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "SIGMA", "price_egp": 52.0, "pack_count": null, "unit_price": null, "strength_mg": 250.0, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null } ], "condition_id": "pertussis" }, { "id": 1445, "generic": "Co-trimoxazole", "line": 2, "is_adjunct": false, "form": "oral.solid", "strength_mg": null, "adult_dose": "800 mg SMX/160 mg TMP twice daily", "adult_duration": "14 days", "dose_source": "MSF Essential Drugs 2024", "rationale": "Second-line antibiotic alternative for pertussis in patients who cannot tolerate macrolides.", "cautions": [ "Contraindicated in infants under 6 weeks due to risk of hyperbilirubinemia.", "Contraindicated in severe renal or hepatic impairment or known hypersensitivity to sulfonamides. MSF Essential Drugs 2024, CO-TRIMOXAZOLE = SULFAMETHOXAZOLE (SMX)/TRIMETHOPRIM (TMP) oral monograph (pages 103-105), Contra-indications: do not give it where renal or hepatic impairment is severe, or where there is a history of hypersensitivity to a sulfonamide." ], "peds_mgkg_low": 4.0, "peds_mgkg_high": 4.0, "peds_max_mg": 160.0, "peds_basis": "dose", "peds_unit": "mg", "peds_note": "Child 6 weeks and over: 20 mg SMX/4 mg TMP/kg (max 800 mg SMX/160 mg TMP) twice daily for 14 days", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": [ { "weight_kg": 10, "low_mg": 40, "high_mg": 40, "capped": false }, { "weight_kg": 20, "low_mg": 80, "high_mg": 80, "capped": false }, { "weight_kg": 30, "low_mg": 120, "high_mg": 120, "capped": false }, { "weight_kg": 40, "low_mg": 160, "high_mg": 160, "capped": false } ], "brands": [ { "trade_name": "CO-TRIMOXAZOLE 20 TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MUP", "price_egp": 5.0, "pack_count": 20, "unit_price": 0.25, "strength_mg": null, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "COTRIL 400/80MG 20 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EL NASR", "price_egp": 38.0, "pack_count": 20, "unit_price": 1.9, "strength_mg": 80.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "SEPTAZOLE FORTE 800/160MG 20 TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ALEXANDRIA", "price_egp": 56.0, "pack_count": 20, "unit_price": 2.8, "strength_mg": 160.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "SEPTRIN D.S 10 TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "GLAXO SMITHKLINE > ASPEN PHARMA TRADING LIMITED", "price_egp": 28.0, "pack_count": 10, "unit_price": 2.8, "strength_mg": null, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "SEPTAZOLE 400/80MG 20*10 TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ALEXANDRIA", "price_egp": 340.0, "pack_count": 10, "unit_price": 34.0, "strength_mg": 80.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "SUTRIM 400/80MG 20*10 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MEMPHIS", "price_egp": 340.0, "pack_count": 10, "unit_price": 34.0, "strength_mg": 80.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "CO-TRIMOXAZOLE 200/40MG SUSP. 120ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MUP", "price_egp": 6.0, "pack_count": null, "unit_price": null, "strength_mg": 40.0, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null }, { "trade_name": "SUTRIM 200/40MG SUSP. 100ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MEMPHIS", "price_egp": 18.5, "pack_count": null, "unit_price": null, "strength_mg": 40.0, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null } ], "condition_id": "pertussis" } ] }