{ "schema_version": 1, "kind": "condition", "id": "nausea", "name": "Nausea", "category": "acute", "sources": "Egyptian National Drug Formulary - git.pdf, Domperidone monograph (chapter PDF p36) · Egyptian National Drug Formulary - git.pdf, Metoclopramide monograph (chapter PDF p39)", "review_status": "reviewed", "verified_against": "Egyptian National Drug Formulary - git.pdf, Domperidone monograph (chapter PDF p36) · Egyptian National Drug Formulary - git.pdf, Metoclopramide monograph (chapter PDF p39)", "verified_date": "2026-08", "treatments": [ { "id": 1248, "generic": "Metoclopramide", "line": 1, "is_adjunct": false, "form": "injection", "strength_mg": null, "adult_dose": "10 mg orally, IV, or IM, repeated up to three times daily (maximum 30 mg or 0.5 mg/kg per day)", "adult_duration": "Maximum 5 days", "dose_source": "Egyptian National Drug Formulary - git.pdf, Metoclopramide monograph (chapter PDF p39)", "rationale": "First-line, widely available antiemetic covering the formulary's general 'symptomatic treatment of nausea and vomiting' indication, which fits this non-specific presentation directly.", "cautions": [ "Extrapyramidal reactions can occur (acute dystonia, especially in young women) - limit to 5 days for this reason.", "Avoid in Parkinson's disease and in known/suspected bowel obstruction or perforation.", "Cardiac symptoms accompanying nausea need urgent cardiac workup, not just an antiemetic.", "Severe dehydration or inability to keep fluids down needs IV rehydration, not oral therapy alone.", "RED FLAG - Chest pain accompanying nausea, signs of raised intracranial pressure (severe headache, neurological deficit), signs of bowel obstruction or peritonitis, or severe dehydration or inability to keep fluids down, especially in pregnancy." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "Ages 1-18 years, as a second-line agent: 0.1 to 0.15 mg/kg oral/IM/IV up to three times daily, maximum 0.5 mg/kg in 24 hours; safety and efficacy not established under 1 year.", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": [ { "label": "1 to 18 years", "age_min_months": 12, "age_max_months": 216, "dose_text": "Second line only: 0.1 to 0.15 mg/kg by mouth, IM or IV, up to three times daily, maximum 0.5 mg/kg in 24 hours. Not established under 1 year." } ], "peds_doses": null, "brands": [ { "trade_name": "AMETIC 10MG/2ML 3 AMP. FOR I.M./I.V. INJ.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EIMC > PHAROPHARMA", "price_egp": 3.75, "pack_count": null, "unit_price": null, "strength_mg": 10.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "PLEMAZOL 10MG/2ML 5 AMP.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "CID", "price_egp": 3.8, "pack_count": null, "unit_price": null, "strength_mg": 10.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "METOCLOPRAMIDE 10MG/2ML 5 AMP. FOR IV/IM INJ.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "SEDICO", "price_egp": 8.0, "pack_count": null, "unit_price": null, "strength_mg": 10.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "MECLOPRAM 10MG/2ML 5 I.M./I.V.AMP.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ALEXANDRIA", "price_egp": 40.0, "pack_count": null, "unit_price": null, "strength_mg": 10.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "PRIMPERAN 10MG/2ML 12 AMP.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "SANOFI", "price_egp": 60.0, "pack_count": null, "unit_price": null, "strength_mg": 10.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "SUNNYPYRAMID 10MG/2ML 50 AMP.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "SUNNY MEDICAL", "price_egp": 400.0, "pack_count": null, "unit_price": null, "strength_mg": 10.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null } ], "condition_id": "nausea" }, { "id": 1249, "generic": "Domperidone", "line": 2, "is_adjunct": false, "form": "oral.solid", "strength_mg": null, "adult_dose": "10 mg orally up to three times daily (maximum 30 mg per day)", "adult_duration": "Lowest effective dose for the shortest duration, maximum 1 week", "dose_source": "Egyptian National Drug Formulary - git.pdf, Domperidone monograph (chapter PDF p36)", "rationale": "Formulary indication is simply 'relief of the symptoms of nausea and vomiting', a direct match for this non-specific complaint, and it is a useful alternative to metoclopramide.", "cautions": [ "Taken by mouth, not rectally: the dose text reads '10 mg orally up to three times daily'.", "There is a QT-interval prolongation risk - avoid with other QT-prolonging drugs and in significant cardiac or electrolyte disease.", "Does not cross the blood-brain barrier well, so lower extrapyramidal risk than metoclopramide - a reasonable alternative when EPS is a concern.", "The maximum duration is one week per formulary; re-assess if symptoms persist." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "Not recommended in children under 12 years or in adolescents weighing less than 35 kg per this formulary.", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [ { "trade_name": "DOMPIDONE 10 MG 30 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ARAB DRUG COMPANY (ADCO)", "price_egp": 17.25, "pack_count": 30, "unit_price": 0.57, "strength_mg": 10.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "SYNCHROGIT 10MG 20 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "RAMEDA", "price_egp": 15.0, "pack_count": 20, "unit_price": 0.75, "strength_mg": 10.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "MOTINORM 10MG 30 TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "GLAXO SMITHKLINE", "price_egp": 28.25, "pack_count": 30, "unit_price": 0.94, "strength_mg": 10.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "GASTROMOTIL 10MG 20 F.C. TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EIPICO", "price_egp": 26.0, "pack_count": 20, "unit_price": 1.3, "strength_mg": 10.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "MOTILIUM 10MG 40 F.C.TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MINA PHARM > JANSSEN CILAG", "price_egp": 100.0, "pack_count": 40, "unit_price": 2.5, "strength_mg": 10.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "GASTRONORM 10MG 5 SACHET", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "SIGMA", "price_egp": 5.5, "pack_count": null, "unit_price": null, "strength_mg": 10.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "MOTIL FAST 10 MG 10 EFF. SACHETS", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "AMOUN", "price_egp": 26.0, "pack_count": null, "unit_price": null, "strength_mg": 10.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "DONARAX 10 MG 30 ORODISPERSIBLE TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "JEDCO INT. CO. FOR PHARMACEUTICALS > ARAX PHARM. IND.", "price_egp": 39.0, "pack_count": null, "unit_price": null, "strength_mg": 10.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "DOMPIDONE 100MG/100ML ORAL SUSP. 100ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ARAB DRUG COMPANY (ADCO)", "price_egp": 6.0, "pack_count": null, "unit_price": null, "strength_mg": 100.0, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null }, { "trade_name": "MOTILIUM 1MG/ML SUSP. 100ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MINA PHARM > JANSSEN CILAG", "price_egp": 15.75, "pack_count": null, "unit_price": null, "strength_mg": 1.0, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null } ], "condition_id": "nausea" } ] }