Motion Sickness

50-100 mg (1-2 tablets) taken 30-60 minutes before travel, then 50-100 mg every 4-6 hours. Maximum 400 mg (8 tablets) in 24 hours

(Label verbatim, and the 24-hour ceilings matter as much as the doses. "Children 6 to under 12 years: give ½ to 1 tablet every 6-8 hours" and "do not give more than 3 tablets in 24 hours, or as directed by a doctor". "Children 2 to under 6 years: give ½ tablet every 6-8 hours" and "do not give more than 1 ½ tablets in 24 hours, or as directed by a doctor". These are halves of the 50 mg tablet; the label gives no dose under 2 years.)

Dramamine Original 50 mg tablets, Directions (DailyMed SetID f9302a5a-295a-4501-9332-e3f5eb387362)

Antihistamine with anticholinergic activity that dampens vestibular signalling to the vomiting centre, the first-line agent for preventing and treating motion-sickness nausea.

Motion Sickness - disease-level clinical article (motion-sickness-clinical.txt)

Carries the referral criteria and warning signs for this condition, which apply whichever treatment is chosen.

25-50 mg (1-2 chewable tablets) once daily, taken one hour before travel starts

(12 years and over: 25-50 mg once daily, one hour before travel - the label dose is the same as for adults. Below 12 years the label gives no dose; ask a doctor.)

Bonine (meclizine hydrochloride) 25 mg chewable tablets, Directions (DailyMed SetID 0b2ea6b8-b342-4940-8922-898758fbeb31)

Antihistamine with the same vestibular-suppressing mechanism as dimenhydrinate, chosen instead when a longer-acting, less sedating option is preferred.

50 mg by mouth, up to three times a day, started before the journey. SmPC verbatim: "Adults 50 mg orally, which may be repeated up to three times a day." and "To prevent motion sickness Cyclizine Hydrochloride should be taken about one to two hours before departure." - For the journey only - repeated up to three times a day while travel continues, not taken between trips.

(From 6 years, halved. SmPC verbatim: "Children less than 6 years of age: Cyclizine Hydrochloride tablets are not recommended for children less than 6 years of age." "Children 6 to 12 years of age: 25 mg orally, which may be repeated up to three times a day." "Children over 12 years of age: 50 mg orally, which may be repeated up to three times a day.")

Valoid 50 mg Tablets SmPC sections 4.1, 4.2 and 4.4 (eMC product 15294)

The disease article names it and compares it with the drug already on the card, verbatim: "Cyclizine - First generation antihistamine available orally over the counter. It has shown similar efficacy to diphenhydramine, but with slightly less sedation and more direct action on the stomach in treating gastrointestinal symptoms." and "It is FDA approved for adults and children over 6 years old." The SmPC's indication list names motion sickness outright. Egypt registers cyclizine as EMETREX tablets, which are cyclizine with vitamin B6 rather than cyclizine alone, and as plain cyclizine ampoules - so the oral product a patient will actually be handed is a combination, and the dose above is the cyclizine content.

One patch behind one ear, applied in advance. Per the US label: apply one patch to the hairless skin behind one ear no less than 4 hours ahead of when the antiemetic effect is needed; one patch lasts up to 3 days. If treatment must continue past 3 days, take off the first patch and put a fresh one behind the other ear. Each patch delivers about 1 mg of scopolamine over its 3 days. The label is firm on handling: wear only one patch at a time, never cut it, and after applying it wash and dry the hands thoroughly, using soap and water. The disease article gives the same instruction in its own words - the patch goes on the mastoid area a minimum of 4 hours before travel and lasts 72 hours. - Up to three days per patch, then a fresh patch behind the other ear if the journey is longer. It is tied to the travel, not to a course.

Not a paediatric prescription, and the label is unusually specific about why. Safety and effectiveness have not been established in children, who are particularly prone to scopolamine's anticholinergic effects - including neurological and psychiatric reactions and a withdrawal syndrome on stopping it. Reported serious reactions in children include acute psychosis (disorientation, hallucinations), amblyopia, hyperthermia (with one fatal case), and dilated pupils. The disease article agrees and sets its own floor: it is not recommended under 12 years. A child with travel sickness uses one of the oral options on the card instead.

Scopolamine transdermal system (Rhodes Pharmaceuticals L.P.) US prescribing information, section 1 Indications and Usage, section 2 Dosage and Administration, section 4 Contraindications and section 8.4 Pediatric Use (DailyMed SetID ba5a1237-4d23-441a-808e-96b97045fbe2)

The disease article names scopolamine and ranks it top: the most effective agent available, a nonselective antimuscarinic that works by damping the signal reaching the vestibular nuclei, and it causes less sedation than the antihistamines. In the USA it comes as a prescription transdermal patch. The US label's indication section covers the same use in adults - preventing the nausea and vomiting of motion sickness. The card carried three oral antihistamines and nothing else, so the drug the article rates most effective was missing - and with it the advice the article repeats: these medicines work best started ahead of time, or at the very first hint of symptoms. Egypt registers no transdermal scopolamine product, so no brand or price can be shown here. The hyoscine butylbromide sold in Egypt is a different medicine - an oral and injectable antispasmodic for gut cramp, a different salt given by a different route, not this drug.

No Egyptian brand matched — prescribe by generic name.