{
  "schema_version": 1,
  "kind": "condition",
  "id": "malaise",
  "name": "Malaise (feeling generally unwell)",
  "category": "chronic",
  "sources": "ICPC-3 (WONCA International Classification of Primary Care, 3rd edition) class AS06 - condition scope only, no dose · No dose - referral pathway, no medicine given in primary care · Weakness and Fatigue - Clinical Methods - NCBI Bookshelf - https://www.ncbi.nlm.nih.gov/books/NBK326/",
  "review_status": "reviewed",
  "verified_against": "No dose - referral pathway, no medicine given in primary care",
  "verified_date": "2026-08",
  "treatments": [
    {
      "id": 1143,
      "generic": "No drug therapy in primary care (Recognition & Referral)",
      "line": 1,
      "is_adjunct": false,
      "form": null,
      "strength_mg": null,
      "adult_dose": "Malaise is a non-specific constitutional symptom that warrants a structured clinical evaluation to identify an underlying physical or psychological cause. Perform a detailed systems review, medication audit, and baseline laboratory investigations including complete blood count, ESR/CRP, fasting blood glucose, renal and liver function panels, serum electrolytes, TSH, and urinalysis. Screen systematically for red flags such as unexplained weight loss, night sweats, localized pain, lymphadenopathy, or severe mood disturbance, and avoid prescribing unguided vitamin or tonic supplements before completing diagnostic workup.",
      "adult_duration": "Refer",
      "dose_source": "No dose - referral pathway, no medicine given in primary care",
      "rationale": "Malaise is a non-specific constitutional symptom that warrants a structured clinical evaluation to identify an underlying physical or psychological cause. Perform a detailed systems review, medication audit, and baseline laboratory investigations including complete blood count, ESR/CRP, fasting blood glucose, renal and liver function panels, serum electrolytes, TSH, and urinalysis. Screen systematically for red flags such as unexplained weight loss, night sweats, localized pain, lymphadenopathy, or severe mood disturbance, and avoid prescribing unguided vitamin or tonic supplements before completing diagnostic workup.",
      "cautions": [
        "No medicine is prescribed for this in primary care - this entry is for recognition and referral. Anything given is decided by the service it is referred to.",
        "RED FLAG - Persistent malaise beyond 2 to 3 weeks, unintentional weight loss, night sweats, associated pallor, bleeding, or lymphadenopathy, or signs suggesting depression or thyroid disease."
      ],
      "peds_mgkg_low": null,
      "peds_mgkg_high": null,
      "peds_max_mg": null,
      "peds_basis": null,
      "peds_unit": null,
      "peds_note": "Children follow the same pathway: recognise and refer. No primary-care medicine is implied.",
      "peds_min_weight_kg": null,
      "peds_max_weight_kg": null,
      "peds_age_min_months": null,
      "peds_age_max_months": null,
      "peds_age_bands": null,
      "peds_doses": null,
      "brands": [],
      "condition_id": "malaise"
    }
  ]
}