{
  "schema_version": 1,
  "kind": "condition",
  "id": "leukopenia-neutropenia-referral",
  "name": "Leukopenia and Neutropenia Referral",
  "category": "chronic",
  "sources": "Egyptian National Drug Formulary - Antimicrobial 2023 · BSH Guideline on the Management of Neutropenia 2019",
  "review_status": "reviewed",
  "verified_against": "Egyptian National Drug Formulary - Antimicrobial 2023 · BSH Guideline on the Management of Neutropenia 2019",
  "verified_date": "2026-08",
  "treatments": [
    {
      "id": 1113,
      "generic": "Amoxicillin + clavulanic acid",
      "line": 1,
      "is_adjunct": false,
      "form": "oral.solid",
      "strength_mg": 1000.0,
      "adult_dose": "1 g (875/125 mg) twice daily",
      "adult_duration": "Until urgent hospital specialist evaluation",
      "dose_source": "Egyptian National Drug Formulary - Antimicrobial 2023 (amoxicillin and clavulanate monograph): \"Immediate release: 500 mg every 8 to 12 hours or 875 mg every 12 hours\", 875/125 mg tablet. The febrile-neutropenia indication is from the BSH Guideline on the Management of Neutropenia 2019, which is not held in this corpus.",
      "rationale": "Empirical broad-spectrum cover for mild outpatient febrile neutropenia while arranging emergency referral",
      "cautions": [
        "FEBRILE NEUTROPENIA IS A MEDICAL EMERGENCY (Absolute Neutrophil Count ANC <0.5 x 10^9/L with fever >=38.0C): Transfer immediately to hospital for IV broad-spectrum antibiotics.",
        "Identify drug-induced neutropenia (carbimazole, co-trimoxazole, NSAIDs, psychotropics) and stop suspected offending agent.",
        "Non-febrile mild/moderate neutropenia requires routine haematology investigation."
      ],
      "peds_mgkg_low": null,
      "peds_mgkg_high": null,
      "peds_max_mg": null,
      "peds_basis": null,
      "peds_unit": null,
      "peds_note": "Pediatric febrile neutropenia requires IMMEDIATE hospital admission for IV antibiotics; do not manage outpatient",
      "peds_min_weight_kg": null,
      "peds_max_weight_kg": null,
      "peds_age_min_months": null,
      "peds_age_max_months": null,
      "peds_age_bands": null,
      "peds_doses": null,
      "brands": [
        {
          "trade_name": "E-MOXCLAV 1G 10 F.C. TAB.",
          "scientific_name": null,
          "normalized_ingredient": null,
          "manufacturer": "EIPICO",
          "price_egp": 14.0,
          "pack_count": 10,
          "unit_price": 1.4,
          "strength_mg": 1000.0,
          "exact_strength": true,
          "exact_form": true,
          "discontinued": false,
          "also_contains": null
        },
        {
          "trade_name": "JULMENTIN 2X 1GM 15 TAB.",
          "scientific_name": null,
          "normalized_ingredient": null,
          "manufacturer": "JULPHAR",
          "price_egp": 57.5,
          "pack_count": 15,
          "unit_price": 3.83,
          "strength_mg": 1000.0,
          "exact_strength": true,
          "exact_form": true,
          "discontinued": false,
          "also_contains": null
        },
        {
          "trade_name": "DEXICLAVE 1 GM 10 F.C. TABS.",
          "scientific_name": null,
          "normalized_ingredient": null,
          "manufacturer": "RAMEDA > NOVELL PHARMA",
          "price_egp": 38.5,
          "pack_count": 10,
          "unit_price": 3.85,
          "strength_mg": 1000.0,
          "exact_strength": true,
          "exact_form": true,
          "discontinued": false,
          "also_contains": null
        },
        {
          "trade_name": "MACLAVEX 1 GM 14 F.C.TABS.",
          "scientific_name": null,
          "normalized_ingredient": null,
          "manufacturer": "MASH PREMIERE",
          "price_egp": 105.0,
          "pack_count": 14,
          "unit_price": 7.5,
          "strength_mg": 1000.0,
          "exact_strength": true,
          "exact_form": true,
          "discontinued": false,
          "also_contains": null
        },
        {
          "trade_name": "CLAVIMOX 1 GM 12 F.C.TABS.",
          "scientific_name": null,
          "normalized_ingredient": null,
          "manufacturer": "PHARCO",
          "price_egp": 130.0,
          "pack_count": 12,
          "unit_price": 10.83,
          "strength_mg": 1000.0,
          "exact_strength": true,
          "exact_form": true,
          "discontinued": false,
          "also_contains": null
        },
        {
          "trade_name": "MEGAMOX 1 GM 14 F.C. TABS.",
          "scientific_name": null,
          "normalized_ingredient": null,
          "manufacturer": "AL JAZEERA PHARMACEUTICAL > HIKMA PHARMA",
          "price_egp": 178.0,
          "pack_count": 14,
          "unit_price": 12.71,
          "strength_mg": 1000.0,
          "exact_strength": true,
          "exact_form": true,
          "discontinued": false,
          "also_contains": null
        },
        {
          "trade_name": "CLAVOCILLIN 1 GM 10 DISPERSIBLE TABS.",
          "scientific_name": null,
          "normalized_ingredient": null,
          "manufacturer": "RAMEDA > ORGANOPHARMA",
          "price_egp": 106.0,
          "pack_count": null,
          "unit_price": null,
          "strength_mg": 1000.0,
          "exact_strength": true,
          "exact_form": true,
          "discontinued": false,
          "also_contains": null
        },
        {
          "trade_name": "AUGMENTIN ADULTS 1GM/125MG 12 PWD. ORAL SUSP. SACHETS",
          "scientific_name": null,
          "normalized_ingredient": null,
          "manufacturer": "GLAXO SMITHKLINE",
          "price_egp": 169.0,
          "pack_count": null,
          "unit_price": null,
          "strength_mg": 1000.0,
          "exact_strength": true,
          "exact_form": true,
          "discontinued": false,
          "also_contains": null
        },
        {
          "trade_name": "LARYNCLAVE 125/31 PD. FOR ORAL SUSP. 70ML",
          "scientific_name": null,
          "normalized_ingredient": null,
          "manufacturer": "MISR > AL ROWAD PHARMACEUTICAL INDUSTRIAL CO.",
          "price_egp": 8.0,
          "pack_count": null,
          "unit_price": null,
          "strength_mg": null,
          "exact_strength": false,
          "exact_form": false,
          "discontinued": false,
          "also_contains": null
        },
        {
          "trade_name": "MEGACLAVOX 156MG/5ML PD. FOR SUSP. 60 ML",
          "scientific_name": null,
          "normalized_ingredient": null,
          "manufacturer": "CID",
          "price_egp": 8.0,
          "pack_count": null,
          "unit_price": null,
          "strength_mg": 156.0,
          "exact_strength": false,
          "exact_form": false,
          "discontinued": false,
          "also_contains": null
        }
      ],
      "condition_id": "leukopenia-neutropenia-referral"
    }
  ]
}