{ "schema_version": 1, "kind": "condition", "id": "keratosis-pilaris", "name": "Keratosis Pilaris", "category": "chronic", "sources": "Dampa E. The Effectiveness of Topical Keratolytics (Alpha Hydroxy Acids/Beta Hydroxy Acids/Urea) in Treating Keratosis Pilaris: A Review of the Literature. Cureus 2025;17(12):e100507 (https://pmc.ncbi.nlm.nih.gov/articles/PMC12860576/): \"In a randomized clinical study (split-side design) comparing 10% lactic acid to 5% salicylic acid applied twice daily for 12 weeks, both agents produced significant lesion reductions, with greater mean lesion reduction for lactic acid (66%) than salicylic acid (52%) by the end of treatment.\" · Dampa E. The Effectiveness of Topical Keratolytics (Alpha Hydroxy Acids/Beta Hydroxy Acids/Urea) in Treating Keratosis Pilaris: A Review of the Literature. Cureus 2025;17(12):e100507", "review_status": "reviewed", "verified_against": "Dampa E. The Effectiveness of Topical Keratolytics (Alpha Hydroxy Acids/Beta Hydroxy Acids/Urea) in Treating Keratosis Pilaris: A Review of the Literature. Cureus 2025;17(12):e100507 (https://pmc.ncbi.nlm.nih.gov/articles/PMC12860576/): \"In a randomized clinical study (split-side design) comparing 10% lactic acid to 5% salicylic acid applied twice daily for 12 weeks, both agents produced significant lesion reductions, with greater mean lesion reduction for lactic acid (66%) than salicylic acid (52%) by the end of treatment.\" · Dampa E. The Effectiveness of Topical Keratolytics (Alpha Hydroxy Acids/Beta Hydroxy Acids/Urea) in Treating Keratosis Pilaris: A Review of the Literature. Cureus 2025;17(12):e100507 · Keratosis Pilaris - disease-level clinical article (keratosis-pilaris-clinical.txt)", "verified_date": "2026-08", "treatments": [ { "id": 1091, "generic": "Urea", "line": 1, "is_adjunct": false, "form": "topical", "strength_mg": null, "adult_dose": "Urea 20% cream applied once daily to affected areas. Improvement in skin texture is typically visible within 1 to 4 weeks of once-daily application.", "adult_duration": "Continuous / maintenance as needed", "dose_source": "Dampa E. The Effectiveness of Topical Keratolytics (Alpha Hydroxy Acids/Beta Hydroxy Acids/Urea) in Treating Keratosis Pilaris: A Review of the Literature. Cureus 2025;17(12):e100507", "rationale": "The review reports 10-30% urea in common clinical use, 10% for mild disease and 20-30% for pronounced hyperkeratosis, with 20% once daily improving texture by one week and holding at four. Urea is both keratolytic and a humectant, which is why it suits a condition that is dry skin plus a plugged follicle.", "cautions": [ "NOTHING CURES IT. The review is explicit that treatment is cosmetic, has to continue, and does not alter the natural course - it commonly improves by itself with age.", "This is the entry's main use: it is extremely common and extremely over-treated. Antibiotics, strong steroids and acne treatments do not help it.", "Mild stinging is the usual side effect, and higher strengths sting more, especially on broken or eczematous skin.", "Scrubbing and picking make the redness worse, not better." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "Not established in paediatric patients; use under medical advice.", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [ { "trade_name": "URECARE 10% CREAM 30 GM", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EGPI", "price_egp": 23.0, "pack_count": null, "unit_price": null, "strength_mg": 30000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "UREMEL 100ML CREAM", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MELANO PHARMA FOR COSMETICS > MELANO PHARMA", "price_egp": 240.0, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "UREPAR 10% FOOT CREAM 200 ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EGYPTIAN CO. FOR COSMETICS (E.C.C.) > HAYAH LAB.", "price_egp": 264.0, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "UREPAR 10% BODY CREAM 200 ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EGYPTIAN CO. FOR COSMETICS (E.C.C.) > HAYAH LAB.", "price_egp": 357.0, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null } ], "condition_id": "keratosis-pilaris" }, { "id": 1092, "generic": "Lactic acid", "line": 2, "is_adjunct": false, "form": "topical", "strength_mg": null, "adult_dose": "Lactic acid 10% cream applied twice daily to affected areas for 12 weeks (produced 66% mean lesion reduction at 12 weeks versus 52% for salicylic acid 5%).", "adult_duration": "12 weeks, then ongoing maintenance as needed", "dose_source": "Dampa E. The Effectiveness of Topical Keratolytics (Alpha Hydroxy Acids/Beta Hydroxy Acids/Urea) in Treating Keratosis Pilaris: A Review of the Literature. Cureus 2025;17(12):e100507 (https://pmc.ncbi.nlm.nih.gov/articles/PMC12860576/): \"In a randomized clinical study (split-side design) comparing 10% lactic acid to 5% salicylic acid applied twice daily for 12 weeks, both agents produced significant lesion reductions, with greater mean lesion reduction for lactic acid (66%) than salicylic acid (52%) by the end of treatment.\"", "rationale": "An alpha hydroxy acid, and the better performer of the two keratolytics compared head to head in the review. Both showed improvement by week 4 continuing to week 12.", "cautions": [ "Same rule as urea: cosmetic, ongoing, and it does not change the natural course.", "Alpha hydroxy acids increase sun sensitivity - sun protection while using it.", "Avoid on broken, inflamed or freshly shaved skin.", "The one Egyptian topical product, CLEAR FACE 10%, has no route recorded in the register, so it shows a route warning. The pack itself says topical solution and the strength is the one the review studied." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "Many individuals experience partial improvement with age. Paediatric safety and specific concentration guidance are not established in this review.", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [ { "trade_name": "CLEAR FACE 10%W/W TOPICAL SOLUTION", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ALEXANDRIA > MILLENIUM PHARMA-EGYPT", "price_egp": 5.0, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": true, "exact_form": false, "discontinued": false, "also_contains": null } ], "condition_id": "keratosis-pilaris" }, { "id": 1093, "generic": "Salicylic acid", "line": 2, "is_adjunct": false, "form": "topical", "strength_mg": null, "adult_dose": "Apply salicylic acid 6% lotion topically to affected areas", "adult_duration": null, "dose_source": "Keratosis Pilaris - disease-level clinical article (keratosis-pilaris-clinical.txt)", "rationale": "Topical keratolytic agent used to exfoliate and improve skin texture in keratosis pilaris.", "cautions": [ "Strictly contraindicated in diabetic patients, peripheral vascular disease, or peripheral neuropathy due to risk of tissue necrosis and foot ulceration.", "Protect surrounding normal skin with petroleum jelly or zinc oxide ointment prior to application.", "Do not apply on broken, inflamed, or infected skin.", "Collodion is flammable - no smoking or naked flame until it has dried." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "Adults, children and the elderly: apply twice daily to the affected area.", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [ { "trade_name": "SALICYLIC ACID COLLODION 12% PAINT B.P.2001", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "UNIPHARMA CO. > UNIPHARMA", "price_egp": 3.0, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": true, "exact_form": false, "discontinued": false, "also_contains": null }, { "trade_name": "SALICYLIC ACID SOAP (WEISER) 45 GM", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "WEISER", "price_egp": 15.0, "pack_count": null, "unit_price": null, "strength_mg": 45000.0, "exact_strength": true, "exact_form": false, "discontinued": false, "also_contains": null } ], "condition_id": "keratosis-pilaris" } ] }