{ "schema_version": 1, "kind": "condition", "id": "jet-lag", "name": "Jet Lag (Desynchronosis)", "category": "acute", "sources": "AAFP - Can Melatonin Prevent or Treat Jet Lag? (Am Fam Physician 2002;66:2087) ยท Riedy SM, Williams SG. Jet Lag Disorder. In: CDC Yellow Book, 2026 edition: Health Information for International Travel [Internet]. Halsey ES, Angelo KM, Barnett ED, et al., editors. Atlanta (GA): Centers for Disease Control and Prevention (US); 2025 Apr 23. Published online April 23, 2025. NBK620865.", "review_status": "reviewed", "verified_against": "AAFP - Can Melatonin Prevent or Treat Jet Lag? (Am Fam Physician 2002;66:2087)", "verified_date": "2026-08", "treatments": [ { "id": 1080, "generic": "Melatonin", "line": 1, "is_adjunct": false, "form": "oral.solid", "strength_mg": 3.0, "adult_dose": "0.5-5 mg taken at the target bedtime at the destination (roughly 22:00 to midnight local time), starting on the day of arrival and continuing", "adult_duration": "2-5 days after arrival", "dose_source": "AAFP - Can Melatonin Prevent or Treat Jet Lag? (Am Fam Physician 2002;66:2087)", "rationale": "Worth using for flights crossing five or more time zones, and the benefit is larger going east than west - eastward travel asks the body clock to advance, which it does badly on its own. The dose is wide because the trials found little difference across it; 5 mg got people to sleep faster than the lower doses. What matters more than the number is the clock.", "cautions": [ "Timing is the whole treatment. Taken early in the day it makes jet lag worse - it causes daytime sleepiness and delays the body clock adapting.", "Case reports of harm in epilepsy and in patients taking warfarin. Avoid in both unless a specialist has agreed it.", "Do not drive or operate machinery for several hours after a dose.", "Melatonin is sold in Egypt as a supplement as well as a medicine, and content has been found not to match the label in some commercial products. Prefer a registered pharmaceutical pack." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "Not established for jet lag in children. Melatonin in childhood is a specialist prescription for sleep disorders in neurodevelopmental conditions, not something to give a healthy child after a flight.", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [ { "trade_name": "MELATONIN 3 MG 20 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "> HELIAN", "price_egp": 60.0, "pack_count": 20, "unit_price": 3.0, "strength_mg": 3.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "MELATONIN SHAHD PHARMA 3 MG 30 CAPSULES", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ORGANIX > SHAHD PHARMA", "price_egp": 120.0, "pack_count": 30, "unit_price": 4.0, "strength_mg": 3.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "DEVART MELATONIN 3 MG 30 TABS", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "DEVARTLAB > BIOERA", "price_egp": 125.0, "pack_count": 30, "unit_price": 4.17, "strength_mg": 3.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "AXIOM MELATONIN 3 MG 30 TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "> AXIOM", "price_egp": 150.0, "pack_count": 30, "unit_price": 5.0, "strength_mg": 3.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "VEE MELATONIN S.R. 3 MG 30 TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "VEEXIA PHARMACEUTICAL INDUSTRIES", "price_egp": 181.0, "pack_count": 30, "unit_price": 6.03, "strength_mg": 3.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "VEE MELATONIN 3 MG 10 TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "VEEXIA PHARMACEUTICAL INDUSTRIES", "price_egp": 88.0, "pack_count": 10, "unit_price": 8.8, "strength_mg": 3.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "VEE MELATONIN S.R. 3 MG 10 TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "VEEXIA PHARMACEUTICAL INDUSTRIES", "price_egp": 99.0, "pack_count": 10, "unit_price": 9.9, "strength_mg": 3.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "MELATONIN 3 MG 60 VEG. CAPS. (NOW)", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "NOW FOODS > SOFICOPHARM", "price_egp": 500.0, "pack_count": null, "unit_price": null, "strength_mg": 3.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "MELASNOZ 1MG/ML SYRUP 60 ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ORGANIX > PHARMA TECNOPROF", "price_egp": 60.0, "pack_count": null, "unit_price": null, "strength_mg": 1.0, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null }, { "trade_name": "MELATONIN 30 ML ORAL DROPS", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ORGANIX > EVOKA PHARMA", "price_egp": 78.0, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null } ], "condition_id": "jet-lag" } ] }