{ "schema_version": 1, "kind": "condition", "id": "influenza", "name": "Influenza (seasonal, outpatient)", "category": "infectious", "sources": "TAMIFLU (oseltamivir phosphate) US prescribing information, section 2.2 Recommended Dosage for Treatment of Influenza and Table 1 (DailyMed SetID ee3c9555-60f2-4f82-a760-11983c86e97b) · IDSA Guidelines for Influenza 2019 · MSF Essential Drugs 2024 - paracetamol (oral)", "review_status": "reviewed", "verified_against": "TAMIFLU (oseltamivir phosphate) US prescribing information, section 2.2 Recommended Dosage for Treatment of Influenza and Table 1 (DailyMed SetID ee3c9555-60f2-4f82-a760-11983c86e97b) · MSF Essential Drugs 2024 - paracetamol (oral)", "verified_date": "2026-08", "treatments": [ { "id": 1024, "generic": "Oseltamivir", "line": 1, "is_adjunct": false, "form": "oral.solid", "strength_mg": 75.0, "adult_dose": "75 mg twice daily orally (start within 48 hours of symptom onset for maximum benefit)", "adult_duration": "5 days", "dose_source": "TAMIFLU (oseltamivir phosphate) US prescribing information, section 2.2 Recommended Dosage for Treatment of Influenza and Table 1 (DailyMed SetID ee3c9555-60f2-4f82-a760-11983c86e97b)", "rationale": "First-line oral neuraminidase inhibitor antiviral registered and widely available in Egypt (Tamiflu, Epimiraflu) for high-risk or severe outpatient influenza", "cautions": [ "Start as early as possible, ideally within 48 hours of symptom onset; clinical benefit decreases significantly when started after 48h in uncomplicated low-risk cases.", "May cause nausea and vomiting; administration with food improves tolerability.", "Adjust dose in renal impairment (reduce dose if CrCl <60 mL/min).", "Contraindicated in patients with known serious hypersensitivity to oseltamivir.", "Monitor for neuropsychiatric events (confusion, abnormal behavior), particularly in pediatric patients." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "Infants 2 weeks to <1 year: 3 mg/kg/dose twice daily for 5 days. Children 1-12 years dosed by weight twice daily for 5 days: 15 kg or less: 30 mg; 15.1-23 kg: 45 mg; 23.1-40 kg: 60 mg; 40.1 kg or more: 75 mg.", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": [ { "label": "2 weeks to under 1 year", "age_min_months": 0, "age_max_months": 11, "dose_text": "3 mg/kg per dose twice daily for 5 days, from 2 weeks of age" }, { "label": "1 to 12 years", "age_min_months": 12, "age_max_months": 155, "dose_text": "Twice daily for 5 days by weight: 15 kg or less, 30 mg; 15.1 to 23 kg, 45 mg; 23.1 to 40 kg, 60 mg; 40.1 kg or more, 75 mg" } ], "peds_doses": null, "brands": [ { "trade_name": "TAMINIL-N 75 MG 10 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EL NILE.", "price_egp": 200.0, "pack_count": 10, "unit_price": 20.0, "strength_mg": 75.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "EPIMIRAFLU 75 MG 10 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EIPICO", "price_egp": 202.0, "pack_count": 10, "unit_price": 20.2, "strength_mg": 75.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "TAMILAVIR 75 MG 10 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EVA PHARMA", "price_egp": 242.0, "pack_count": 10, "unit_price": 24.2, "strength_mg": 75.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "OSELTAMIVIR 75 MG 10 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ARAB CAPS > ACDIMA INTERNATIONAL TRADING", "price_egp": 288.0, "pack_count": 10, "unit_price": 28.8, "strength_mg": 75.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "TAMIFLU 75MG 10 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "F.HOFFMAN LA ROCHE", "price_egp": 345.0, "pack_count": 10, "unit_price": 34.5, "strength_mg": 75.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "TAMINIL-N 12MG/ML SUSP. 30 ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EL NILE.", "price_egp": 123.5, "pack_count": null, "unit_price": null, "strength_mg": 12.0, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null }, { "trade_name": "TAMINIL-N 12MG/ML SUSP. 60 ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EL NILE.", "price_egp": 238.0, "pack_count": null, "unit_price": null, "strength_mg": 12.0, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null } ], "condition_id": "influenza" }, { "id": 1025, "generic": "Paracetamol", "line": 1, "is_adjunct": true, "form": "oral.solid", "strength_mg": 500.0, "adult_dose": "500-1000 mg three or four times a day PRN for fever, headache, and myalgia (max 4000 mg/day)", "adult_duration": "According to clinical response", "dose_source": "MSF Essential Drugs 2024 - paracetamol (oral)", "rationale": "Analgesic and antipyretic added to rest and fluids for symptomatic relief of fever, headache, and myalgia in influenza; it does not shorten the illness, and aspirin should be avoided in children because of Reye syndrome risk.", "cautions": [ "Avoid aspirin (acetylsalicylic acid) in children and adolescents with influenza due to the risk of Reye syndrome.", "Do not exceed maximum daily dose (4 g/day in adults) to avoid liver toxicity.", "500 mg is the per-dose ceiling used here for a child. 1000 mg is the adult dose and does not belong in a weight calculation - the daily 60 mg/kg limit is the one that binds first in any case.", "Administer with caution to patients with hepatic impairment." ], "peds_mgkg_low": 10.0, "peds_mgkg_high": 15.0, "peds_max_mg": 500.0, "peds_basis": "dose", "peds_unit": "mg", "peds_note": "Every 4-6 hours PRN (max 60 mg/kg/day or 4000 mg/day) Under 1 month: 10 mg/kg 3 or 4 times daily, maximum 40 mg/kg/day (MSF Essential Drugs 2024).", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": [ { "weight_kg": 10, "low_mg": 100, "high_mg": 150, "capped": false }, { "weight_kg": 20, "low_mg": 200, "high_mg": 300, "capped": false }, { "weight_kg": 30, "low_mg": 300, "high_mg": 450, "capped": false }, { "weight_kg": 40, "low_mg": 400, "high_mg": 500, "capped": true } ], "brands": [ { "trade_name": "FEBRIMOL 500 MG 20 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "PHARCO", "price_egp": 3.5, "pack_count": 20, "unit_price": 0.17, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "CETAMOL 500 MG 20 TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MEMPHIS", "price_egp": 8.0, "pack_count": 20, "unit_price": 0.4, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "PARACETAMOL-MUP 500MG B.P. 20 TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MUP", "price_egp": 13.0, "pack_count": 20, "unit_price": 0.65, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "CETAL 500 MG 20 TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EIPICO", "price_egp": 24.0, "pack_count": 20, "unit_price": 1.2, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ARKADOLOW 500 MG 30 F.C. TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "UTOPIA", "price_egp": 42.0, "pack_count": 30, "unit_price": 1.4, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "PARAMOL 500MG 20 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MISR", "price_egp": 38.0, "pack_count": 20, "unit_price": 1.9, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ADOL 500MG 24 CAPLETS", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "JULPHAR", "price_egp": 32.0, "pack_count": null, "unit_price": null, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "AUGICETAMIDE 500 MG 20 SACHETS", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "AUG PHARMA", "price_egp": 50.0, "pack_count": null, "unit_price": null, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "FEBRIMOL ORAL DROPS 20 ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "PHARCO", "price_egp": 4.0, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null }, { "trade_name": "THERA-LO 3.2G/100ML ORAL SUSP. 100 ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "PHAROPHARMA", "price_egp": 5.0, "pack_count": null, "unit_price": null, "strength_mg": 3200.0, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null } ], "condition_id": "influenza" } ] }