{ "schema_version": 1, "kind": "condition", "id": "ichthyosis-vulgaris", "name": "Ichthyosis Vulgaris", "category": "chronic", "sources": "Jaffar H, Shakir Z, Kumar G, Ali IF. Ichthyosis Vulgaris: An Updated Review. Skin Health and Disease 2022 · No labelled dose - emollient applied liberally and as often as needed, to effect", "review_status": "reviewed", "verified_against": "No labelled dose - emollient applied liberally and as often as needed, to effect · Jaffar H, Shakir Z, Kumar G, Ali IF. Ichthyosis Vulgaris: An Updated Review. Skin Health and Disease 2022 · Hereditary and Acquired Ichthyosis Vulgaris - disease-level clinical article (ichthyosis-vulgaris-clinical.txt)", "verified_date": "2026-08", "treatments": [ { "id": 991, "generic": "Liquid paraffin", "line": 1, "is_adjunct": false, "form": "topical", "strength_mg": null, "adult_dose": "Apply a bland emollient (liquid paraffin-based cream or ointment) liberally and frequently, at least 2-3 times daily, to all skin - not only the visibly scaly areas", "adult_duration": "Long-term continuous maintenance - this is a lifelong condition, not a flare that resolves", "dose_source": "No labelled dose - emollient applied liberally and as often as needed, to effect", "rationale": "Ichthyosis vulgaris is a lifelong inherited defect of skin desquamation, routinely dismissed and under-treated as ordinary dry skin. Regular, generous emollient is the foundation of care and needs to be more frequent and more sustained than for simple xerosis. This is the same emollient base used in the atopic-eczema-adult and infantile-seborrhoeic-dermatitis entries; it does not replace either - a patient can have ichthyosis vulgaris alongside eczema or cradle cap and needs both addressed.", "cautions": [ "Continue emollient use even when the skin looks clear - this is a lifelong barrier defect, not a flare that resolves and stays resolved.", "Apply emollient 15-30 minutes before or after the urea keratolytic below, not at the same time as it.", "Warn about fire hazard when fabric contacts paraffin-based products.", "Worsens in low humidity and cold, dry weather - increase application frequency in winter." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "Safe and appropriate from infancy; use a fragrance-free emollient and apply after bathing while the skin is still slightly damp to lock in moisture", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [ { "trade_name": "ADCOCARE CREAM 20 GM", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ARAB DRUG COMPANY (ADCO)", "price_egp": 12.0, "pack_count": null, "unit_price": null, "strength_mg": 20000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": "glyceryl monostearate, propylene glycol, urea" }, { "trade_name": "DERMOLAN CREAM 50 GM", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "HI-CARE > EMICO PHARMA", "price_egp": 19.0, "pack_count": null, "unit_price": null, "strength_mg": 50000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": "allantoin, glycerol, glycolic acid, panthenol, salicylic acid, urea, vitamin c, zinc oxide" }, { "trade_name": "ADCOCARE CREAM 40 GM", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ARAB DRUG COMPANY (ADCO)", "price_egp": 21.75, "pack_count": null, "unit_price": null, "strength_mg": 40000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": "glyceryl monostearate, propylene glycol, urea" }, { "trade_name": "CARE MIX PLUS HAIR CREAM 50 GM", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "VITA PHARM > CARE MIX", "price_egp": 29.5, "pack_count": null, "unit_price": null, "strength_mg": 50000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": "cetostearyl alcohol, lanolin, panthenol, wheat protein, white soft paraffin" }, { "trade_name": "PROPOLIS CREAM 15 ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "LUNA FOR PERFUMES AND COSMETICS > TECHNOMED GROUP", "price_egp": 30.0, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": "cera alba, glycerin, propolis" }, { "trade_name": "PROPOLIS CREAM 30 ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "LUNA FOR PERFUMES AND COSMETICS > TECHNOMED GROUP", "price_egp": 55.0, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": "cera alba, glycerin, propolis" }, { "trade_name": "HEALTHPOINT NAPPY CREAM 100 GM", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "HEALTHPOINT LTD. > PAXTON", "price_egp": 70.0, "pack_count": null, "unit_price": null, "strength_mg": 100000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": "benzyl alcohol, cetearyl alcohol, glyceryl stearate, lanolin, peg-100 s, water, zinc oxide" }, { "trade_name": "HERCUL WHITENING CREAM 60 GM", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "LEADER FOR COSMETICS > JUNIER PHARMA", "price_egp": 74.75, "pack_count": null, "unit_price": null, "strength_mg": 60000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": "alpha arbutin, diemthicone, glycerin, licorice ext, octyl methoxy, titanium dioxide, vit.c" } ], "condition_id": "ichthyosis-vulgaris" }, { "id": 993, "generic": "Referral & safety-netting (no drug therapy)", "line": 1, "is_adjunct": false, "form": null, "strength_mg": null, "adult_dose": null, "adult_duration": null, "dose_source": "Hereditary and Acquired Ichthyosis Vulgaris - disease-level clinical article (ichthyosis-vulgaris-clinical.txt)", "rationale": "Carries the referral criteria and warning signs for this condition, which apply whichever treatment is chosen.", "cautions": [ "RED FLAG - Acquired ichthyosis (new onset, not lifelong since childhood) can be a paraneoplastic or systemic-disease marker - Hodgkin lymphoma, multiple myeloma, cutaneous T-cell lymphoma, SLE, HIV, or malabsorptive conditions (celiac/Crohn's) - and needs investigation of the underlying cause rather than emollient therapy alone." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": null, "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [], "condition_id": "ichthyosis-vulgaris" }, { "id": 992, "generic": "Urea", "line": 2, "is_adjunct": true, "form": "topical", "strength_mg": null, "adult_dose": "Apply a 10% urea-based cream once or twice daily to scaly areas, in addition to the plain emollient above", "adult_duration": "Long-term, adjusted to scaling severity; reassess after 4-6 weeks", "dose_source": "Jaffar H, Shakir Z, Kumar G, Ali IF. Ichthyosis Vulgaris: An Updated Review. Skin Health and Disease 2022", "rationale": "This review reports that a urea-based emulsion containing 10% urea reduced dryness, roughness, and pruritus more than a plain glycerol-based emollient in ichthyosis vulgaris, applied twice daily, and was cosmetically acceptable. This is a distinct mechanism from the seborrhoeic-dermatitis entry, which treats a yeast-driven, non-scaling condition with antifungal and steroid rather than a keratolytic - the two entries are not interchangeable and a patient can need either or, less commonly, both.", "cautions": [ "Can cause transient stinging, particularly on cracked or fissured skin - start at lower frequency and build up as tolerated.", "Avoid on broken, weeping, or actively inflamed skin.", "This is not the same treatment as the seborrhoeic-dermatitis or atopic-eczema-adult entries - do not substitute one for the other; check those entries separately if scale, redness, or itch looks different from plain ichthyotic scaling.", "Reassess if there is no improvement in scaling after 4-6 weeks of regular use." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "Can sting on broken or fissured skin; introduce cautiously in young children and avoid on eczematous or excoriated areas. Not established in infants under 1 year - use plain emollient alone at that age", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [ { "trade_name": "URECARE 10% CREAM 30 GM", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EGPI", "price_egp": 23.0, "pack_count": null, "unit_price": null, "strength_mg": 30000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "UREPAR 10% FOOT CREAM 200 ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EGYPTIAN CO. FOR COSMETICS (E.C.C.) > HAYAH LAB.", "price_egp": 264.0, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "UREPAR 10% BODY CREAM 200 ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EGYPTIAN CO. FOR COSMETICS (E.C.C.) > HAYAH LAB.", "price_egp": 357.0, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "UREMEL 100ML CREAM", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MELANO PHARMA FOR COSMETICS > MELANO PHARMA", "price_egp": 240.0, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null } ], "condition_id": "ichthyosis-vulgaris" } ] }