{ "schema_version": 1, "kind": "condition", "id": "hypertension", "name": "Hypertension (essential, adult)", "category": "chronic", "sources": "DailyMed Amlodipine Besylate Tablet Package Insert, SetID 8a5d3f8a-4933-4f96-a193-4a7b7a607371 · DailyMed Enalapril Maleate Tablet Package Insert, SetID 5c5ef9e5-9d32-47ab-9d8a-6b4507000d66 · DailyMed Hydrochlorothiazide Tablet Package Insert, SetID 6d5e12f4-8a4b-4b1a-89bc-993d56781200 · Egyptian National Drug Formulary - Cardiovascular 2024 (bisoprolol monograph) · Egyptian National Drug Formulary - Cardiovascular 2024 (losartan monograph) · WHO Guideline for Pharmacological Treatment of Hypertension 2021", "review_status": "reviewed", "verified_against": "DailyMed Amlodipine Besylate Tablet Package Insert, SetID 8a5d3f8a-4933-4f96-a193-4a7b7a607371 · DailyMed Enalapril Maleate Tablet Package Insert, SetID 5c5ef9e5-9d32-47ab-9d8a-6b4507000d66 · DailyMed Hydrochlorothiazide Tablet Package Insert, SetID 6d5e12f4-8a4b-4b1a-89bc-993d56781200 · Egyptian National Drug Formulary - Cardiovascular 2024 (bisoprolol monograph) · Egyptian National Drug Formulary - Cardiovascular 2024 (losartan monograph)", "verified_date": "2026-08", "treatments": [ { "id": 966, "generic": "Amlodipine", "line": 1, "is_adjunct": false, "form": "oral.solid", "strength_mg": 5.0, "adult_dose": "5 mg once daily, may increase to maximum 10 mg once daily", "adult_duration": "long-term", "dose_source": "DailyMed Amlodipine Besylate Tablet Package Insert, SetID 8a5d3f8a-4933-4f96-a193-4a7b7a607371", "rationale": "Dihydropyridine calcium-channel blocker that relaxes vascular smooth muscle to lower blood pressure; a first-line option for essential hypertension.", "cautions": [ "Ankle oedema is dose-related and common.", "Avoid in severe aortic stenosis.", "Caution in hepatic impairment." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "Not first-line in children; specialist referral", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [ { "trade_name": "CORONAVINE 5 MG 10 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "PHAROPHARMA", "price_egp": 6.0, "pack_count": 10, "unit_price": 0.6, "strength_mg": 5.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "WINDIPINE 5 MG 30 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "SANOFI", "price_egp": 21.0, "pack_count": 30, "unit_price": 0.7, "strength_mg": 5.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "VASOPINE 5 MG 30 TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ARAB DRUG COMPANY (ADCO)", "price_egp": 24.0, "pack_count": 30, "unit_price": 0.8, "strength_mg": 5.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "AMILO 5 MG 30 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ALFACURE PHARMACEUTICALS", "price_egp": 54.0, "pack_count": 30, "unit_price": 1.8, "strength_mg": 5.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "AMLODIPINE 5 MG 30 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "AMRIYA", "price_egp": 60.0, "pack_count": 30, "unit_price": 2.0, "strength_mg": 5.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "MYODURA 5 MG 30 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "GLOBAL NAPI PHARMACEUTICALS > WOCKHARDT", "price_egp": 69.0, "pack_count": 30, "unit_price": 2.3, "strength_mg": 5.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "NORVASC 5MG 10 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "PFIZER > VIATRIS EGYPT", "price_egp": 54.0, "pack_count": 10, "unit_price": 5.4, "strength_mg": 5.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "NORVASC 5MG 30 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "PFIZER > VIATRIS EGYPT", "price_egp": 162.0, "pack_count": 30, "unit_price": 5.4, "strength_mg": 5.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null } ], "condition_id": "hypertension" }, { "id": 967, "generic": "Enalapril", "line": 1, "is_adjunct": false, "form": "oral.solid", "strength_mg": 10.0, "adult_dose": "5 mg once daily initially, titrate to 10-20 mg once daily (maximum 40 mg daily)", "adult_duration": "long-term", "dose_source": "DailyMed Enalapril Maleate Tablet Package Insert, SetID 5c5ef9e5-9d32-47ab-9d8a-6b4507000d66", "rationale": "ACE inhibitor that lowers blood pressure by reducing angiotensin II formation and vasoconstriction; a first-line alternative to amlodipine, avoided in pregnancy and bilateral renal artery stenosis.", "cautions": [ "CONTRAINDICATED in pregnancy.", "Avoid in bilateral renal artery stenosis.", "Check creatinine and potassium 1-2 weeks after starting.", "Dry cough is a common reason for switching." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "Specialist use only in children", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [ { "trade_name": "PRES 10MG 30 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "GLOBAL NAPI PHARMACEUTICALS", "price_egp": 20.25, "pack_count": 30, "unit_price": 0.68, "strength_mg": 10.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "PRESSLIGHT 10 MG 10 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EL-OBOUR", "price_egp": 10.0, "pack_count": 10, "unit_price": 1.0, "strength_mg": 10.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "EZAPRIL 10 MG 30 TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MULTI-APEX", "price_egp": 54.0, "pack_count": 30, "unit_price": 1.8, "strength_mg": 10.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null } ], "condition_id": "hypertension" }, { "id": 970, "generic": "Losartan", "line": 1, "is_adjunct": false, "form": "oral.solid", "strength_mg": 50.0, "adult_dose": "25-50 mg once daily, titrated after several weeks to 100 mg/day in 1-2 divided doses", "adult_duration": "long-term", "dose_source": "Egyptian National Drug Formulary - Cardiovascular 2024 (losartan monograph)", "rationale": "WHO 2021 gives a strong, high-certainty recommendation naming ACE inhibitors and ARBs together as one of three first-line classes, and losartan is on the Egyptian EML 2025 under antihypertensive medicines. The commonest reason for switching is the ACE inhibitor cough, already listed as a caution on the enalapril row.", "cautions": [ "CONTRAINDICATED in pregnancy.", "Does not cause the dry cough - this is the switch when enalapril is not tolerated. Do not give both.", "Check creatinine and potassium 1-2 weeks after starting and after each increase.", "Avoid in bilateral renal artery stenosis; do not combine with aliskiren in diabetes or renal impairment.", "Start at 25 mg in patients over 75 and in hepatic impairment." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "Licensed for hypertension from 6 years, weight-banded: 20 to under 50 kg, 25 mg once daily, maximum 50 mg/day; 50 kg and over, 50 mg once daily, maximum 100 mg/day. Not recommended if creatinine clearance is below 30 mL/min/1.73 m2. Paediatric hypertension is a specialist referral.", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": [ { "label": "6 years and over", "age_min_months": 72, "age_max_months": 216, "dose_text": "By weight. 20 to under 50 kg: 25 mg once daily, maximum 50 mg a day. 50 kg and over: 50 mg once daily, maximum 100 mg a day. Not if creatinine clearance is below 30 mL/min/1.73 m2. Specialist referral." } ], "peds_doses": null, "brands": [ { "trade_name": "LOSAPOTT 50 MG 14 F.C. TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "PHAROPHARMA", "price_egp": 21.6, "pack_count": 14, "unit_price": 1.54, "strength_mg": 50.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "LOSTAPRESSIN 50 MG 21 F.C. TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "DELTA PHARMA", "price_egp": 33.0, "pack_count": 21, "unit_price": 1.57, "strength_mg": 50.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "AMOSAR 50MG 30 F.C. TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "AMOUN", "price_egp": 51.0, "pack_count": 30, "unit_price": 1.7, "strength_mg": 50.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "LOSARTAN-AMRIYA 50MG 10 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "AMRIYA", "price_egp": 21.6, "pack_count": 10, "unit_price": 2.16, "strength_mg": 50.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "LOSARMEPHA-50 MG 14 F.C. TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "SIGMA > ACINO", "price_egp": 32.4, "pack_count": 14, "unit_price": 2.31, "strength_mg": 50.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "LOZAPRESS 50MG 14 F.C. TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "SIGMA", "price_egp": 32.4, "pack_count": 14, "unit_price": 2.31, "strength_mg": 50.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "LOSAR 50MG 28 F.C. TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "UNIPHARMA", "price_egp": 82.0, "pack_count": 28, "unit_price": 2.93, "strength_mg": 50.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "COZAAR 50MG 14 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MERCK SHARP & DOHME", "price_egp": 74.5, "pack_count": 14, "unit_price": 5.32, "strength_mg": 50.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null } ], "condition_id": "hypertension" }, { "id": 968, "generic": "Hydrochlorothiazide", "line": 2, "is_adjunct": false, "form": "oral.solid", "strength_mg": 25.0, "adult_dose": "25 mg daily given as a single dose, may be increased to 50 mg daily", "adult_duration": "long-term", "dose_source": "DailyMed Hydrochlorothiazide Tablet Package Insert, SetID 6d5e12f4-8a4b-4b1a-89bc-993d56781200", "rationale": "Thiazide diuretic that lowers blood pressure by reducing sodium and water reabsorption in the distal tubule; added as a second-line agent when a single first-line drug does not achieve control.", "cautions": [ "Monitor potassium and sodium.", "May precipitate gout.", "Caution in diabetes - may raise blood glucose." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "Specialist use only in children", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [ { "trade_name": "HYDROZIDE 25 MG 30 SCORED TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EPCI", "price_egp": 8.0, "pack_count": null, "unit_price": null, "strength_mg": 25.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null } ], "condition_id": "hypertension" }, { "id": 969, "generic": "Bisoprolol", "line": 3, "is_adjunct": false, "form": "oral.solid", "strength_mg": 5.0, "adult_dose": "2.5-5 mg once daily, up to 10 mg", "adult_duration": "long-term", "dose_source": "Egyptian National Drug Formulary - Cardiovascular 2024 (bisoprolol monograph)", "rationale": "Cardioselective beta-blocker that lowers blood pressure and heart rate by blocking beta-1 adrenergic receptors; a third-line option when blood pressure remains uncontrolled on first- and second-line agents, avoided in asthma and high-grade heart block.", "cautions": [ "Avoid in asthma and in second/third-degree heart block.", "Do not stop abruptly - risk of rebound.", "May mask hypoglycaemia in diabetes." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "Not routinely used in children", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [ { "trade_name": "BISOPROL 5 MG 20 F.C. TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "BIOPHARM EGYPT", "price_egp": 9.0, "pack_count": 20, "unit_price": 0.45, "strength_mg": 5.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "CAPROL 5MG 30 F.C.TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "INTERNATIONAL DRUG AGENCY (IDI) > NOVELL PHARMA", "price_egp": 18.0, "pack_count": 30, "unit_price": 0.6, "strength_mg": 5.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "BISOBETA 5MG 20 F.C. TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MEMPHIS", "price_egp": 14.0, "pack_count": 20, "unit_price": 0.7, "strength_mg": 5.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "SOPROL 5MG 20 F.C.TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EVA PHARMA", "price_egp": 14.0, "pack_count": 20, "unit_price": 0.7, "strength_mg": 5.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "NORMOCARD 5 MG 30 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "PHARMA CURE", "price_egp": 54.0, "pack_count": 30, "unit_price": 1.8, "strength_mg": 5.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "BISOLOCK 5 MG 30 F.C.TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "PHARCO", "price_egp": 57.0, "pack_count": 30, "unit_price": 1.9, "strength_mg": 5.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "EGYPRO 5 MG 30 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EGPI > ABBOTT", "price_egp": 63.0, "pack_count": 30, "unit_price": 2.1, "strength_mg": 5.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "CONCOR 5 MG 30 F.C. TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "AMOUN > MERCK KGAA F.R.GERMANY", "price_egp": 72.0, "pack_count": 30, "unit_price": 2.4, "strength_mg": 5.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null } ], "condition_id": "hypertension" } ] }