{ "schema_version": 1, "kind": "condition", "id": "hyperkalaemia", "name": "Hyperkalaemia (mild to moderate)", "category": "acute", "sources": "KDIGO Clinical Practice Guideline for Acute Kidney Injury 2012 · Egyptian National Drug Formulary - Cardiovascular 2024 (furosemide monograph) · Calcium Resonium (calcium polystyrene sulfonate) SmPC sections 4.2-4.4 (eMC product 1439) · Hyperkalemia - StatPearls - NCBI Bookshelf (NBK470284) - disease-level clinical article", "review_status": "reviewed", "verified_against": "Calcium Resonium (calcium polystyrene sulfonate) SmPC sections 4.2-4.4 (eMC product 1439) · Egyptian National Drug Formulary - Cardiovascular 2024 (furosemide monograph) · Hyperkalemia - StatPearls - NCBI Bookshelf (NBK470284) - disease-level clinical article", "verified_date": "2026-08", "treatments": [ { "id": 961, "generic": "Calcium polystyrene sulphonate", "line": 1, "is_adjunct": false, "form": "oral.liquid", "strength_mg": 15000.0, "adult_dose": "15 g 3 to 4 times daily in water", "adult_duration": null, "dose_source": "Calcium Resonium (calcium polystyrene sulfonate) SmPC sections 4.2-4.4 (eMC product 1439)", "rationale": "Cation-exchange resin that binds potassium in the gut in exchange for calcium, lowering serum potassium by increasing faecal excretion; used for mild-to-moderate hyperkalaemia when a slower-acting oral measure is appropriate.", "cautions": [ "Avoid in obstructive bowel disease.", "Suspend it in water or syrup - never fruit juice. Fruit juice is loaded with potassium and undoes the whole point of giving it.", "It has caused bowel stenosis, ischaemia, necrosis and perforation, some of them fatal. If the patient becomes significantly constipated, stop until the bowels move again.", "Never alongside sorbitol - that combination is the one most tied to intestinal necrosis.", "Not if the potassium is already below 5 mmol/L, not in obstructive bowel disease, and never by mouth in a neonate.", "Children: 1 g/kg/day in divided doses for acute hyperkalaemia, 0.5 g/kg/day to maintain.", "There is a risk of intestinal necrosis and constipation." ], "peds_mgkg_low": 500.0, "peds_mgkg_high": 1000.0, "peds_max_mg": null, "peds_basis": "day", "peds_unit": "mg", "peds_note": "Give in divided doses; monitor electrolytes closely", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": [ { "weight_kg": 10, "low_mg": 5000, "high_mg": 10000, "capped": false }, { "weight_kg": 20, "low_mg": 10000, "high_mg": 20000, "capped": false }, { "weight_kg": 30, "low_mg": 15000, "high_mg": 30000, "capped": false }, { "weight_kg": 40, "low_mg": 20000, "high_mg": 40000, "capped": false } ], "brands": [ { "trade_name": "RENOSTRITE POWDER FOR ORAL/RECTAL USE 500 GM", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "IDI > MIRA INTERNATIONAL", "price_egp": 627.5, "pack_count": null, "unit_price": null, "strength_mg": 500000.0, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null }, { "trade_name": "SORBISTERIT POWDER 500 GM", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "FRESENIUS KABI > EGYPTIAN GROUP FOR IMPORT AND EXPORT", "price_egp": 867.0, "pack_count": null, "unit_price": null, "strength_mg": 500000.0, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null } ], "condition_id": "hyperkalaemia" }, { "id": 962, "generic": "Furosemide", "line": 2, "is_adjunct": true, "form": "injection", "strength_mg": 40.0, "adult_dose": "40 mg intravenously every 12 hours, or by continuous infusion", "adult_duration": null, "dose_source": "Hyperkalemia - StatPearls - NCBI Bookshelf (NBK470284) - disease-level clinical article", "rationale": "Loop diuretic that promotes renal potassium excretion, added alongside potassium-binding therapy in a volume-overloaded patient with preserved renal function; it does not replace urgent hospital referral if potassium is severely elevated or ECG changes are present.", "cautions": [ "These agents may be administered in nonoliguric, volume-overloaded patients but should not be used as monotherapy in symptomatic hyperkalemia.", "Severe hyperkalaemia (>6.5 mmol/L or ECG changes) requires urgent hospital referral.", "In euvolaemia or hypovolaemia with preserved renal function, isotonic saline is given as needed before the 40 mg intravenous dose.", "Monitor blood pressure and renal function." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "The cited article gives an adult intravenous regimen only and records no paediatric dose for hyperkalaemia; a child with hyperkalaemia needs urgent hospital assessment.", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [ { "trade_name": "FUROSEMIDE 40MG/4ML 3 AMP.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "SEDICO", "price_egp": 6.5, "pack_count": null, "unit_price": null, "strength_mg": 40.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "LASIPHAR 40MG/4ML I.M./I.V. 3 AMPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EIMC > PHAROPHARMA", "price_egp": 6.5, "pack_count": null, "unit_price": null, "strength_mg": 40.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "DIUSEX 40MG/4ML 5 AMP.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "GLOBAL NAPI PHARMACEUTICALS > AL DELTA PHARMACEUTICALS TRADING CO.", "price_egp": 13.5, "pack_count": null, "unit_price": null, "strength_mg": 40.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "LAFUREX 40MG/4ML 3 AMP.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "AMOUN", "price_egp": 13.5, "pack_count": null, "unit_price": null, "strength_mg": 40.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "FUROSEMIDE-ALEX 40MG 5 I.M. I.V. AMP.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ALEXANDRIA", "price_egp": 50.0, "pack_count": null, "unit_price": null, "strength_mg": 40.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null } ], "condition_id": "hyperkalaemia" } ] }