{ "schema_version": 1, "kind": "condition", "id": "hidradenitis-suppurativa", "name": "Hidradenitis suppurativa (Hurley stage I/II)", "category": "chronic", "sources": "European HS Guidelines (EHSF) · BAD Guidelines for Hidradenitis Suppurativa · Egyptian National Drug Formulary - Antimicrobial 2023 (doxycycline monograph)", "review_status": "reviewed", "verified_against": "European HS Guidelines (EHSF) · Egyptian National Drug Formulary - Antimicrobial 2023 (doxycycline monograph)", "verified_date": "2026-08", "treatments": [ { "id": 945, "generic": "Clindamycin", "line": 1, "is_adjunct": false, "form": "topical", "strength_mg": null, "adult_dose": "Apply 1% topical solution or lotion twice daily to affected axillary/inguinal lesions", "adult_duration": "12 weeks", "dose_source": "European HS Guidelines (EHSF)", "rationale": "Topical lincosamide antibiotic with anti-inflammatory as well as antibacterial activity, applied to affected axillary and inguinal lesions in early-stage hidradenitis suppurativa to reduce local bacterial load and inflammation.", "cautions": [ "There is a risk of pseudomembranous colitis even with topical application (rare); stop if severe diarrhea develops.", "Skin dryness and irritation can occur at the application site." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "Adolescents >=12 years: apply twice daily to affected regions", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [ { "trade_name": "CLINDACINE RAMEDA 1% TOPICAL GEL 20 GM", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "RAMEDA", "price_egp": 7.0, "pack_count": null, "unit_price": null, "strength_mg": 20000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "CLINOCID 1% TOPICAL CREAM 30 GM", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "CID", "price_egp": 7.0, "pack_count": null, "unit_price": null, "strength_mg": 30000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "CLINDASOL 1% TOPICAL GEL 20 GM", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "AMRIYA > EUROPEAN EGYPTIAN PHARM. IND.", "price_egp": 26.0, "pack_count": null, "unit_price": null, "strength_mg": 20000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null } ], "condition_id": "hidradenitis-suppurativa" }, { "id": 946, "generic": "Doxycycline", "line": 1, "is_adjunct": false, "form": "oral.solid", "strength_mg": 100.0, "adult_dose": "100 mg twice daily (or 100 mg once daily)", "adult_duration": "12 weeks", "dose_source": "Egyptian National Drug Formulary - Antimicrobial 2023 (doxycycline monograph)", "rationale": "Anti-inflammatory and immunomodulatory oral agent for widespread Hurley I/II lesions", "cautions": [ "Do not take immediately before lying down (esophagitis risk).", "Contraindicated in pregnancy.", "There is a photosensitivity risk, so wear sunscreen." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "Use under 8 years only for a severe or potentially life-threatening infection, or where no better alternative exists - the risk is permanent tooth discoloration and enamel hypoplasia during tooth development. Where it is justified: 2.2 mg/kg every 12 hours, maximum 100 mg per dose.", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [ { "trade_name": "FARCODOXIN 100MG 10 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "PHARCO", "price_egp": 11.0, "pack_count": 10, "unit_price": 1.1, "strength_mg": 100.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "DOXY M.R.100 MG 10 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ADWIA", "price_egp": 12.0, "pack_count": 10, "unit_price": 1.2, "strength_mg": 100.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "GRANUDOXY 100MG 10 F.C. TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "GLOBAL NAPI PHARMACEUTICALS > PIERRE FRANCE", "price_egp": 12.0, "pack_count": 10, "unit_price": 1.2, "strength_mg": 100.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "DOXYDOX 100 MG 10 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EIPICO", "price_egp": 23.0, "pack_count": 10, "unit_price": 2.3, "strength_mg": 100.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "DOXYMYCIN 100 MG 10 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EL NILE.", "price_egp": 30.0, "pack_count": 10, "unit_price": 3.0, "strength_mg": 100.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "TABOCINE 100MG 10 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "TABUK PHARMACEUTICAL MANUFACTURING COMPANY > TABUK PHARMA", "price_egp": 46.0, "pack_count": 10, "unit_price": 4.6, "strength_mg": 100.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "VIBRAMYCIN 100MG 10 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "PFIZER", "price_egp": 65.0, "pack_count": 10, "unit_price": 6.5, "strength_mg": 100.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null } ], "condition_id": "hidradenitis-suppurativa" }, { "id": 947, "generic": "Rifampicin", "line": 2, "is_adjunct": true, "form": "oral.solid", "strength_mg": 300.0, "adult_dose": "300 mg twice daily combined with oral Clindamycin 300 mg twice daily", "adult_duration": "10-12 weeks", "dose_source": "European HS Guidelines (EHSF)", "rationale": "Combination therapy reserved for refractory Hurley II disease under specialist dermatology supervision", "cautions": [ "Rifampicin causes orange-red discoloration of body fluids (urine, sweat, tears, contact lenses).", "Rifampicin is a potent CYP450 enzyme inducer; it renders oral contraceptives INEFFECTIVE (must use barrier contraception).", "There is a hepatotoxicity risk, so monitor LFTs." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "Specialist pediatric dermatology referral required", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [ { "trade_name": "RIFAMPIN 300MG 10 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ARAB CAPS", "price_egp": 8.0, "pack_count": 10, "unit_price": 0.8, "strength_mg": 300.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "RIFABIOTIC 300 MG 8 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "CID", "price_egp": 8.0, "pack_count": 8, "unit_price": 1.0, "strength_mg": 300.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "RIFAMPICIN 300MG 8 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EL NASR", "price_egp": 9.5, "pack_count": 8, "unit_price": 1.19, "strength_mg": 300.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "RIFAMPIN 300MG 8 CAPS (MISR)", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MISR", "price_egp": 9.5, "pack_count": 8, "unit_price": 1.19, "strength_mg": 300.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "RIMACTANE 300MG 8 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "NOVARTIS", "price_egp": 10.1, "pack_count": 8, "unit_price": 1.26, "strength_mg": 300.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "RIFAMPIN 300MG 10 CAPS. (DEBEIKY)", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "DEBEIKY", "price_egp": 38.5, "pack_count": 10, "unit_price": 3.85, "strength_mg": 300.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "RIFACTINE 300 MG 8 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MUP", "price_egp": 31.0, "pack_count": 8, "unit_price": 3.88, "strength_mg": 300.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "RIFAMOX 100MG/5ML 30GM SUSP.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EL NASR", "price_egp": 4.5, "pack_count": null, "unit_price": null, "strength_mg": 100.0, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null }, { "trade_name": "RIFAM 100MG/5ML 60ML SUSP.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "PHARCO", "price_egp": 7.0, "pack_count": null, "unit_price": null, "strength_mg": 100.0, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null } ], "condition_id": "hidradenitis-suppurativa" } ] }