{ "schema_version": 1, "kind": "condition", "id": "gastroenteritis-in-infants", "name": "Acute Gastroenteritis in Infants", "category": "infectious", "sources": "ESPGHAN/ESPID Evidence-Based Guidelines for Acute Gastroenteritis in Children 2014 for the indication, with the figures from Egyptian National Drug Formulary - GIT medicines 2025, ondansetron monograph (endf-git.txt): \"IV single dose: 0.15 mg/kg given immediately before chemotherapy (must not exceed 8 mg)\" and \"> 10 kg Up to 3 doses of 0.15 mg/kg IV every 4 hours 4 mg syrup or tablet every 12 hours\". The formulary states those figures for chemotherapy-induced vomiting; the gastroenteritis indication is the ESPGHAN guideline's, which is not held in this corpus. · WHO/UNICEF IMCI Guidelines 2014 · ESPGHAN/ESPID Evidence-Based Guidelines for Acute Gastroenteritis in Children 2014 · WHO. The treatment of diarrhoea: a manual for physicians and other senior health workers, 4th rev. Geneva: WHO; 2005 (IRIS 10665/43209), section 4.3.1 and Table 2", "review_status": "reviewed", "verified_against": "ESPGHAN/ESPID Evidence-Based Guidelines for Acute Gastroenteritis in Children 2014 for the indication, with the figures from Egyptian National Drug Formulary - GIT medicines 2025, ondansetron monograph (endf-git.txt): \"IV single dose: 0.15 mg/kg given immediately before chemotherapy (must not exceed 8 mg)\" and \"> 10 kg Up to 3 doses of 0.15 mg/kg IV every 4 hours 4 mg syrup or tablet every 12 hours\". The formulary states those figures for chemotherapy-induced vomiting; the gastroenteritis indication is the ESPGHAN guideline's, which is not held in this corpus. · WHO/UNICEF IMCI Guidelines 2014 · ESPGHAN/ESPID Evidence-Based Guidelines for Acute Gastroenteritis in Children 2014 · WHO. The treatment of diarrhoea: a manual for physicians and other senior health workers, 4th rev. Geneva: WHO; 2005 (IRIS 10665/43209), section 4.3.1 and Table 2 · Acute Gastroenteritis in Infants - disease-level clinical article (gastroenteritis-in-infants-clinical.txt)", "verified_date": "2026-08", "treatments": [ { "id": 810, "generic": "ORS", "line": 1, "is_adjunct": false, "form": "oral.liquid", "strength_mg": null, "adult_dose": "Not applicable - pediatric entry", "adult_duration": "3-5 days", "dose_source": "WHO. The treatment of diarrhoea: a manual for physicians and other senior health workers, 4th rev. Geneva: WHO; 2005 (IRIS 10665/43209), section 4.3.1 and Table 2", "rationale": "Glucose-electrolyte solution that uses the co-transport of sodium and glucose across the intact gut mucosa to replace fluid and electrolyte losses from diarrhoea, preventing dehydration and reducing the need for hospitalisation without requiring IV access.", "cautions": [ "CORNERSTONE OF MANAGEMENT: Reduced osmolarity ORS prevents hospitalization.", "DO NOT stop breastfeeding or dilute infant formula.", "RED FLAGS: Lethargy, sunken eyes, skin pinch >2 sec, persistent vomiting, blood in stool — refer urgently for IV fluids." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "Some dehydration: give the infant's weight in kg x 75 mL of ORS solution over the first 4 hours, plus 10 mL/kg for each further loose stool. Continue breastfeeding throughout. Reassess fully at 4 hours.", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [ { "trade_name": "GLUCOHYDRAN 10 SACHET.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ARAB DRUG COMPANY (ADCO)", "price_egp": 1.75, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "REHYDRAN N 10 SACHET", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "CID", "price_egp": 4.5, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "REHYDRO ZINC 10 SACHETS", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "CID", "price_egp": 7.0, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ORS 20 SACHETS", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "PHAROPHARMA", "price_egp": 40.0, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ELECTRO MASH SYRUP 200 ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MASH PREMIERE", "price_egp": 60.0, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "FLEXOLYTE ORAL REHYDRATION SOL. 240 ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "KEMPETRO FOR CHEMICAL INDUSTRIES", "price_egp": 65.0, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "HERO ORS 200 ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "HERO > HERO MEA TRADING", "price_egp": 120.0, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "SANSO ORS SYRUP 140 ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "AUG PHARMA", "price_egp": 400.0, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null } ], "condition_id": "gastroenteritis-in-infants" }, { "id": 813, "generic": "Referral & safety-netting (no drug therapy)", "line": 1, "is_adjunct": false, "form": null, "strength_mg": null, "adult_dose": null, "adult_duration": null, "dose_source": "Acute Gastroenteritis in Infants - disease-level clinical article (gastroenteritis-in-infants-clinical.txt)", "rationale": "Carries the referral criteria and warning signs for this condition, which apply whichever treatment is chosen.", "cautions": [ "RED FLAG - Hospitalization and IV fluids are indicated for severe dehydration or intractable vomiting." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": null, "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [], "condition_id": "gastroenteritis-in-infants" }, { "id": 811, "generic": "Zinc sulfate", "line": 1, "is_adjunct": true, "form": "oral.liquid", "strength_mg": 10.0, "adult_dose": "Not applicable - pediatric entry", "adult_duration": "10-14 days", "dose_source": "WHO/UNICEF IMCI Guidelines 2014", "rationale": "WHO/UNICEF IMCI recommendation: zinc reduces duration and severity of infantile diarrhoea and prevents recurrence for 3 months", "cautions": [ "Complete the full course - 10 to 14 days per WHO - even after the diarrhoea stops.", "Egyptian products are zinc sulfate syrups, not the dispersible tablet the guideline describes. Give the stated milligram dose, measured from the strength printed on the bottle." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "Infants <6 months: 10 mg elemental zinc once daily; Infants >=6 months and children: 20 mg once daily for 10-14 days", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": [ { "label": "Under 6 months", "age_min_months": 0, "age_max_months": 5, "dose_text": "10 mg elemental zinc once daily" }, { "label": "6 months and over", "age_min_months": 6, "age_max_months": 216, "dose_text": "20 mg once daily for 10-14 days" } ], "peds_doses": null, "brands": [ { "trade_name": "ZINC SULFATE 10MG/5ML POWDER FOR SYRUP", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "CID", "price_egp": 5.0, "pack_count": null, "unit_price": null, "strength_mg": 10.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "SULFOZINC 10MG/5ML PD. FOR SUSP. 80ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "CID", "price_egp": 22.0, "pack_count": null, "unit_price": null, "strength_mg": 10.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ZINCOMIST 10MG/5ML SYRUP 120 ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ORCHIDIA", "price_egp": 50.0, "pack_count": null, "unit_price": null, "strength_mg": 10.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ZINC-SEDICO 10MG/5ML PD. FOR ORAL SOL.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "SEDICO", "price_egp": 7.0, "pack_count": null, "unit_price": null, "strength_mg": 10.0, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null }, { "trade_name": "ZINC-SEDICO 20MG/5ML PD. FOR ORAL SOL.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "SEDICO", "price_egp": 8.0, "pack_count": null, "unit_price": null, "strength_mg": 20.0, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null } ], "condition_id": "gastroenteritis-in-infants" }, { "id": 812, "generic": "Ondansetron", "line": 2, "is_adjunct": true, "form": "oral.solid", "strength_mg": 4.0, "adult_dose": "Not applicable - pediatric entry", "adult_duration": "single dose", "dose_source": "ESPGHAN/ESPID Evidence-Based Guidelines for Acute Gastroenteritis in Children 2014 for the indication, with the figures from Egyptian National Drug Formulary - GIT medicines 2025, ondansetron monograph (endf-git.txt): \"IV single dose: 0.15 mg/kg given immediately before chemotherapy (must not exceed 8 mg)\" and \"> 10 kg Up to 3 doses of 0.15 mg/kg IV every 4 hours 4 mg syrup or tablet every 12 hours\". The formulary states those figures for chemotherapy-induced vomiting; the gastroenteritis indication is the ESPGHAN guideline's, which is not held in this corpus.", "rationale": "Single oral dose enables successful oral rehydration in infants with severe vomiting avoiding IV access", "cautions": [ "SINGLE DOSE ONLY: Repeated doses increase risk of diarrhoea recurrence and electrolyte shift.", "Contraindicated in congenital long QT syndrome." ], "peds_mgkg_low": 0.15, "peds_mgkg_high": 0.15, "peds_max_mg": 4.0, "peds_basis": "dose", "peds_unit": "mg", "peds_note": "Single oral dose: 0.15 mg/kg (max 4 mg) for children >6 months with persistent vomiting preventing ORS", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": [ { "weight_kg": 10, "low_mg": 1.5, "high_mg": 1.5, "capped": false }, { "weight_kg": 20, "low_mg": 3, "high_mg": 3, "capped": false }, { "weight_kg": 30, "low_mg": 4, "high_mg": 4, "capped": true }, { "weight_kg": 40, "low_mg": 4, "high_mg": 4, "capped": true } ], "brands": [ { "trade_name": "DANOFRAN 4MG 5 F.C. TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "UP PHARMA", "price_egp": 70.0, "pack_count": 5, "unit_price": 14.0, "strength_mg": 4.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "SETRONOMET 4 MG 4 ORAL DIS. TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "AVERROES PHARMA", "price_egp": 78.0, "pack_count": null, "unit_price": null, "strength_mg": 4.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "IDIVOMTRON 4 MG 10 ORALLY DIS. TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "INTERNATIONAL DRUG AGENCY (IDI)", "price_egp": 144.0, "pack_count": null, "unit_price": null, "strength_mg": 4.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "EMEREST 4 MG 10 ORO-DISPERSIBLE TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "GLOBAL PHARMACEUTICAL INDUSTRIES", "price_egp": 188.0, "pack_count": null, "unit_price": null, "strength_mg": 4.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "IDIVOMTRON 4 MG/5ML SYRUP 50 ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "RAMEDA > INTERNATIONAL DRUG AGENCY (IDI)", "price_egp": 110.0, "pack_count": null, "unit_price": null, "strength_mg": 4.0, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null } ], "condition_id": "gastroenteritis-in-infants" } ] }