{ "schema_version": 1, "kind": "condition", "id": "functional-dyspepsia", "name": "Functional Dyspepsia", "category": "chronic", "sources": "Mirtazapine tablets US prescribing information, sections 2.1 and 3 (DailyMed SetID b6b31703-e77d-4d1a-b1ac-da972117e356, XLCare Pharmaceuticals): \"Starting dose: 15 mg once daily; may increase up to maximum recommended dose of 45 mg once daily\" and \"Tablets: 7.5 mg, 15 mg functionally scored, 30 mg functionally scored and 45 mg.\" The 45 mg ceiling is the label's own maximum; the 7.5 mg start is one strength below the label's 15 mg starting dose, and the label carries no functional dyspepsia indication. · ACG/CAG Clinical Guideline: Management of Dyspepsia 2017 for the indication, with the dose from Amitriptyline Hydrochloride 25 mg Film-coated Tablets SmPC section 4.2 (eMC product 13683), which starts depression dosing at \"Initially 25 mg 2 times daily (50 mg daily)\" and states \"Amitriptyline should not be used in children and adolescents aged less than 18 years\". The SmPC's indication is depression; the 10 mg night-time start for functional dyspepsia is from the ACG/CAG guideline, which is not held in this corpus. · ACG/CAG Clinical Guideline: Management of Dyspepsia 2017 · Egyptian National Drug Formulary (EDA) 2026 - Gastrointestinal Tract · Functional Dyspepsia - disease-level clinical article (functional-dyspepsia-clinical.txt) · Egyptian National Drug Formulary - Gastrointestinal Tract 2025 (domperidone monograph) · Egyptian National Drug Formulary - Gastrointestinal Tract 2025 (metoclopramide monograph) · Egyptian National Drug Formulary - Gastrointestinal Tract 2025 (famotidine monograph)", "review_status": "reviewed", "verified_against": "Mirtazapine tablets US prescribing information, sections 2.1 and 3 (DailyMed SetID b6b31703-e77d-4d1a-b1ac-da972117e356, XLCare Pharmaceuticals): \"Starting dose: 15 mg once daily; may increase up to maximum recommended dose of 45 mg once daily\" and \"Tablets: 7.5 mg, 15 mg functionally scored, 30 mg functionally scored and 45 mg.\" The 45 mg ceiling is the label's own maximum; the 7.5 mg start is one strength below the label's 15 mg starting dose, and the label carries no functional dyspepsia indication. · ACG/CAG Clinical Guideline: Management of Dyspepsia 2017 for the indication, with the dose from Amitriptyline Hydrochloride 25 mg Film-coated Tablets SmPC section 4.2 (eMC product 13683), which starts depression dosing at \"Initially 25 mg 2 times daily (50 mg daily)\" and states \"Amitriptyline should not be used in children and adolescents aged less than 18 years\". The SmPC's indication is depression; the 10 mg night-time start for functional dyspepsia is from the ACG/CAG guideline, which is not held in this corpus. · ACG/CAG Clinical Guideline: Management of Dyspepsia 2017 · Egyptian National Drug Formulary (EDA) 2026 - Gastrointestinal Tract · Functional Dyspepsia - disease-level clinical article (functional-dyspepsia-clinical.txt) · Egyptian National Drug Formulary - Gastrointestinal Tract 2025 (domperidone monograph) · Egyptian National Drug Formulary - Gastrointestinal Tract 2025 (metoclopramide monograph) · Egyptian National Drug Formulary - Gastrointestinal Tract 2025 (famotidine monograph)", "verified_date": "2026-08", "treatments": [ { "id": 784, "generic": "Omeprazole", "line": 1, "is_adjunct": false, "form": "oral.solid", "strength_mg": 20.0, "adult_dose": "20 mg once daily 30 minutes before breakfast", "adult_duration": "4-8 weeks", "dose_source": "ACG/CAG Clinical Guideline: Management of Dyspepsia 2017", "rationale": "Proton pump inhibitor that blocks gastric acid secretion at the parietal cell H+/K+-ATPase, used as empirical first-line therapy for dyspepsia once H. pylori has been tested for and red-flag causes excluded.", "cautions": [ "Test and treat for H. pylori prior to initiating uninvestigated long-term PPI therapy.", "In patients >55 years or with red flag symptoms (weight loss, dysphagia, anaemia, persistent vomiting), urgent endoscopy is mandatory before starting PPI.", "Attempt step-down or discontinuation after 4-8 weeks." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "Specialist pediatric gastroenterology use only", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [ { "trade_name": "OMEGASTAZOLE 20MG 14 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "RIVA PHARMA S.A.E.", "price_egp": 18.0, "pack_count": 14, "unit_price": 1.29, "strength_mg": 20.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "OMEPRAL 20MG 14 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MEMPHIS", "price_egp": 32.0, "pack_count": 14, "unit_price": 2.29, "strength_mg": 20.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "RISEK 20 MG 28 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "JULPHAR", "price_egp": 75.0, "pack_count": 28, "unit_price": 2.68, "strength_mg": 20.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "OMISEC 20MG 14CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "THE UNITED PHARMACEUTICALS CO LTD-JORDAN > MODERN PHARMA", "price_egp": 42.0, "pack_count": 14, "unit_price": 3.0, "strength_mg": 20.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "EPIRAZOLE 20MG 14CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EIPICO", "price_egp": 44.0, "pack_count": 14, "unit_price": 3.14, "strength_mg": 20.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "OMEPAK 20 MG 14 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "SEDICO", "price_egp": 50.0, "pack_count": 14, "unit_price": 3.57, "strength_mg": 20.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "RISEK 20 MG 14 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "JULPHAR", "price_egp": 57.0, "pack_count": 14, "unit_price": 4.07, "strength_mg": 20.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "NAPIZOLE 20MG 14 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "GLOBAL NAPI PHARMACEUTICALS", "price_egp": 62.0, "pack_count": 14, "unit_price": 4.43, "strength_mg": 20.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null } ], "condition_id": "functional-dyspepsia" }, { "id": 787, "generic": "Referral & safety-netting (no drug therapy)", "line": 1, "is_adjunct": false, "form": null, "strength_mg": null, "adult_dose": null, "adult_duration": null, "dose_source": "Functional Dyspepsia - disease-level clinical article (functional-dyspepsia-clinical.txt)", "rationale": "Carries the referral criteria and warning signs for this condition, which apply whichever treatment is chosen.", "cautions": [ "RED FLAG - Alarm symptoms (unintentional weight loss, dysphagia, odynophagia, unexplained iron-deficiency anemia, persistent vomiting, a detectable mass/lymphadenopathy, family history of upper GI cancer) require endoscopic evaluation rather than empiric drug therapy." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": null, "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [], "condition_id": "functional-dyspepsia" }, { "id": 785, "generic": "Itopride", "line": 2, "is_adjunct": false, "form": "oral.solid", "strength_mg": 50.0, "adult_dose": "50 mg 3 times daily before meals", "adult_duration": "4-8 weeks", "dose_source": "Egyptian National Drug Formulary (EDA) 2026 - Gastrointestinal Tract", "rationale": "Prokinetic agent with dopamine D2 and AChE inhibitory action; widely used in Egypt with lower cardiac/extrapyramidal risk than metoclopramide", "cautions": [ "Useful for postprandial distress syndrome (fullness, early satiety).", "Avoid in GI haemorrhage, obstruction, or perforation.", "Discontinue if galactorrhea or gynecomastia occurs." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "Not recommended in children", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [ { "trade_name": "GANAMOTIL 50 MG 30 F.C.TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "INTERNATIONAL DRUG AGENCY (IDI) > NOVELL PHARMA", "price_egp": 26.25, "pack_count": 30, "unit_price": 0.88, "strength_mg": 50.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "EMA ITOPRIDE 50 MG 30 TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "PHAROPHARMA > EMA PHARM", "price_egp": 48.0, "pack_count": 30, "unit_price": 1.6, "strength_mg": 50.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "GANTOLIEF 50 MG 30 F.C.TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "GLOBAL NAPI PHARMACEUTICALS", "price_egp": 60.0, "pack_count": 30, "unit_price": 2.0, "strength_mg": 50.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "GAROPRIDE 50 MG 30 F.C.TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EVA PHARMA", "price_egp": 63.0, "pack_count": 30, "unit_price": 2.1, "strength_mg": 50.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ITOMASH 50 MG 30 TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MASH PREMIERE", "price_egp": 63.0, "pack_count": 30, "unit_price": 2.1, "strength_mg": 50.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "GANATON 50 MG 30 F.C.TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "KAHIRA > ABBOTT LABORATORIES", "price_egp": 90.0, "pack_count": 30, "unit_price": 3.0, "strength_mg": 50.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ITOPRIDE 50 MG 30 SCORED TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "BORG", "price_egp": 54.0, "pack_count": null, "unit_price": null, "strength_mg": 50.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ALKAPRIDE 50 MG 30 SCORED TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "FUTURE PHARMACEUTICAL INDUSTRIES (FPI) > UTOPIA", "price_egp": 90.0, "pack_count": null, "unit_price": null, "strength_mg": 50.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null } ], "condition_id": "functional-dyspepsia" }, { "id": 789, "generic": "Domperidone", "line": 2, "is_adjunct": false, "form": "oral.solid", "strength_mg": 10.0, "adult_dose": "10 mg up to three times daily (maximum 30 mg/day)", "adult_duration": "Maximum one week", "dose_source": "Egyptian National Drug Formulary - Gastrointestinal Tract 2025 (domperidone monograph)", "rationale": "The disease article names domperidone and metoclopramide as the prokinetics for functional dyspepsia; the card carried only itopride, which the article does not mention.", "cautions": [ "Children under 12 years and adolescents weighing less than 35 kg are not recommended.", "Use at the lowest effective dose for the shortest duration necessary - maximum duration one week.", "Contraindicated with known existing prolongation of cardiac conduction intervals, particularly QTc, significant electrolyte disturbances, or underlying cardiac disease such as congestive heart failure.", "Contraindicated in moderate or severe hepatic impairment.", "Contraindicated where stimulating gastric motility is dangerous - gastrointestinal haemorrhage, mechanical obstruction, or perforation." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "ENDF: children under 12 years and adolescents weighing less than 35 kg are not recommended.", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": 144.0, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [ { "trade_name": "DOMPIDONE 10 MG 30 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ARAB DRUG COMPANY (ADCO)", "price_egp": 17.25, "pack_count": 30, "unit_price": 0.57, "strength_mg": 10.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "SYNCHROGIT 10MG 20 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "RAMEDA", "price_egp": 15.0, "pack_count": 20, "unit_price": 0.75, "strength_mg": 10.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "MOTINORM 10MG 30 TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "GLAXO SMITHKLINE", "price_egp": 28.25, "pack_count": 30, "unit_price": 0.94, "strength_mg": 10.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "GASTROMOTIL 10MG 20 F.C. TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EIPICO", "price_egp": 26.0, "pack_count": 20, "unit_price": 1.3, "strength_mg": 10.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "MOTILIUM 10MG 40 F.C.TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MINA PHARM > JANSSEN CILAG", "price_egp": 100.0, "pack_count": 40, "unit_price": 2.5, "strength_mg": 10.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "GASTRONORM 10MG 5 SACHET", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "SIGMA", "price_egp": 5.5, "pack_count": null, "unit_price": null, "strength_mg": 10.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "MOTIL FAST 10 MG 10 EFF. SACHETS", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "AMOUN", "price_egp": 26.0, "pack_count": null, "unit_price": null, "strength_mg": 10.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "DONARAX 10 MG 30 ORODISPERSIBLE TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "JEDCO INT. CO. FOR PHARMACEUTICALS > ARAX PHARM. IND.", "price_egp": 39.0, "pack_count": null, "unit_price": null, "strength_mg": 10.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "DOMPIDONE 100MG/100ML ORAL SUSP. 100ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ARAB DRUG COMPANY (ADCO)", "price_egp": 6.0, "pack_count": null, "unit_price": null, "strength_mg": 100.0, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null }, { "trade_name": "MOTILIUM 1MG/ML SUSP. 100ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MINA PHARM > JANSSEN CILAG", "price_egp": 15.75, "pack_count": null, "unit_price": null, "strength_mg": 1.0, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null } ], "condition_id": "functional-dyspepsia" }, { "id": 790, "generic": "Metoclopramide", "line": 2, "is_adjunct": false, "form": "oral.solid", "strength_mg": 10.0, "adult_dose": "10 mg up to three times daily (maximum 30 mg/day or 0.5 mg/kg/day)", "adult_duration": "Maximum 5 days", "dose_source": "Egyptian National Drug Formulary - Gastrointestinal Tract 2025 (metoclopramide monograph)", "rationale": "Named with domperidone as the guideline's prokinetic option for functional dyspepsia. The ENDF caps treatment at 5 days because of the extrapyramidal risk.", "cautions": [ "Contraindicated in a history of neuroleptic or metoclopramide-induced tardive dyskinesia.", "Contraindicated in neonates or children aged under 1 year - increased risk of extrapyramidal disorders and methaemoglobinaemia.", "Contraindicated in epilepsy and in Parkinson's disease.", "Contraindicated in combination with levodopa or dopaminergic agonists.", "Contraindicated where stimulating gastrointestinal motility may be hazardous - mechanical obstruction, perforation, or haemorrhage.", "The maximum duration is 5 days." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "ENDF contraindicates metoclopramide in neonates and children under 1 year; the monograph gives no functional-dyspepsia paediatric dose, so none is stated here.", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [ { "trade_name": "CLOPRAM 10MG 20 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EL NASR", "price_egp": 3.0, "pack_count": 20, "unit_price": 0.15, "strength_mg": 10.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "PLEMAZOL 10MG 20 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "CID", "price_egp": 3.2, "pack_count": 20, "unit_price": 0.16, "strength_mg": 10.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "VOMAWAY 10MG 20 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MEMPHIS", "price_egp": 8.5, "pack_count": 20, "unit_price": 0.42, "strength_mg": 10.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "PRIMPERAN 10MG 10 SCORED TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "SANOFI", "price_egp": 10.5, "pack_count": null, "unit_price": null, "strength_mg": 10.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null } ], "condition_id": "functional-dyspepsia" }, { "id": 791, "generic": "Famotidine", "line": 2, "is_adjunct": false, "form": "oral.solid", "strength_mg": 20.0, "adult_dose": "20 mg twice daily (mild, non-erosive); 40 mg twice daily (moderate, erosive)", "adult_duration": null, "dose_source": "Egyptian National Drug Formulary - Gastrointestinal Tract 2025 (famotidine monograph)", "rationale": "An H2-receptor antagonist is the disease article's named alternative when a proton pump inhibitor is unsuitable; the card offered only omeprazole.", "cautions": [ "The ENDF dose quoted here is the GERD regimen - the formulary has no functional-dyspepsia entry for famotidine, and the indication comes from the disease article." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "The ENDF famotidine monograph states paediatric doses for peptic ulcer and GERD, not for functional dyspepsia; no paediatric figure is carried here.", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [ { "trade_name": "FAMOTAK 20MG 20 F.C.TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "SEDICO", "price_egp": 28.0, "pack_count": 20, "unit_price": 1.4, "strength_mg": 20.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "GASTRODOMINA 20MG 20 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MUP > ALMIRALL PRODES-SPAIN", "price_egp": 28.0, "pack_count": 20, "unit_price": 1.4, "strength_mg": 20.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ANTODINE 20 MG 30 F.C.TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "AMOUN", "price_egp": 60.0, "pack_count": 30, "unit_price": 2.0, "strength_mg": 20.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "FAMOTIN 20MG 20TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MEMPHIS", "price_egp": 40.0, "pack_count": 20, "unit_price": 2.0, "strength_mg": 20.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "RANI-F 20MG 6 SACHETS", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "PHARCO", "price_egp": 42.0, "pack_count": null, "unit_price": null, "strength_mg": 20.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null } ], "condition_id": "functional-dyspepsia" }, { "id": 786, "generic": "Amitriptyline", "line": 3, "is_adjunct": false, "form": "oral.solid", "strength_mg": 10.0, "adult_dose": "10 mg once daily at bedtime, titrate to 25 mg at bedtime if needed", "adult_duration": "8-12 weeks", "dose_source": "ACG/CAG Clinical Guideline: Management of Dyspepsia 2017 for the indication, with the dose from Amitriptyline Hydrochloride 25 mg Film-coated Tablets SmPC section 4.2 (eMC product 13683), which starts depression dosing at \"Initially 25 mg 2 times daily (50 mg daily)\" and states \"Amitriptyline should not be used in children and adolescents aged less than 18 years\". The SmPC's indication is depression; the 10 mg night-time start for functional dyspepsia is from the ACG/CAG guideline, which is not held in this corpus.", "rationale": "Low-dose tricyclic antidepressant acts as a visceral neuromodulator for refractory epigastric pain syndrome", "cautions": [ "Used at low neuromodulatory doses (10-25 mg), not antidepressant doses.", "Anticholinergic side effects include dry mouth, sedation, and urinary retention.", "Avoid in cardiac arrhythmia or recent MI.", "Avoid in elderly patients, and in severe cardiovascular disease or arrhythmias. Amitriptyline - StatPearls - NCBI Bookshelf (NBK537225) puts amitriptyline on the American Geriatrics Society's Beers list, to be avoided in the elderly because its anticholinergic effect is so strong." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "Not recommended for functional dyspepsia in children", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [ { "trade_name": "TRYPTIZOL 10 MG 20 TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "KAHIRA", "price_egp": 10.0, "pack_count": 20, "unit_price": 0.5, "strength_mg": 10.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "TRYPTIZOL 10 MG 60 TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "KAHIRA", "price_egp": 30.0, "pack_count": 60, "unit_price": 0.5, "strength_mg": 10.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "GRANITYLLIN 25MG/5ML SYP. 120 ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "GRAND PHARMA > DELTA GRAND PHARMA", "price_egp": 5.0, "pack_count": null, "unit_price": null, "strength_mg": 25.0, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null }, { "trade_name": "ZINOTRAVAL 25MG/5ML SYP. 120 ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "DEBEIKY > PHARMACHEMIC", "price_egp": 10.0, "pack_count": null, "unit_price": null, "strength_mg": 25.0, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null } ], "condition_id": "functional-dyspepsia" }, { "id": 788, "generic": "Mirtazapine", "line": 3, "is_adjunct": false, "form": "oral.solid", "strength_mg": null, "adult_dose": "Begin at 7.5 mg, taken 1 hour before going to bed. The sensible course is a low starting dose climbed slowly, to a ceiling of 45 mg daily.", "adult_duration": null, "dose_source": "Mirtazapine tablets US prescribing information, sections 2.1 and 3 (DailyMed SetID b6b31703-e77d-4d1a-b1ac-da972117e356, XLCare Pharmaceuticals): \"Starting dose: 15 mg once daily; may increase up to maximum recommended dose of 45 mg once daily\" and \"Tablets: 7.5 mg, 15 mg functionally scored, 30 mg functionally scored and 45 mg.\" The 45 mg ceiling is the label's own maximum; the 7.5 mg start is one strength below the label's 15 mg starting dose, and the label carries no functional dyspepsia indication.", "rationale": "Atypical antidepressant that improves early satiation, nutrient tolerance, and gastrointestinal-specific anxiety in functional dyspepsia.", "cautions": [ "Higher doses may induce sedation without enhancing efficacy; cautiously titrate based on symptom response.", "Doses must be gradually tapered when discontinuing treatment.", "Begin low and climb slowly, to a ceiling of 45 mg daily." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "No paediatric dose is stated in the sources held for this drug.", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [ { "trade_name": "RAMIZIPINE 30 MG 30 F.C. TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "AUG PHARMA", "price_egp": 81.0, "pack_count": 30, "unit_price": 2.7, "strength_mg": 30.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "RAPIZAPINE 30 MG 10 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EUROPEAN EGYPTIAN PHARM. IND.", "price_egp": 29.4, "pack_count": 10, "unit_price": 2.94, "strength_mg": 30.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "MIRTADEPINE 30 MG 10 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ALFACURE PHARMACEUTICALS", "price_egp": 37.0, "pack_count": 10, "unit_price": 3.7, "strength_mg": 30.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "APRIMERTAZ 30 MG 30 F.C.TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "WADI ELNEEL BENTA", "price_egp": 135.0, "pack_count": 30, "unit_price": 4.5, "strength_mg": 30.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "MIRPRESION 30 MG 30 TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "BIOMED", "price_egp": 151.5, "pack_count": 30, "unit_price": 5.05, "strength_mg": 30.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ZAPIMERT 30 MG 30 F.C. TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "DEBEIKY > GROWTH PHARMA", "price_egp": 165.0, "pack_count": 30, "unit_price": 5.5, "strength_mg": 30.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "REMERON 30 MG 10 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ORGANON > MULTIPHARMA", "price_egp": 135.0, "pack_count": 10, "unit_price": 13.5, "strength_mg": 30.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "MIRTIMASH 30 MG 30 SCORED F.C. TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MASH PREMIERE", "price_egp": 177.0, "pack_count": null, "unit_price": null, "strength_mg": 30.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null } ], "condition_id": "functional-dyspepsia" } ] }