{ "schema_version": 1, "kind": "condition", "id": "epididymo-orchitis", "name": "Epididymo-orchitis (Acute)", "category": "infectious", "sources": "Egyptian National Drug Formulary - Antimicrobial 2023 · BASHH UK National Guideline for the Management of Epididymo-orchitis 2020 · EAU Guidelines on Urological Infections 2023 · Azithromycin DailyMed label, SetID 01649d79-4677-4577-a3e4-e054f3f9fc3b, section 2", "review_status": "reviewed", "verified_against": "Egyptian National Drug Formulary - Antimicrobial 2023 · BASHH UK National Guideline for the Management of Epididymo-orchitis 2020 · EAU Guidelines on Urological Infections 2023 · Epididymo-orchitis (Acute) - disease-level clinical article (epididymo-orchitis-clinical.txt)", "verified_date": "2026-08", "treatments": [ { "id": 685, "generic": "Ceftriaxone", "line": 1, "is_adjunct": false, "form": "injection", "strength_mg": 1000.0, "adult_dose": "1 g IM single dose PLUS Doxycycline 100 mg BID for 14 days for sexually transmitted acute epididymo-orchitis", "adult_duration": "single IM dose", "dose_source": "Egyptian National Drug Formulary - Antimicrobial 2023 (ceftriaxone monograph), General Adult Dosage: \"IV or IM 1-2 g once or devided twice daily\", 1 gm vial; the sexually-transmitted epididymo-orchitis regimen is from the BASHH UK National Guideline for the Management of Epididymo-orchitis 2020, which is not held in this corpus.", "rationale": "Cephalosporin that covers Neisseria gonorrhoeae, given together with doxycycline for chlamydia coverage, in sexually transmitted acute epididymo-orchitis.", "cautions": [ "ALWAYS rule out testicular torsion urgently in any young male presenting with acute scrotal pain.", "Provide partner notification and STI screening for N. gonorrhoeae and C. trachomatis.", "Reconstitute with 1% lidocaine for IM injection to reduce pain." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "Specialist pediatric urology management", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [ { "trade_name": "ZOXIDEL 1 GM PD. FOR I.M. INJ.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "RAMEDA > DELTA PHARMA", "price_egp": 22.0, "pack_count": null, "unit_price": null, "strength_mg": 1000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "CEFTRIAXONE SODIUM 1 GM I.M.VIAL (KAHIRA)", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "KAHIRA", "price_egp": 29.0, "pack_count": null, "unit_price": null, "strength_mg": 1000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ZOXIDEL 1 GM PD. FOR I.V. INJ.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "RAMEDA > DELTA PHARMA", "price_egp": 29.0, "pack_count": null, "unit_price": null, "strength_mg": 1000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "WINTRIAXONE 1 GM PD. FOR I.V INJ.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "SANOFI", "price_egp": 48.0, "pack_count": null, "unit_price": null, "strength_mg": 1000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "VOTRIAXONE 1 GM I.M VIAL", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "CHEMIPHARM", "price_egp": 56.0, "pack_count": null, "unit_price": null, "strength_mg": 1000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "OFRAMAX 1 GM I.M. VIAL", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "RAMEDA > SUN PHARMA EGYPT LIMITED", "price_egp": 71.0, "pack_count": null, "unit_price": null, "strength_mg": 1000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "TRIAXONE 1 GM I.M. VIAL", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "TABUK PHARMACEUTICAL MANUFACTURING COMPANY > TABUK PHARMA", "price_egp": 106.0, "pack_count": null, "unit_price": null, "strength_mg": 1000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "TRIAXONE 1 GM I.V VIAL", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "TABUK PHARMACEUTICAL MANUFACTURING COMPANY > TABUK PHARMA", "price_egp": 106.0, "pack_count": null, "unit_price": null, "strength_mg": 1000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null } ], "condition_id": "epididymo-orchitis" }, { "id": 688, "generic": "Referral & safety-netting (no drug therapy)", "line": 1, "is_adjunct": false, "form": null, "strength_mg": null, "adult_dose": null, "adult_duration": null, "dose_source": "Epididymo-orchitis (Acute) - disease-level clinical article (epididymo-orchitis-clinical.txt)", "rationale": "Carries the referral criteria and warning signs for this condition, which apply whichever treatment is chosen.", "cautions": [ "RED FLAG - Urgent referral and urological evaluation are needed to rule out testicular torsion, a surgical emergency, in acute scrotal pain." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": null, "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [], "condition_id": "epididymo-orchitis" }, { "id": 687, "generic": "Levofloxacin", "line": 2, "is_adjunct": false, "form": "oral.solid", "strength_mg": 500.0, "adult_dose": "500 mg once daily for 10-14 days when enteric organisms (E. coli) are suspected (age >35 years or post-urological procedure)", "adult_duration": "10-14 days", "dose_source": "Egyptian National Drug Formulary - Antimicrobial 2023 (levofloxacin monograph): \"Conventional dosing: Adult: Oral/IV :500-750 mg once daily\". The enteric-organism indication and the 10-to-14-day course are from the EAU Guidelines on Urological Infections 2023, which is not held in this corpus.", "rationale": "Fluoroquinolone used instead of the ceftriaxone-doxycycline regimen when enteric organisms such as E. coli are the likely cause, typically in older men or those with a recent urological procedure.", "cautions": [ "Obtain urine culture before starting fluoroquinolone therapy.", "There is a risk of tendinitis, tendon rupture, and QT prolongation." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "Contraindicated in growing children", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [ { "trade_name": "FLOXABACT 500 MG 10 F.C.TABS.(NOW LEVOFLOXACIN-EVA)", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EVA PHARMA", "price_egp": 40.0, "pack_count": 10, "unit_price": 4.0, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "LEVOMAGICTAM 500 MG 5 F.C.TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MEDIZEN PHARMACEUTICAL INDUSTRIES > MAGIC PHARMA-EGYPT", "price_egp": 27.0, "pack_count": 5, "unit_price": 5.4, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "EXACINOP 500 MG 10 F.C.TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EL-OBOUR > MASSA GROUP PHARMA", "price_egp": 65.0, "pack_count": 10, "unit_price": 6.5, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ROYAFLOXACIN 500 MG 10 F.C.TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MEDIZEN PHARMACEUTICAL INDUSTRIES > SATO PHARMA", "price_egp": 92.0, "pack_count": 10, "unit_price": 9.2, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "TAVIXINOR 500 MG 5 F.C. TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MASH PREMIERE > SAS PHARMA", "price_egp": 64.5, "pack_count": 5, "unit_price": 12.9, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "BIOWORLD 500 MG 10 F.C. TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EGPI > BIOWORLD", "price_egp": 133.0, "pack_count": 10, "unit_price": 13.3, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "TAVANIC 500 MG 5 F.C.TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "SANOFI", "price_egp": 192.0, "pack_count": 5, "unit_price": 38.4, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ALFASPECT 500 MG 5 S.F.C.TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "SPIMACO PHARMACEUTICAL INDUSTRIES > INNOGEN PHARMA", "price_egp": 70.0, "pack_count": null, "unit_price": null, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null } ], "condition_id": "epididymo-orchitis" }, { "id": 686, "generic": "Doxycycline", "line": 1, "is_adjunct": true, "form": "oral.solid", "strength_mg": 100.0, "adult_dose": "100 mg twice daily for 14 days co-administered with Ceftriaxone", "adult_duration": "14 days", "dose_source": "Egyptian National Drug Formulary - Antimicrobial 2023 (doxycycline monograph): \"Usual dosage range: Oral: IR and most ER formulations: 100 to 200 mg/day in 1 to 2 divided doses\", 100 mg capsules; the 14-day epididymo-orchitis course is from the BASHH UK National Guideline for the Management of Epididymo-orchitis 2020, which is not held in this corpus.", "rationale": "Adjunct antibiotic co-administered with ceftriaxone to cover Chlamydia trachomatis, the other major sexually transmitted cause of acute epididymo-orchitis; it does not treat gonococcal infection on its own.", "cautions": [ "Take with a full glass of water and remain upright for 30 minutes to prevent esophageal ulceration.", "There is a photosensitivity risk with doxycycline." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "Not recommended under 8 years of age due to tooth discoloration", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [ { "trade_name": "FARCODOXIN 100MG 10 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "PHARCO", "price_egp": 11.0, "pack_count": 10, "unit_price": 1.1, "strength_mg": 100.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "DOXY M.R.100 MG 10 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ADWIA", "price_egp": 12.0, "pack_count": 10, "unit_price": 1.2, "strength_mg": 100.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "GRANUDOXY 100MG 10 F.C. TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "GLOBAL NAPI PHARMACEUTICALS > PIERRE FRANCE", "price_egp": 12.0, "pack_count": 10, "unit_price": 1.2, "strength_mg": 100.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "DOXYDOX 100 MG 10 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EIPICO", "price_egp": 23.0, "pack_count": 10, "unit_price": 2.3, "strength_mg": 100.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "DOXYMYCIN 100 MG 10 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EL NILE.", "price_egp": 30.0, "pack_count": 10, "unit_price": 3.0, "strength_mg": 100.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "TABOCINE 100MG 10 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "TABUK PHARMACEUTICAL MANUFACTURING COMPANY > TABUK PHARMA", "price_egp": 46.0, "pack_count": 10, "unit_price": 4.6, "strength_mg": 100.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "VIBRAMYCIN 100MG 10 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "PFIZER", "price_egp": 65.0, "pack_count": 10, "unit_price": 6.5, "strength_mg": 100.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null } ], "condition_id": "epididymo-orchitis" }, { "id": 689, "generic": "Azithromycin", "line": 1, "is_adjunct": true, "form": "oral.solid", "strength_mg": 500.0, "adult_dose": "1 g by mouth as a single dose", "adult_duration": "Single dose", "dose_source": "Azithromycin DailyMed label, SetID 01649d79-4677-4577-a3e4-e054f3f9fc3b, section 2 - verbatim: \"Non-gonococcal urethritis and cervicitis One single 1 gram dose.\"", "rationale": "The card's chlamydial cover is a 10-day course of doxycycline; some men cannot take it and some will not finish it, and a single 1 g dose given in the clinic covers the same organism alongside the ceftriaxone injection they are already getting.", "cautions": [ "It does not cover gonorrhoea at this dose - the ceftriaxone injection is still needed, not replaced.", "Doxycycline remains the preferred partner for ceftriaxone; use azithromycin when doxycycline cannot be taken or ten days of adherence is unrealistic.", "Treat the sexual partners and advise abstinence until both are treated, or the man will be back.", "Azithromycin can prolong the QT interval; take care in cardiac disease or with other QT-prolonging drugs." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "Not applicable - sexually transmitted epididymo-orchitis is an adult and adolescent presentation, and no paediatric dose for it appears in the sources opened.", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [ { "trade_name": "AZATRIBACT 500MG 3 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "RIVA PHARMA S.A.E.", "price_egp": 13.5, "pack_count": 3, "unit_price": 4.5, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "GIGAZOCIN 500MG 5 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EGPI > PIONEER", "price_egp": 27.5, "pack_count": 5, "unit_price": 5.5, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "SYSTYMYCIN 500MG 3 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EGPI > NOVELL PHARMA", "price_egp": 21.5, "pack_count": 3, "unit_price": 7.17, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "AZITHROMASH 500 MG 3 F.C. TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MASH PREMIERE", "price_egp": 48.0, "pack_count": 3, "unit_price": 16.0, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "AZALIDE 500MG 3 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "UP PHARMA", "price_egp": 52.0, "pack_count": 3, "unit_price": 17.33, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "AZROLID 500 MG 6 F.C.TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "AMRIYA", "price_egp": 126.0, "pack_count": 6, "unit_price": 21.0, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ZERAMERATE 500 MG", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EGPI > GAMMA PHARMA", "price_egp": 28.5, "pack_count": null, "unit_price": null, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "DISTABCIN 500 MG 3 DISPERSIBLE TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EGPI", "price_egp": 43.5, "pack_count": null, "unit_price": null, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ZITHRODOSE 100MG/5ML SUSP. 15ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EL-OBOUR > AVERROES PHARMA-EGYPT", "price_egp": 12.0, "pack_count": null, "unit_price": null, "strength_mg": 100.0, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null }, { "trade_name": "ZITHROPHATE 200MG/5ML SUSP. 15ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ORGANO PHARMA > NOVELL PHARMA", "price_egp": 12.75, "pack_count": null, "unit_price": null, "strength_mg": 200.0, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null } ], "condition_id": "epididymo-orchitis" } ] }