{ "schema_version": 1, "kind": "condition", "id": "drug-allergy", "name": "Drug Allergy", "category": "acute", "sources": "Egyptian National Drug Formulary - endocrine.pdf, Prednisolone monograph (chapter PDF p183) · Egyptian National Drug Formulary - respiratory-2026.pdf, Cetirizine monograph (chapter PDF p14)", "review_status": "reviewed", "verified_against": "Egyptian National Drug Formulary - endocrine.pdf, Prednisolone monograph (chapter PDF p183) · Egyptian National Drug Formulary - respiratory-2026.pdf, Cetirizine monograph (chapter PDF p14)", "verified_date": "2026-08", "treatments": [ { "id": 634, "generic": "Cetirizine", "line": 1, "is_adjunct": false, "form": "oral.solid", "strength_mg": null, "adult_dose": "10 mg once daily by mouth", "adult_duration": "As directed, until the reaction settles after the causative drug is stopped", "dose_source": "Egyptian National Drug Formulary - respiratory-2026.pdf, Cetirizine monograph (chapter PDF p14)", "rationale": "Oral antihistamine to control itching, urticaria, and rash from a drug allergy once the culprit drug is stopped; first-line for a mild-to-moderate reaction.", "cautions": [ "Does not treat anaphylaxis - for stridor, wheeze, facial/tongue swelling, or hypotension, give IM adrenaline immediately and arrange emergency transfer; do not rely on an antihistamine.", "Sedation is possible, though less than with first-generation antihistamines; caution with driving/operating machinery.", "Reduce the dose in significant renal impairment.", "Watch for skin blistering or mucosal involvement (possible Stevens-Johnson syndrome/TEN) - stop the drug and refer urgently rather than treating as a simple rash." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "Oral: children 2-6 years 2.5 mg once or twice daily; children 6-12 years 5 mg twice daily (or 10 mg once, depending on severity); adolescents over 12 years 10 mg once daily.", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": [ { "label": "2 to under 6 years", "age_min_months": 24, "age_max_months": 71, "dose_text": "2.5 mg once or twice daily" }, { "label": "6 to under 12 years", "age_min_months": 72, "age_max_months": 143, "dose_text": "5 mg twice daily (or 10 mg once, depending on severity)" }, { "label": "12 years and over", "age_min_months": 144, "age_max_months": 216, "dose_text": "10 mg once daily" } ], "peds_doses": null, "brands": [ { "trade_name": "EPIRIZINE 10 MG 10 TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EIPICO", "price_egp": 15.5, "pack_count": 10, "unit_price": 1.55, "strength_mg": 10.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "CETRITIN 10MG 20 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EL NILE.", "price_egp": 42.0, "pack_count": 20, "unit_price": 2.1, "strength_mg": 10.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "TOMAZINE 10MG 30 F.C. TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ALFACURE PHARMACEUTICALS", "price_egp": 63.0, "pack_count": 30, "unit_price": 2.1, "strength_mg": 10.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "CETRAK 10 MG 20 TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "PHARCO", "price_egp": 68.0, "pack_count": 20, "unit_price": 3.4, "strength_mg": 10.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "HISTAZINE-1 10 MG 20 TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "AMRIYA", "price_egp": 68.0, "pack_count": 20, "unit_price": 3.4, "strength_mg": 10.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ZYRTEC 10 MG 20 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "GLAXO SMITHKLINE", "price_egp": 100.0, "pack_count": 20, "unit_price": 5.0, "strength_mg": 10.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "CETRICHEW 10MG 20 CHEWABLE F.C. TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "AL ROWAD PHARMACEUTICAL INDUSTRIAL CO.", "price_egp": 15.0, "pack_count": null, "unit_price": null, "strength_mg": 10.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "HISTA CHEW 10 MG 20 CHEWABLE TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ARAB CAPS > ADVOCURE", "price_egp": 15.0, "pack_count": null, "unit_price": null, "strength_mg": 10.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "LERGFREE 5MG/5ML SYRUP 120ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "DEBEIKY", "price_egp": 9.0, "pack_count": null, "unit_price": null, "strength_mg": 5.0, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null }, { "trade_name": "EPIRIZINE 5MG/ML SYRUP 60 ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EIPICO", "price_egp": 19.0, "pack_count": null, "unit_price": null, "strength_mg": 5.0, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null } ], "condition_id": "drug-allergy" }, { "id": 635, "generic": "Prednisolone", "line": 2, "is_adjunct": true, "form": "oral.solid", "strength_mg": null, "adult_dose": "5 to 60 mg/day as a single dose or in 2 to 4 divided doses, tapered to the lowest dose that controls symptoms", "adult_duration": "Short course, tapered off; avoid abrupt withdrawal if dose is 40 mg/day or more, or treatment has run 3 weeks or more", "dose_source": "Egyptian National Drug Formulary - endocrine.pdf, Prednisolone monograph (chapter PDF p183)", "rationale": "Added on top of an antihistamine for a more extensive or troublesome allergic reaction once the causative drug is stopped, to dampen the immune response; not a treatment for anaphylaxis itself.", "cautions": [ "Does not treat anaphylaxis and is not a substitute for adrenaline in a severe reaction.", "Avoid abrupt withdrawal after doses of 40 mg/day or more, or after 3 weeks or more of treatment - taper the dose.", "Use with caution in diabetes (raises blood glucose), peptic ulcer disease, active or latent infection (including TB, which is not rare in Egypt), and osteoporosis.", "Watch for skin blistering or mucosal involvement (possible Stevens-Johnson syndrome/TEN) - refer urgently rather than just adding a steroid course." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "General anti-inflammatory/immunosuppressive dosing: 0.1 to 2 mg/kg/day (or 4 to 60 mg/m2 BSA/day) in 1 to 4 divided doses; use the lowest dose that controls the reaction and taper gradually.", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [ { "trade_name": "HOSTACORTIN H 5MG 30 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "SANOFI", "price_egp": 12.0, "pack_count": 30, "unit_price": 0.4, "strength_mg": 5.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "PREDNISOLONE 5 MG 20 TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ARAB DRUG COMPANY (ADCO)", "price_egp": 24.0, "pack_count": 20, "unit_price": 1.2, "strength_mg": 5.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "PREDILONE 5MG 10 TAB. (25 STRIPS PACK)", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "KAHIRA", "price_egp": 250.0, "pack_count": 10, "unit_price": 25.0, "strength_mg": 5.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "PREDNISOLONE-EVA 5 MG 30 ORODISPERSIBLE TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EVA PHARMA", "price_egp": 79.5, "pack_count": null, "unit_price": null, "strength_mg": 5.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "SOLUPRED ORO 5 MG 30 ORODISPERSIBLE TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "SANOFI WINTHROP > SANOFI", "price_egp": 84.0, "pack_count": null, "unit_price": null, "strength_mg": 5.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "PREDNISOLONE 20 MG 20 ORODISPERSIBLE TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ARAB DRUG COMPANY (ADCO)", "price_egp": 115.0, "pack_count": null, "unit_price": null, "strength_mg": 20.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "XILONE 20 MG 20 ORODISPERSABLE TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EUROPEAN EGYPTIAN PHARM. IND.", "price_egp": 142.0, "pack_count": null, "unit_price": null, "strength_mg": 20.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "DISPRELONE-OD 20 MG 30 ORODISPERSABLE TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ANDALOUS PHARMA", "price_egp": 202.5, "pack_count": null, "unit_price": null, "strength_mg": 20.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ACETASEE 1% EYE DROPS (SUSP.) 5 ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "RAMEDA", "price_egp": 7.5, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null }, { "trade_name": "PREDNIS 5MG/5ML SYRUP 100 ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "PHAROPHARMA", "price_egp": 9.5, "pack_count": null, "unit_price": null, "strength_mg": 5.0, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null } ], "condition_id": "drug-allergy" } ] }