{ "schema_version": 1, "kind": "condition", "id": "de-quervain-tenosynovitis", "name": "De Quervain tenosynovitis", "category": "chronic", "sources": "Kenalog Intra-articular / Intramuscular Injection (triamcinolone acetonide 40 mg/ml) SmPC sections 4.1 and 4.2 (eMC product 6748), which carries tenosynovitis as a labelled indication: \"For intra-articular administration or injection into tendon sheaths and bursae, the dose of Kenalog Injection may vary from 5 mg to 10 mg (0.125 - 0.25 ml) for smaller joints and up to 40 mg (1.0 ml) for larger joints, depending on the specific disease entity being treated.\" The label's band for a small structure stops at 10 mg while the range given here reaches 20 mg, under the label's 40 mg single-site ceiling. · AAOS Clinical Practice Guidelines · Naproxen 500 mg Tablets SmPC section 4.2 (eMC product 2639)", "review_status": "reviewed", "verified_against": "Kenalog Intra-articular / Intramuscular Injection (triamcinolone acetonide 40 mg/ml) SmPC sections 4.1 and 4.2 (eMC product 6748), which carries tenosynovitis as a labelled indication: \"For intra-articular administration or injection into tendon sheaths and bursae, the dose of Kenalog Injection may vary from 5 mg to 10 mg (0.125 - 0.25 ml) for smaller joints and up to 40 mg (1.0 ml) for larger joints, depending on the specific disease entity being treated.\" The label's band for a small structure stops at 10 mg while the range given here reaches 20 mg, under the label's 40 mg single-site ceiling. · Naproxen 500 mg Tablets SmPC section 4.2 (eMC product 2639) · AAOS Clinical Practice Guidelines", "verified_date": "2026-08", "treatments": [ { "id": 568, "generic": "Naproxen", "line": 1, "is_adjunct": false, "form": "oral.solid", "strength_mg": 500.0, "adult_dose": "500 mg twice daily with food combined with thumb spica splinting", "adult_duration": "2-4 weeks", "dose_source": "Naproxen 500 mg Tablets SmPC section 4.2 (eMC product 2639)", "rationale": "Non-selective NSAID combined with thumb spica splinting for De Quervain tenosynovitis; it reduces the inflammatory pain of the tendon sheath while the splint rests the affected tendons.", "cautions": [ "Thumb spica splinting of first dorsal compartment is an essential non-pharmacological co-therapy.", "Take with food or co-prescribe PPI in patients at risk for peptic ulceration.", "Contraindicated in active GI bleed, severe heart failure, or CKD." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "Not recommended under 16 years for this indication - the product label restricts paediatric naproxen to juvenile idiopathic arthritis (10 mg/kg/day in two divided doses, child over 5 years). Use paracetamol or ibuprofen instead.", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [ { "trade_name": "ORGOPROXEN 500 MG 20 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ORGANOPHARMA > ORGANO", "price_egp": 16.0, "pack_count": 20, "unit_price": 0.8, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "NAPROSYN 500 MG 10 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MISR > F.HOFFMAN LA ROCHE", "price_egp": 8.05, "pack_count": 10, "unit_price": 0.81, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "NAPROFEN 500MG 10 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EL NILE.", "price_egp": 12.0, "pack_count": 10, "unit_price": 1.2, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "NAPROFEN 500MG 20 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EL NILE.", "price_egp": 24.0, "pack_count": 20, "unit_price": 1.2, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null } ], "condition_id": "de-quervain-tenosynovitis" }, { "id": 569, "generic": "Triamcinolone acetonide", "line": 2, "is_adjunct": false, "form": "injection", "strength_mg": 40.0, "adult_dose": "10-20 mg injected into first dorsal extensor compartment sheath (procedural injection)", "adult_duration": "single dose", "dose_source": "Kenalog Intra-articular / Intramuscular Injection (triamcinolone acetonide 40 mg/ml) SmPC sections 4.1 and 4.2 (eMC product 6748), which carries tenosynovitis as a labelled indication: \"For intra-articular administration or injection into tendon sheaths and bursae, the dose of Kenalog Injection may vary from 5 mg to 10 mg (0.125 - 0.25 ml) for smaller joints and up to 40 mg (1.0 ml) for larger joints, depending on the specific disease entity being treated.\" The label's band for a small structure stops at 10 mg while the range given here reaches 20 mg, under the label's 40 mg single-site ceiling.", "rationale": "High cure rate (>80%) for corticosteroid sheath injection when splinting and oral NSAIDs fail", "cautions": [ "Avoid intratendinous injection (risk of tendon rupture).", "Subcutaneous atrophy and skin depigmentation at injection site can occur.", "A transient post-injection pain flare can occur for 24-48 hours." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "Specialist orthopedic referral required", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [ { "trade_name": "PHARCOCINOLONE 40MG/ML I.M AMP.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "CHEMIPHARM > PHARCO B", "price_egp": 8.0, "pack_count": null, "unit_price": null, "strength_mg": 40.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "AMCINOL 40MG/ML I.M AMP.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "SIGMA TEC", "price_egp": 11.0, "pack_count": null, "unit_price": null, "strength_mg": 40.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "EPIRELEFAN 40MG/ML I.M AMP.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EIPICO", "price_egp": 38.0, "pack_count": null, "unit_price": null, "strength_mg": 40.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "SYNTHECORTIN 40MG/ML I.M AMP.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MUP", "price_egp": 54.0, "pack_count": null, "unit_price": null, "strength_mg": 40.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null } ], "condition_id": "de-quervain-tenosynovitis" } ] }