{ "schema_version": 1, "kind": "condition", "id": "cutaneous-leishmaniasis", "name": "Cutaneous Leishmaniasis", "category": "infectious", "sources": "CDC Yellow Book 2024 · WHO Control of the Leishmaniases Technical Report 2010 · WHO EMRO Manual for case management of cutaneous leishmaniasis in the WHO Eastern Mediterranean Region (2014), p.24, under complex situations", "review_status": "reviewed", "verified_against": "CDC Yellow Book 2024 · WHO Control of the Leishmaniases Technical Report 2010 · WHO EMRO Manual for case management of cutaneous leishmaniasis in the WHO Eastern Mediterranean Region (2014), p.24, under complex situations · Cutaneous Leishmaniasis - disease-level clinical article (cutaneous-leishmaniasis-full.txt)", "verified_date": "2026-08", "treatments": [ { "id": 558, "generic": "Meglumine antimoniate", "line": 1, "is_adjunct": false, "form": "injection", "strength_mg": 85.0, "adult_dose": "Intralesional 0.5-5 mL per session (or 20 mg Sb5+/kg/day IM/IV for 20 days)", "adult_duration": "2-4 weeks under specialist care", "dose_source": "WHO Control of the Leishmaniases Technical Report 2010", "rationale": "Meglumine antimoniate is not available in commercial Egyptian retail pharmacies; pentavalent antimonials are supplied via Ministry of Health/WHO programs.", "cautions": [ "Monitor for cardiotoxicity (QT prolongation) and pancreatitis.", "Unregistered in commercial Egyptian pharmacies; supplied through specialized MOH/WHO programs.", "Requires specialist endemic disease referral; check baseline ECG, renal and pancreatic enzymes if giving IM/IV." ], "peds_mgkg_low": 20.0, "peds_mgkg_high": 20.0, "peds_max_mg": 850.0, "peds_basis": "day", "peds_unit": "mg", "peds_note": "20 mg Sb5+/kg/day IM/IV for 20 days under specialist supervision", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": [ { "weight_kg": 10, "low_mg": 200, "high_mg": 200, "capped": false }, { "weight_kg": 20, "low_mg": 400, "high_mg": 400, "capped": false }, { "weight_kg": 30, "low_mg": 600, "high_mg": 600, "capped": false }, { "weight_kg": 40, "low_mg": 800, "high_mg": 800, "capped": false } ], "brands": [], "condition_id": "cutaneous-leishmaniasis" }, { "id": 559, "generic": "Referral & safety-netting (no drug therapy)", "line": 1, "is_adjunct": false, "form": null, "strength_mg": null, "adult_dose": null, "adult_duration": null, "dose_source": "Leishmaniasis - disease-level clinical article (cutaneous-leishmaniasis-full.txt)", "rationale": "Carries the referral criteria and warning signs for this condition, which apply whichever treatment is chosen.", "cautions": [ "RED FLAG - There is a risk of severe and life-threatening mucosal disease spread." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": null, "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [], "condition_id": "cutaneous-leishmaniasis" }, { "id": 557, "generic": "Fluconazole", "line": 2, "is_adjunct": false, "form": "oral.solid", "strength_mg": 200.0, "adult_dose": "200-600 mg once daily", "adult_duration": "4-6 weeks", "dose_source": "WHO EMRO Manual for case management of cutaneous leishmaniasis in the WHO Eastern Mediterranean Region (2014), p.24, under complex situations", "rationale": "An oral option where the antimonials are not practical. WHO's regional manual is careful about it: the regimen has been proposed for L. major cutaneous leishmaniasis and its efficacy is variable. It sits here as a second choice, which is where that document puts it.", "cautions": [ "WHO EMRO records this regimen as one that has been put forward for L. major cutaneous leishmaniasis while noting that how well it works varies, and lists it under complex situations rather than as a first option.", "Most cutaneous leishmaniasis heals without systemic treatment, leaving a scar. Weigh a six-week azole course against that, particularly for a single small lesion not on the face.", "Contraindicated in pregnancy.", "Intralesional or systemic antimonials (meglumine antimoniate) are standard first-line in specialist centers; fluconazole is an oral alternative for L. major.", "Monitor liver function tests during 6-week course." ], "peds_mgkg_low": 3.0, "peds_mgkg_high": 6.0, "peds_max_mg": 200.0, "peds_basis": "day", "peds_unit": "mg", "peds_note": "3-6 mg/kg once daily for 6 weeks under specialist supervision", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": [ { "weight_kg": 10, "low_mg": 30, "high_mg": 60, "capped": false }, { "weight_kg": 20, "low_mg": 60, "high_mg": 120, "capped": false }, { "weight_kg": 30, "low_mg": 90, "high_mg": 180, "capped": false }, { "weight_kg": 40, "low_mg": 120, "high_mg": 200, "capped": true } ], "brands": [ { "trade_name": "ACTRIAZOLE 200 MG 2 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EGPI > RIGHT CARE PHARMA", "price_egp": 51.5, "pack_count": 2, "unit_price": 25.75, "strength_mg": 200.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "NAVILUCA 200 MG 7 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "INTERNATIONAL DRUG INDUSTRIES > ROTABIOGEN", "price_egp": 255.0, "pack_count": 7, "unit_price": 36.43, "strength_mg": 200.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "FUNGICLEAR 200 MG 2 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EGPI > HEROPHARM", "price_egp": 74.0, "pack_count": 2, "unit_price": 37.0, "strength_mg": 200.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "FUNGICLEAR 200 MG 4 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EGPI > HEROPHARM", "price_egp": 148.0, "pack_count": 4, "unit_price": 37.0, "strength_mg": 200.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "DIFLUNAZOLE 25MG/5ML SYRUP 70ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "CID", "price_egp": 28.8, "pack_count": null, "unit_price": null, "strength_mg": 25.0, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null }, { "trade_name": "FLUCAZONIL 25MG/5ML SYRUP 70 ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EL NILE.", "price_egp": 28.8, "pack_count": null, "unit_price": null, "strength_mg": 25.0, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null } ], "condition_id": "cutaneous-leishmaniasis" } ] }