Dawaa Reference

infectious

Acute croup (laryngotracheobronchitis)

Treatment options, dosing, cautions and Egyptian brands from the shipped Dawaa Reference card.

Evidence status

Checked against the sources named below

Sources4 sources

WHO Pocket Book of Hospital Care for Children 2013 · Egyptian National Drug Formulary - Endocrine System 2024 (dexamethasone monograph) · Budesonide 0.5 mg nebuliser suspension SmPC section 4.2 (eMC product 100358) · Croup - disease-level clinical article (croup-full.txt)

Verified against4 documents
  • Egyptian National Drug Formulary - Endocrine System 2024 (dexamethasone monograph)
  • Budesonide 0.5 mg nebuliser suspension SmPC section 4.2 (eMC product 100358)
  • Croup - disease-level clinical article (croup-clinical.txt)
  • Croup - disease-level clinical article (croup-full.txt)

Verified date2026-08

Presentation reference

Is it this?

Reference only, to read alongside your own examination.

Symptoms — what the patient reports (4)

  • One to two days of runny nose and low-grade fever precede a barking cough, without drooling or trouble swallowing [cough · fever · runny nose]
  • Seal-like barking cough, stridor, and hoarseness that worsen at night [cough · hoarseness · stridor]
  • Agitation worsens stridor, which can occur even at rest [irritability · stridor]
  • Illness typically lasts 3 to 7 days, peaking on day 3 or 4

Signs — what you find (3)

  • Nasal flaring, retractions, and rarely cyanosis suggest severe croup [chest recession · cyanosis]
  • Tachypnea and tachycardia may accompany croup [tachycardia · tachypnoea]
  • A Westley score over 5 warrants hospitalization; a score of 1 to 2 is safe for outpatient discharge

Tests (3)

  • Neck x-ray, when done, may show a steeple sign from tracheal narrowing
  • Blood tests are not routinely recommended since agitation can worsen airway swelling
  • Recurrent croup with a history of intubation in a young child warrants triple endoscopy

If not this — what else fits (7)

  • Epiglottitis lacks a barking cough and shows anxiety out of proportion to the distress
  • Children with epiglottitis sit upright in a tripod position and rarely cough
  • Bacterial tracheitis shows worsening croup symptoms with high fever and a toxic appearance
  • Deep neck space abscess presents with drooling, neck stiffness, and swollen lymph nodes rather than a barking cough
  • Foreign body aspiration causes sudden choking in a previously healthy child
  • Angioedema causes sudden lip and tongue swelling without preceding cold symptoms or fever
  • Structural airway anomalies cause chronic stridor without cold symptoms or fever

Scores

  • Westley croup score — How severe is this croup?

SourceStatPearls "Croup" - disease-level clinical article

Presentation findings are traced to the source above.

Rx: Main treatment | Moderate-to-severe croup - nebulised, with dexamethasone

MAIN TREATMENT - choose one, plus any add-on marked below

1

DEXAMETHASONE

1st line

Strength0.5 mg

Formoral.liquid

Adult dose and duration

Not applicable — croup is an exclusively paediatric condition (see paediatric weight-based dosing) - Single dose

Paediatric dose

0.15-0.6 mg/kg/dose [child max 12 mg]

(0.15 mg/kg single oral dose (or 0.6 mg/kg in severe croup; max 12 mg))

Dose by weight
3kg0.45-1.8 mg/dose
4kg0.6-2.4 mg/dose
5kg0.75-3 mg/dose
6kg0.9-3.6 mg/dose
7kg1.1-4.2 mg/dose
8kg1.2-4.8 mg/dose
9kg1.3-5.4 mg/dose
10kg1.5-6 mg/dose
11kg1.6-6.6 mg/dose
12kg1.8-7.2 mg/dose
13kg1.9-7.8 mg/dose
14kg2.1-8.4 mg/dose
15kg2.2-9 mg/dose
16kg2.4-9.6 mg/dose
17kg2.5-10.2 mg/dose
18kg2.7-10.8 mg/dose
19kg2.9-11.4 mg/dose
20kg3-12 mg/dose
21kg3.1-12 mg/dose (upper capped)
22kg3.3-12 mg/dose (upper capped)
23kg3.4-12 mg/dose (upper capped)
24kg3.6-12 mg/dose (upper capped)
25kg3.8-12 mg/dose (upper capped)
26kg3.9-12 mg/dose (upper capped)
27kg4-12 mg/dose (upper capped)
28kg4.2-12 mg/dose (upper capped)
29kg4.3-12 mg/dose (upper capped)
30kg4.5-12 mg/dose (upper capped)
31kg4.6-12 mg/dose (upper capped)
32kg4.8-12 mg/dose (upper capped)
33kg5-12 mg/dose (upper capped)
34kg5.1-12 mg/dose (upper capped)
35kg5.2-12 mg/dose (upper capped)
36kg5.4-12 mg/dose (upper capped)
37kg5.5-12 mg/dose (upper capped)
38kg5.7-12 mg/dose (upper capped)
39kg5.8-12 mg/dose (upper capped)
40kg6-12 mg/dose (upper capped)
41kg6.1-12 mg/dose (upper capped)
42kg6.3-12 mg/dose (upper capped)
43kg6.5-12 mg/dose (upper capped)
44kg6.6-12 mg/dose (upper capped)
45kg6.8-12 mg/dose (upper capped)
46kg6.9-12 mg/dose (upper capped)
47kg7-12 mg/dose (upper capped)
48kg7.2-12 mg/dose (upper capped)
49kg7.3-12 mg/dose (upper capped)
50kg7.5-12 mg/dose (upper capped)
Choice

Alternatives. Single-dose oral dexamethasone is the standard of care; the entry keeps nebulised budesonide for the child who refuses or vomits the oral dose. Dexamethasone is also far cheaper (4-36 EGP against 106-529).

Dose source

Croup - disease-level clinical article (croup-full.txt): "Dexamethasone doses of 0.15, 0.3, or 0.6 mg/kg appear equally effective; 0.6 mg/kg is the most commonly used dose." The Egyptian formulary dexamethasone entry carries no croup indication and no paediatric mg/kg dosing. The 12 mg per-dose ceiling is not stated in this article.

Why

Single-dose oral corticosteroid dramatically reduces airway edema and hospital admission

Cautions
  • Give single dose immediately upon presentation.
  • Re-evaluate child within 1-2 hours; refer if stridor at rest persists.
  • Caution in active varicella or systemic fungal infection.
Egyptian brands
Egyptian brandManufacturerIndicative price
DEXAMETHASONE 0.1MG/ML SYP. 100 ML? strength differsMEMPHIS4.50 EGP
DELTASONE 0.25MG/5ML SYRUP 120ML? strength differsEL NILE.30.00 EGP
ORAZONE 0.1MG/ML SYRUP 120ML? strength differsARAB DRUG COMPANY (ADCO)36.00 EGP
2

BUDESONIDE

1st line

Strength1 mg

Formoral.inhalation

Adult dose and duration

2 mg single dose via jet nebulizer (alternative to oral dexamethasone) - Dosing can be repeated every 12 hour for a maximum of 36 hours or until clinical improvement.

Paediatric dose

2 mg (=2000 mcg) single nebulized dose via face mask regardless of age/weight

Dose source

Budesonide 0.5 mg nebuliser suspension SmPC section 4.2 (eMC product 100358)

Why

Nebulized corticosteroid alternative when oral route is refused or vomited

Cautions
  • Use jet nebulizer with face mask.
  • Refer to hospital if respiratory distress, chest indrawing, or cyanosis present.
  • Rinse mouth/face after nebulization if possible.
  • 2 mg may be given as one dose or split into two 1 mg doses 30 minutes apart, and repeated every 12 hours for up to 36 hours or until the child improves.
Egyptian brands
Egyptian brandManufacturerIndicative price
BUDELIZER 1 MG/2ML 20 SUSP. AMP. FOR INH.AMRIYA > EUROPEAN EGYPTIAN PHARM. IND.106.50 EGP
LUNGOCORT 1 MG/2ML 20 SUSP. AMP. FOR INH.EVA PHARMA408.00 EGP
BUDEXAN 1 MG/2ML 20 SUSP. AMP. FOR INH.GENETIC S.P.A > AMRIYA529.00 EGP
3

REFERRAL & SAFETY-NETTING (NO DRUG THERAPY)

1st line
Dose source

Croup - disease-level clinical article (croup-clinical.txt)

Why

Carries the referral criteria and warning signs for this condition, which apply whichever treatment is chosen.

Cautions
  • RED FLAG - Parent and caregiver warning signs require immediate emergency evaluation.
  • RED FLAG - Admission or extended observation is needed for severe croup or symptoms persisting after 2+ epinephrine doses.
4

OXYGEN

add-on - not a substitute
Adult dose and duration

Not applicable - croup is a paediatric condition (see paediatric dosing)

Paediatric dose

Any child whose oxygen saturation has fallen is given supplemental oxygen. The article states no flow rate and no target saturation. It does say how to give it: keep the delivery as undisturbing as it can be made, because agitating a child with croup worsens the obstruction, and holding the source near the face - blow-by - may work better than strapping on a mask or nasal cannula.

Dose source

Croup - disease-level clinical article (croup-full.txt)

Why

Severe croup is an airway emergency and the article gives oxygen to every child whose saturation has fallen. It states no flow rate and no target saturation, so the article's own wording is printed rather than a number invented for it. No Egyptian product corresponds to it, which the physician ruled acceptable on 2026-08-16.

Cautions
  • Any agitation can worsen the symptoms - do not force a mask or nasal cannula on a distressed child; blow-by administration may be more effective.
  • Oxygen treats the hypoxia, not the airway obstruction: a child in the moderate or severe range needs prompt treatment aimed at the obstruction itself - racemic epinephrine, a steroid, supportive care, and oxygen only as required.
  • A child needing oxygen for croup needs hospital care - moderate-to-severe cases require observation and admission if the symptoms do not improve.

MODERATE-TO-SEVERE CROUP - NEBULISED, WITH DEXAMETHASONE - give alongside

5

ADRENALINE

Moderate-to-severe croup - nebulised, with dexamethasone

add-on - not a substitute

Strength1 mg

Forminjection

Adult dose and duration

Not applicable - croup is a paediatric condition (see paediatric dosing)

Paediatric dose

0.5 mL/kg/dose

(Approximately 0.5 mL/kg of L-epinephrine 1:1000 (the 1 mg/mL ampoule) by nebuliser, for moderate-to-severe croup. The article states no maximum volume and no maximum number of doses, so none is given here; do not invent one.)

Dose by weight
3kg1.5 mL/dose
4kg2 mL/dose
5kg2.5 mL/dose
6kg3 mL/dose
7kg3.5 mL/dose
8kg4 mL/dose
9kg4.5 mL/dose
10kg5 mL/dose
11kg5.5 mL/dose
12kg6 mL/dose
13kg6.5 mL/dose
14kg7 mL/dose
15kg7.5 mL/dose
16kg8 mL/dose
17kg8.5 mL/dose
18kg9 mL/dose
19kg9.5 mL/dose
20kg10 mL/dose
21kg10.5 mL/dose
22kg11 mL/dose
23kg11.5 mL/dose
24kg12 mL/dose
25kg12.5 mL/dose
26kg13 mL/dose
27kg13.5 mL/dose
28kg14 mL/dose
29kg14.5 mL/dose
30kg15 mL/dose
31kg15.5 mL/dose
32kg16 mL/dose
33kg16.5 mL/dose
34kg17 mL/dose
35kg17.5 mL/dose
36kg18 mL/dose
37kg18.5 mL/dose
38kg19 mL/dose
39kg19.5 mL/dose
40kg20 mL/dose
41kg20.5 mL/dose
42kg21 mL/dose
43kg21.5 mL/dose
44kg22 mL/dose
45kg22.5 mL/dose
46kg23 mL/dose
47kg23.5 mL/dose
48kg24 mL/dose
49kg24.5 mL/dose
50kg25 mL/dose
Dose source

Croup - disease-level clinical article (croup-full.txt)

Why

The card carried dexamethasone, budesonide and oxygen but nothing for the child who is actually struggling. The condition's own article names the drug and gives the amount in the same document: a child with moderate or severe croup receives nebulised epinephrine alongside dexamethasone, and the amount is about 0.5 mL/kg by nebuliser, of the L- form at 1:1000 strength. At 2 hours it outperforms racemic epinephrine, because its effect lasts longer. Named Adrenaline because that is the Egyptian register's spelling; the 1 mg/mL ampoule is the 1:1000 solution the article specifies.

Cautions
  • HOSPITAL OR OBSERVED SETTING ONLY. On the article's account, nebulised racemic epinephrine improves the symptom score within 30 minutes, but in moderate-to-severe croup the effect can fade by 2 hours, so the child must be watched for a prolonged period afterwards. Where the improvement holds, discharge home is possible after 4 hours of observation and instructions to follow up closely. A child nebulised and sent straight home can rebound.
  • Given WITH dexamethasone, not instead of it - the article pairs them for moderate-to-severe croup.
  • Keep the child calm - the article asks for the least invasive route of giving a drug in croup, because agitation of any kind makes the symptoms worse. (Croup - StatPearls - NCBI Bookshelf, NBK431070)
  • The Egyptian formulary's adrenaline monograph covers anaphylaxis, shock, cardiopulmonary resuscitation and bradycardia, not nebulisation for croup, and it states positively that where the situation is life-threatening there is no absolute contraindication to giving epinephrine at all. The croup dose and route above come from the disease article, not from that monograph.
  • Watch for tachycardia, tremor, pallor and hypertension after the dose.
Egyptian brands
Egyptian brandManufacturerIndicative price
EPINEPHRINE-MEMPHIS 1 MG/ML 5 I.M./S.C. AMP.MEMPHIS10.00 EGP
ADRENAMAX 1 MG/1ML 10 AMPS.CHEMIPHARM75.00 EGP
EPINEPHRINE-MISR 1 MG/ML 100 AMP.MISR750.00 EGP
ADRENALINE-CID 1 MG/1ML 100 I.M./S.C. AMP.CID850.00 EGP

Prices are indicative (dataset snapshot 2026-06); verify with the pharmacy.