{ "schema_version": 1, "kind": "condition", "id": "cholera-suspected", "name": "Cholera (Suspected / Secretory Diarrhoea)", "category": "infectious", "sources": "WHO Cholera Outbreak Guidelines 2023 · CDC Yellow Book 2024", "review_status": "reviewed", "verified_against": "WHO Cholera Outbreak Guidelines 2023 · Cholera (Vibrio cholerae Infection) - disease-level clinical article (cholera-suspected-clinical.txt) · MSF Essential Drugs 2024", "verified_date": "2026-08", "treatments": [ { "id": 434, "generic": "ORS", "line": 1, "is_adjunct": false, "form": "oral.liquid", "strength_mg": null, "adult_dose": "Reconstitute 1 sachet in 1 L clean water; drink 1000 mL/hour in severe fluid loss until rehydrated, then replace ongoing stool losses volume-for-volume", "adult_duration": "Until diarrhoea ceases (usually 3-5 days)", "dose_source": "WHO Cholera Outbreak Guidelines 2023", "rationale": "Oral rehydration solution replaces the massive fluid and electrolyte losses of the secretory diarrhoea caused by cholera; rehydration is itself the life-saving treatment here, not an adjunct to one.", "cautions": [ "LIFE-SAVING FIRST LINE: Oral rehydration salts reduce mortality from 50% to <1%.", "Severe dehydration with shock requires IMMEDIATE IV Ringer's Lactate fluid resuscitation.", "Report suspect cases immediately to public health authorities." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "Rehydrate with 75 mL/kg over 4 hours, then replace ongoing purging losses (10-20 mL/kg per loose stool)", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [ { "trade_name": "GLUCOHYDRAN 10 SACHET.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ARAB DRUG COMPANY (ADCO)", "price_egp": 1.75, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "REHYDRAN N 10 SACHET", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "CID", "price_egp": 4.5, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "REHYDRO ZINC 10 SACHETS", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "CID", "price_egp": 7.0, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ORS 20 SACHETS", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "PHAROPHARMA", "price_egp": 40.0, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ELECTRO MASH SYRUP 200 ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MASH PREMIERE", "price_egp": 60.0, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "FLEXOLYTE ORAL REHYDRATION SOL. 240 ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "KEMPETRO FOR CHEMICAL INDUSTRIES", "price_egp": 65.0, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "HERO ORS 200 ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "HERO > HERO MEA TRADING", "price_egp": 120.0, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "SANSO ORS SYRUP 140 ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "AUG PHARMA", "price_egp": 400.0, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null } ], "condition_id": "cholera-suspected" }, { "id": 437, "generic": "Referral & safety-netting (no drug therapy)", "line": 1, "is_adjunct": false, "form": null, "strength_mg": null, "adult_dose": null, "adult_duration": null, "dose_source": "Cholera (Vibrio cholerae Infection) - disease-level clinical article (cholera-suspected-clinical.txt)", "rationale": "Carries the referral criteria and warning signs for this condition, which apply whichever treatment is chosen.", "cautions": [ "RED FLAG - Emergent intravenous rehydration is required for severe dehydration or hypovolemic shock." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": null, "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [], "condition_id": "cholera-suspected" }, { "id": 435, "generic": "Doxycycline", "line": 1, "is_adjunct": true, "form": "oral.solid", "strength_mg": 100.0, "adult_dose": "300 mg single dose", "adult_duration": "single dose", "dose_source": "WHO Cholera Outbreak Guidelines 2023", "rationale": "Single-dose antibiotic therapy reduces stool volume and duration of Vibrio cholerae shedding", "cautions": [ "Antibiotics are ADJUNCT to fluid replacement, never a substitute.", "Contraindicated in pregnancy and children <8 years (use Azithromycin instead). The Egyptian National Drug Formulary - Antimicrobial 2023, doxycycline monograph, sets the same limit: under 8 years the drug is held back for infections that are severe or potentially life-threatening, or for when there is no better alternative to hand." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "Single dose: 2-4 mg/kg (max 300 mg) for children >=8 years; for <8 years give Azithromycin 20 mg/kg single dose", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [ { "trade_name": "FARCODOXIN 100MG 10 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "PHARCO", "price_egp": 11.0, "pack_count": 10, "unit_price": 1.1, "strength_mg": 100.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "DOXY M.R.100 MG 10 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ADWIA", "price_egp": 12.0, "pack_count": 10, "unit_price": 1.2, "strength_mg": 100.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "GRANUDOXY 100MG 10 F.C. TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "GLOBAL NAPI PHARMACEUTICALS > PIERRE FRANCE", "price_egp": 12.0, "pack_count": 10, "unit_price": 1.2, "strength_mg": 100.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "DOXYDOX 100 MG 10 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EIPICO", "price_egp": 23.0, "pack_count": 10, "unit_price": 2.3, "strength_mg": 100.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "DOXYMYCIN 100 MG 10 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EL NILE.", "price_egp": 30.0, "pack_count": 10, "unit_price": 3.0, "strength_mg": 100.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "TABOCINE 100MG 10 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "TABUK PHARMACEUTICAL MANUFACTURING COMPANY > TABUK PHARMA", "price_egp": 46.0, "pack_count": 10, "unit_price": 4.6, "strength_mg": 100.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "VIBRAMYCIN 100MG 10 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "PFIZER", "price_egp": 65.0, "pack_count": 10, "unit_price": 6.5, "strength_mg": 100.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null } ], "condition_id": "cholera-suspected" }, { "id": 436, "generic": "Azithromycin", "line": 2, "is_adjunct": true, "form": "oral.solid", "strength_mg": 500.0, "adult_dose": "1000 mg single dose", "adult_duration": "single dose", "dose_source": "WHO Cholera Outbreak Guidelines 2023", "rationale": "Preferred antibiotic for pregnant women and children under 8 years", "cautions": [ "Azithromycin is the first-line antibiotic choice in pregnant women and young children.", "Take on empty stomach if tolerated." ], "peds_mgkg_low": 20.0, "peds_mgkg_high": 20.0, "peds_max_mg": 1000.0, "peds_basis": "dose", "peds_unit": "mg", "peds_note": "20 mg/kg single dose (max 1000 mg) in children", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": [ { "weight_kg": 10, "low_mg": 200, "high_mg": 200, "capped": false }, { "weight_kg": 20, "low_mg": 400, "high_mg": 400, "capped": false }, { "weight_kg": 30, "low_mg": 600, "high_mg": 600, "capped": false }, { "weight_kg": 40, "low_mg": 800, "high_mg": 800, "capped": false } ], "brands": [ { "trade_name": "AZATRIBACT 500MG 3 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "RIVA PHARMA S.A.E.", "price_egp": 13.5, "pack_count": 3, "unit_price": 4.5, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "GIGAZOCIN 500MG 5 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EGPI > PIONEER", "price_egp": 27.5, "pack_count": 5, "unit_price": 5.5, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "SYSTYMYCIN 500MG 3 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EGPI > NOVELL PHARMA", "price_egp": 21.5, "pack_count": 3, "unit_price": 7.17, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "AZITHROMASH 500 MG 3 F.C. TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MASH PREMIERE", "price_egp": 48.0, "pack_count": 3, "unit_price": 16.0, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "AZALIDE 500MG 3 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "UP PHARMA", "price_egp": 52.0, "pack_count": 3, "unit_price": 17.33, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "AZROLID 500 MG 6 F.C.TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "AMRIYA", "price_egp": 126.0, "pack_count": 6, "unit_price": 21.0, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ZERAMERATE 500 MG", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EGPI > GAMMA PHARMA", "price_egp": 28.5, "pack_count": null, "unit_price": null, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "DISTABCIN 500 MG 3 DISPERSIBLE TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EGPI", "price_egp": 43.5, "pack_count": null, "unit_price": null, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ZITHRODOSE 100MG/5ML SUSP. 15ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EL-OBOUR > AVERROES PHARMA-EGYPT", "price_egp": 12.0, "pack_count": null, "unit_price": null, "strength_mg": 100.0, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null }, { "trade_name": "ZITHROPHATE 200MG/5ML SUSP. 15ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ORGANO PHARMA > NOVELL PHARMA", "price_egp": 12.75, "pack_count": null, "unit_price": null, "strength_mg": 200.0, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null } ], "condition_id": "cholera-suspected" }, { "id": 438, "generic": "Zinc sulfate", "line": 2, "is_adjunct": true, "form": "oral.liquid", "strength_mg": null, "adult_dose": "Child under 6 months: 10 mg once daily for 10 days; Child 6 months to 5 years: 20 mg once daily", "adult_duration": "10 days", "dose_source": "MSF Essential Drugs 2024", "rationale": "Paediatric micronutrient adjunct to oral rehydration solution to reduce duration and severity of acute cholera diarrhoea.", "cautions": [ "Zinc deficiency impairs appetite and immune recovery.", "Give between meals for optimal absorption.", "Complete the full 10-day course even after the diarrhoea stops.", "Egyptian products are zinc sulfate syrups, not the dispersible tablet the guideline describes. Give the stated milligram dose, measured from the strength printed on the bottle." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "Child under 6 months: 10 mg once daily for 10 days. Child from 6 months to 5 years: 20 mg once daily for 10 days (MSF Essential Drugs 2024, zinc sulfate monograph p.339).", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": [ { "label": "Under 6 months", "age_min_months": 0, "age_max_months": 5, "dose_text": "10 mg once daily for 10 days" }, { "label": "6 months to 5 years", "age_min_months": 6, "age_max_months": 71, "dose_text": "20 mg once daily for 10 days" } ], "peds_doses": null, "brands": [ { "trade_name": "ZINC SULFATE 10MG/5ML POWDER FOR SYRUP", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "CID", "price_egp": 5.0, "pack_count": null, "unit_price": null, "strength_mg": 10.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "SALFOVEROSE 20MG/5ML SYRUP 120ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "AVERROES PHARMA-EGYPT", "price_egp": 11.7, "pack_count": null, "unit_price": null, "strength_mg": 20.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ZINCORHEA SYRUP 80 ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "PHARCO", "price_egp": 15.5, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "SULFOZINC 10MG/5ML PD. FOR SUSP. 80ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "CID", "price_egp": 22.0, "pack_count": null, "unit_price": null, "strength_mg": 10.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "SULFOZINC 20MG/5ML SYRUP 80ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "CID", "price_egp": 24.0, "pack_count": null, "unit_price": null, "strength_mg": 20.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ZINCOMIST 10MG/5ML SYRUP 120 ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ORCHIDIA", "price_egp": 50.0, "pack_count": null, "unit_price": null, "strength_mg": 10.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "AGNATIX SYRUP 60 ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ORGANIX > INNOVAKA", "price_egp": 59.0, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ZINCOMEZ 120 ML SYRUP", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ORGANIX > MEZ PHARMA", "price_egp": 85.0, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ZINC-SEDICO 10MG/5ML PD. FOR ORAL SOL.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "SEDICO", "price_egp": 7.0, "pack_count": null, "unit_price": null, "strength_mg": 10.0, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null }, { "trade_name": "ZINC-SEDICO 20MG/5ML PD. FOR ORAL SOL.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "SEDICO", "price_egp": 8.0, "pack_count": null, "unit_price": null, "strength_mg": 20.0, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null } ], "condition_id": "cholera-suspected" } ] }