{ "schema_version": 1, "kind": "condition", "id": "chlamydia-genital", "name": "Genital Chlamydia Infection (Uncomplicated)", "category": "infectious", "sources": "CDC Sexually Transmitted Infections Treatment Guidelines, 2021 (MMWR Recomm Rep 2021;70(4):1-187; PMC8344968), Chlamydial Infections - Chlamydial Infection During Pregnancy, Alternative Regimen, with the amoxicillin dose from Egyptian National Drug Formulary - Antimicrobial 2023, Amoxicillin monograph (printed page 330): \"Immediate release: 500 mg to 1 g every 8 to 12 hours.\" The formulary monograph carries no chlamydia indication; the seven-day course in pregnancy is from the CDC guideline, which is not held in this corpus. · BASHH Clinical Effectiveness Group, Update on the treatment of Chlamydia trachomatis infection, September 2018 · BASHH National Guideline for the Management of Chlamydia trachomatis 2018 · CDC Sexually Transmitted Infections Treatment Guidelines, 2021 (MMWR Recomm Rep 2021;70(4):1-187; PMC8344968), Chlamydial Infections - Chlamydial Infection During Pregnancy, Alternative Regimen · Egyptian National Drug Formulary - Antimicrobial 2023 (ofloxacin monograph)", "review_status": "reviewed", "verified_against": "CDC Sexually Transmitted Infections Treatment Guidelines, 2021 (MMWR Recomm Rep 2021;70(4):1-187; PMC8344968), Chlamydial Infections - Chlamydial Infection During Pregnancy, Alternative Regimen, with the amoxicillin dose from Egyptian National Drug Formulary - Antimicrobial 2023, Amoxicillin monograph (printed page 330): \"Immediate release: 500 mg to 1 g every 8 to 12 hours.\" The formulary monograph carries no chlamydia indication; the seven-day course in pregnancy is from the CDC guideline, which is not held in this corpus. · BASHH Clinical Effectiveness Group, Update on the treatment of Chlamydia trachomatis infection, September 2018 · CDC Sexually Transmitted Infections Treatment Guidelines, 2021 (MMWR Recomm Rep 2021;70(4):1-187; PMC8344968), Chlamydial Infections - Chlamydial Infection During Pregnancy, Alternative Regimen · Chlamydia - disease-level clinical article (chlamydia-genital-clinical.txt)", "verified_date": "2026-08", "treatments": [ { "id": 427, "generic": "Doxycycline", "line": 1, "is_adjunct": false, "form": "oral.solid", "strength_mg": 100.0, "adult_dose": "100 mg twice daily", "adult_duration": "7 days", "dose_source": "BASHH Clinical Effectiveness Group, Update on the treatment of Chlamydia trachomatis infection, September 2018", "rationale": "First line at every site - urogenital, pharyngeal and rectal. Single-dose azithromycin lost that place because it under-treats rectal infection and selects for macrolide resistance in Mycoplasma genitalium, which co-infects 3-15% of these patients.", "cautions": [ "CONTRAINDICATED in pregnancy and breastfeeding. Use the extended azithromycin course on the row below - 1 g then 500 mg daily for 2 days. NOT a 1 g single dose: BASHH withdrew single-dose azithromycin for chlamydia at any site in 2018.", "Take with a full glass of water while sitting or standing upright to prevent severe esophageal ulceration.", "Avoid direct sunlight exposure due to photosensitivity risk.", "Abstain from sexual contact until 7 days after starting treatment and until sexual partners are treated. This one is from the 2015 BASHH chlamydia guideline rather than the 2018 treatment update cited here." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "Not for children under 8 - the Egyptian formulary reserves doxycycline below that age for severe, potentially life-threatening infection. The under-12 cut often quoted is BNF convention rather than a rule from either source here, and note the endemic typhus entry does dose younger children, because a rickettsial illness is exactly the life-threatening case the formulary means. Genital chlamydia is not.", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [ { "trade_name": "FARCODOXIN 100MG 10 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "PHARCO", "price_egp": 11.0, "pack_count": 10, "unit_price": 1.1, "strength_mg": 100.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "DOXY M.R.100 MG 10 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ADWIA", "price_egp": 12.0, "pack_count": 10, "unit_price": 1.2, "strength_mg": 100.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "GRANUDOXY 100MG 10 F.C. TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "GLOBAL NAPI PHARMACEUTICALS > PIERRE FRANCE", "price_egp": 12.0, "pack_count": 10, "unit_price": 1.2, "strength_mg": 100.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "DOXYDOX 100 MG 10 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EIPICO", "price_egp": 23.0, "pack_count": 10, "unit_price": 2.3, "strength_mg": 100.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "DOXYMYCIN 100 MG 10 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EL NILE.", "price_egp": 30.0, "pack_count": 10, "unit_price": 3.0, "strength_mg": 100.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "TABOCINE 100MG 10 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "TABUK PHARMACEUTICAL MANUFACTURING COMPANY > TABUK PHARMA", "price_egp": 46.0, "pack_count": 10, "unit_price": 4.6, "strength_mg": 100.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "VIBRAMYCIN 100MG 10 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "PFIZER", "price_egp": 65.0, "pack_count": 10, "unit_price": 6.5, "strength_mg": 100.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null } ], "condition_id": "chlamydia-genital" }, { "id": 430, "generic": "Referral & safety-netting (no drug therapy)", "line": 1, "is_adjunct": false, "form": null, "strength_mg": null, "adult_dose": null, "adult_duration": null, "dose_source": "Chlamydia - disease-level clinical article (chlamydia-genital-clinical.txt)", "rationale": "Carries the referral criteria and warning signs for this condition, which apply whichever treatment is chosen.", "cautions": [ "RED FLAG - Do a pregnancy test prior to initiating doxycycline therapy, due to the pregnancy contraindication." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": null, "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [], "condition_id": "chlamydia-genital" }, { "id": 428, "generic": "Azithromycin", "line": 2, "is_adjunct": false, "form": "oral.solid", "strength_mg": 500.0, "adult_dose": "1 g orally as a single dose on day 1, followed by 500 mg once daily for 2 days (alternative regimen for pregnant women or tetracycline allergy/intolerance).", "adult_duration": "3 days", "dose_source": "BASHH Clinical Effectiveness Group, Update on the treatment of Chlamydia trachomatis infection, September 2018", "rationale": "For the patient who cannot take a tetracycline - allergy, intolerance, or pregnancy. The old 1 g single dose is no longer recommended for chlamydia at any site. This extended course also covers Mycoplasma genitalium if it is there.", "cautions": [ "Lower microbiological cure than doxycycline in RECTAL infection. BASHH names rectal only - there is no urethral claim in the source.", "Common gastrointestinal side effects include nausea, abdominal pain, and diarrhea.", "In pregnancy the total 2 g course is unlikely to cause harm but the data are thin, and she should be told that. Test of cure is recommended in pregnancy, and no earlier than 3 weeks after treatment in rectal infection." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "Paediatric dosing for genital chlamydia is not addressed in this BASHH adult guideline; specialist paediatric evaluation is required.", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [ { "trade_name": "AZATRIBACT 500MG 3 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "RIVA PHARMA S.A.E.", "price_egp": 13.5, "pack_count": 3, "unit_price": 4.5, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "GIGAZOCIN 500MG 5 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EGPI > PIONEER", "price_egp": 27.5, "pack_count": 5, "unit_price": 5.5, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "SYSTYMYCIN 500MG 3 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EGPI > NOVELL PHARMA", "price_egp": 21.5, "pack_count": 3, "unit_price": 7.17, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "AZITHROMASH 500 MG 3 F.C. TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MASH PREMIERE", "price_egp": 48.0, "pack_count": 3, "unit_price": 16.0, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "AZALIDE 500MG 3 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "UP PHARMA", "price_egp": 52.0, "pack_count": 3, "unit_price": 17.33, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "AZROLID 500 MG 6 F.C.TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "AMRIYA", "price_egp": 126.0, "pack_count": 6, "unit_price": 21.0, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ZERAMERATE 500 MG", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EGPI > GAMMA PHARMA", "price_egp": 28.5, "pack_count": null, "unit_price": null, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "DISTABCIN 500 MG 3 DISPERSIBLE TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EGPI", "price_egp": 43.5, "pack_count": null, "unit_price": null, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ZITHRODOSE 100MG/5ML SUSP. 15ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EL-OBOUR > AVERROES PHARMA-EGYPT", "price_egp": 12.0, "pack_count": null, "unit_price": null, "strength_mg": 100.0, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null }, { "trade_name": "ZITHROPHATE 200MG/5ML SUSP. 15ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ORGANO PHARMA > NOVELL PHARMA", "price_egp": 12.75, "pack_count": null, "unit_price": null, "strength_mg": 200.0, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null } ], "condition_id": "chlamydia-genital" }, { "id": 429, "generic": "Amoxicillin", "line": 3, "is_adjunct": false, "form": "oral.solid", "strength_mg": 500.0, "adult_dose": "500 mg three times daily (alternative regimen in pregnancy)", "adult_duration": "7 days", "dose_source": "CDC Sexually Transmitted Infections Treatment Guidelines, 2021 (MMWR Recomm Rep 2021;70(4):1-187; PMC8344968), Chlamydial Infections - Chlamydial Infection During Pregnancy, Alternative Regimen, with the amoxicillin dose from Egyptian National Drug Formulary - Antimicrobial 2023, Amoxicillin monograph (printed page 330): \"Immediate release: 500 mg to 1 g every 8 to 12 hours.\" The formulary monograph carries no chlamydia indication; the seven-day course in pregnancy is from the CDC guideline, which is not held in this corpus.", "rationale": "Doxycycline is contraindicated in pregnancy; Amoxicillin 500 mg TID for 7 days is an alternative regimen to preferred single-dose Azithromycin in pregnant women (CDC 2021).", "cautions": [ "Test of cure in pregnancy. BASHH recommends one but names no interval; the four-week figure often quoted is convention, and for rectal infection the one interval BASHH does give is no earlier than 3 weeks after treatment ends.", "Contraindicated in patients with severe penicillin hypersensitivity.", "Not a BASHH regimen. BASHH gives pregnant women the extended azithromycin course above; amoxicillin is the CDC alternative, for the patient who can take neither." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "Dosing in infants and young children requires specialist pediatric evaluation.", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [ { "trade_name": "AMOXYCILLIN 500MG 10 CAPS B.P.2013", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ARAB DRUG COMPANY (ADCO)", "price_egp": 6.5, "pack_count": 10, "unit_price": 0.65, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "AMOXICILLIN 500MG 12 CAPS. USP 28", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "OCTOBER PHARMA", "price_egp": 8.1, "pack_count": 12, "unit_price": 0.67, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "AMOXIL 500MG 12 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MUP > SMITHKLINE BEECHAM", "price_egp": 9.0, "pack_count": 12, "unit_price": 0.75, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "AMOXICID 500 MG 12 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "CID", "price_egp": 9.5, "pack_count": 12, "unit_price": 0.79, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "E-MOX 500 MG 16 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EIPICO", "price_egp": 15.6, "pack_count": 16, "unit_price": 0.97, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "HICONCIL 500MG 12 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "PHARCO", "price_egp": 11.6, "pack_count": 12, "unit_price": 0.97, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "BIOMOX 500MG 12 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "SEDICO", "price_egp": 19.5, "pack_count": 12, "unit_price": 1.62, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "IBIAMOX 500 MG 12 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "AMOUN", "price_egp": 45.0, "pack_count": 12, "unit_price": 3.75, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "HICILLIN 125MG/5ML SUSP. 80ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EL NASR", "price_egp": 3.0, "pack_count": null, "unit_price": null, "strength_mg": 125.0, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null }, { "trade_name": "AMOXIL FORT 250MG/5ML SUSP. 60ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MUP > SMITHKLINE BEECHAM", "price_egp": 5.5, "pack_count": null, "unit_price": null, "strength_mg": 250.0, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null } ], "condition_id": "chlamydia-genital" }, { "id": 431, "generic": "Ofloxacin", "line": 3, "is_adjunct": false, "form": "oral.solid", "strength_mg": 300.0, "adult_dose": "300 mg every 12 hours", "adult_duration": "7 days", "dose_source": "Egyptian National Drug Formulary - Antimicrobial 2023 (ofloxacin monograph) - verbatim: \"Cervicitis/urethritis: Oral: Nongonococcal (due to Chlamydia trachomatis) (alternative agent): 300 mg every 12 hours for 7 days\"", "rationale": "The card offers a tetracycline, a macrolide and a penicillin, and nothing for the patient who cannot take any of them. The Egyptian formulary lists chlamydial cervicitis and urethritis under ofloxacin and gives the seven-day dose directly.", "cautions": [ "Do not use in anyone who has reacted to ofloxacin or to any other quinolone.", "Avoid in pregnancy and while breastfeeding - use azithromycin instead.", "Tell the patient to stop the tablets and come back if a tendon becomes painful or swollen.", "The dose has to be spread out or reduced when kidney function is significantly impaired." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "No paediatric dose for chlamydia in the sources opened; this is an adult option.", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [ { "trade_name": "FLOXA WEST 300MG 14 F.C.TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "WESTERN PHARMACEUTICALS INDUSTRIES > WESTERN PHARMA", "price_egp": 19.2, "pack_count": 14, "unit_price": 1.37, "strength_mg": 300.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null } ], "condition_id": "chlamydia-genital" } ] }