{ "schema_version": 1, "kind": "condition", "id": "carpal-tunnel-syndrome", "name": "Carpal Tunnel Syndrome", "category": "chronic", "sources": "AAOS Clinical Practice Guideline on Carpal Tunnel Syndrome 2016 for the indication, with the dose from Egyptian National Drug Formulary - Endocrine System Drugs 2024, Prednisolone monograph (printed pages 169-170): \"Oral: Usual Initial doses: 5 to 60 mg/day given in a single daily dose or in 2 to 4 divided doses.\" The formulary states a general adult range rather than a carpal tunnel regimen; the two-week course is from the AAOS guideline, which is not held in this corpus. · AAOS Clinical Practice Guideline on Carpal Tunnel Syndrome 2016 · Ibuprofen 100 mg/5 ml SmPC section 4.2 (eMC product 4560)", "review_status": "reviewed", "verified_against": "AAOS Clinical Practice Guideline on Carpal Tunnel Syndrome 2016 for the indication, with the dose from Egyptian National Drug Formulary - Endocrine System Drugs 2024, Prednisolone monograph (printed pages 169-170): \"Oral: Usual Initial doses: 5 to 60 mg/day given in a single daily dose or in 2 to 4 divided doses.\" The formulary states a general adult range rather than a carpal tunnel regimen; the two-week course is from the AAOS guideline, which is not held in this corpus. · Ibuprofen 100 mg/5 ml SmPC section 4.2 (eMC product 4560) · AAOS Clinical Practice Guideline on Carpal Tunnel Syndrome 2016 · Carpal Tunnel Syndrome - disease-level clinical article (carpal-tunnel-syndrome-clinical.txt)", "verified_date": "2026-08", "treatments": [ { "id": 377, "generic": "Prednisolone", "line": 1, "is_adjunct": false, "form": "oral.solid", "strength_mg": 20.0, "adult_dose": "20 mg once daily in the morning", "adult_duration": "2 weeks", "dose_source": "AAOS Clinical Practice Guideline on Carpal Tunnel Syndrome 2016 for the indication, with the dose from Egyptian National Drug Formulary - Endocrine System Drugs 2024, Prednisolone monograph (printed pages 169-170): \"Oral: Usual Initial doses: 5 to 60 mg/day given in a single daily dose or in 2 to 4 divided doses.\" The formulary states a general adult range rather than a carpal tunnel regimen; the two-week course is from the AAOS guideline, which is not held in this corpus.", "rationale": "Short course oral corticosteroid that reduces tenosynovial flexor swelling around the median nerve, giving temporary symptom relief in carpal tunnel syndrome while definitive treatment such as injection or decompression is arranged.", "cautions": [ "Short course oral steroid reduces tenosynovial flexor edema.", "Provides temporary relief lasting up to 8-12 weeks.", "Avoid repeated courses; refer for local corticosteroid injection or decompression." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "Specialist paediatric care required", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [ { "trade_name": "UNIPRICORT 20MG 20 ORODISPERSIBLE TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EVA PHARMA", "price_egp": 45.0, "pack_count": null, "unit_price": null, "strength_mg": 20.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "EPICOPRED 20 MG 20 ORODISPERSIBLE TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EIPICO", "price_egp": 104.0, "pack_count": null, "unit_price": null, "strength_mg": 20.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "PREDNISOLONE 20 MG 20 ORODISPERSIBLE TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ARAB DRUG COMPANY (ADCO)", "price_egp": 115.0, "pack_count": null, "unit_price": null, "strength_mg": 20.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "DISPRELONE-D 20MG 20 DISPERSABLE TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EPCI > ANDALOUS PHARMA", "price_egp": 116.0, "pack_count": null, "unit_price": null, "strength_mg": 20.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "SOLUPRED ORO 20 MG 20 ORODISPERSIBLE TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "SANOFI WINTHROP > SANOFI", "price_egp": 142.0, "pack_count": null, "unit_price": null, "strength_mg": 20.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "XILONE 20 MG 20 ORODISPERSABLE TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EUROPEAN EGYPTIAN PHARM. IND.", "price_egp": 142.0, "pack_count": null, "unit_price": null, "strength_mg": 20.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "DISPRELONE-OD 20 MG 30 ORODISPERSABLE TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ANDALOUS PHARMA", "price_egp": 202.5, "pack_count": null, "unit_price": null, "strength_mg": 20.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ACETASEE 1% EYE DROPS (SUSP.) 5 ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "RAMEDA", "price_egp": 7.5, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null }, { "trade_name": "PREDNIS 5MG/5ML SYRUP 100 ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "PHAROPHARMA", "price_egp": 9.5, "pack_count": null, "unit_price": null, "strength_mg": 5.0, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null } ], "condition_id": "carpal-tunnel-syndrome" }, { "id": 378, "generic": "Referral & safety-netting (no drug therapy)", "line": 1, "is_adjunct": false, "form": null, "strength_mg": null, "adult_dose": null, "adult_duration": null, "dose_source": "Carpal Tunnel Syndrome - disease-level clinical article (carpal-tunnel-syndrome-clinical.txt)", "rationale": "Carries the referral criteria and warning signs for this condition, which apply whichever treatment is chosen.", "cautions": [ "RED FLAG - Refer for surgical intervention when conservative treatment fails or CTS is severe on electrophysiological testing." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": null, "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [], "condition_id": "carpal-tunnel-syndrome" }, { "id": 379, "generic": "Methylprednisolone", "line": 2, "is_adjunct": false, "form": "injection", "strength_mg": null, "adult_dose": "20 to 40 mg mixed with 1% lidocaine injected into the carpal tunnel", "adult_duration": null, "dose_source": "Carpal Tunnel Syndrome - disease-level clinical article (carpal-tunnel-syndrome-clinical.txt)", "rationale": "Local corticosteroid injection into the carpal tunnel for temporary reduction of tenosynovial flexor swelling and nerve compression.", "cautions": [ "Strict aseptic technique required to prevent septic arthritis.", "Limit frequency to max 3-4 intra-articular injections per year into the knee to avoid articular cartilage degeneration.", "Contraindicated in systemic infection unless treated; avoid local injection into a previously infected joint.", "Avoid intratendinous injection to prevent extensor tendon atrophy or rupture." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "No paediatric dose is stated in the sources held for this drug.", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [ { "trade_name": "M.P.A 40MG/ML VIAL", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "AMOUN", "price_egp": 8.5, "pack_count": null, "unit_price": null, "strength_mg": 40.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "EPIZOLONE-DEPOT 40MG/ML 1 ML I.M. VIAL", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EIPICO", "price_egp": 39.0, "pack_count": null, "unit_price": null, "strength_mg": 40.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "SOLU-MEDROL 500MG I.M./I.V.VIAL", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "PFIZER", "price_egp": 180.0, "pack_count": null, "unit_price": null, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "GLOBISOLONE 500MG I.V./I.M. LYOPHILIZED POWDER VIAL", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "GLOBAL PHARMACEUTICAL INDUSTRIES", "price_egp": 214.0, "pack_count": null, "unit_price": null, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "SOLU-MEDROL 1GM I.M./I.V.VIAL", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "PFIZER", "price_egp": 360.0, "pack_count": null, "unit_price": null, "strength_mg": 1000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "GLOBISOLONE 1GM I.V./I.M. LYOPHILIZED POWDER VIAL", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "GLOBAL PHARMACEUTICAL INDUSTRIES", "price_egp": 400.0, "pack_count": null, "unit_price": null, "strength_mg": 1000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "METHYLPREDNISOLONE MYLAN 500MG 10 VIALS", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MYLAN S.A.S-FRANCE > RAMCO", "price_egp": 1225.0, "pack_count": null, "unit_price": null, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "METHYLPREDNISOLONE MYLAN 1G 10 VIALS", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MYLAN S.A.S-FRANCE > RAMCO", "price_egp": 2250.0, "pack_count": null, "unit_price": null, "strength_mg": 1000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null } ], "condition_id": "carpal-tunnel-syndrome" }, { "id": 376, "generic": "Ibuprofen", "line": 2, "is_adjunct": true, "form": "oral.solid", "strength_mg": 400.0, "adult_dose": "400 mg 3 times daily with food", "adult_duration": "2-4 weeks", "dose_source": "Ibuprofen 100 mg/5 ml SmPC section 4.2 (eMC product 4560)", "rationale": "Adjunct NSAID added to night splinting for carpal tunnel syndrome; blocks prostaglandin-mediated inflammation to relieve pain, but does not relieve the underlying nerve compression itself.", "cautions": [ "First-line non-pharmacological treatment is neutral wrist splinting at night.", "NSAIDs offer short-term symptom relief but do not change nerve compression.", "Refer for electrodiagnostic testing or surgery if sensory loss/thenar atrophy occurs." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "Extremely rare in children; specialist workup mandatory", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [ { "trade_name": "DAJUANOFEN 400 MG 20 F.C. TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "COPAD PHARMA", "price_egp": 5.0, "pack_count": 20, "unit_price": 0.25, "strength_mg": 400.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "FLABU 400MG 10 F.C.TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "DELTA PHARMA", "price_egp": 3.75, "pack_count": 10, "unit_price": 0.38, "strength_mg": 400.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "NOVA-PROFEN 400MG 30 F.C. TABLETS", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "SANOFI", "price_egp": 12.75, "pack_count": 30, "unit_price": 0.42, "strength_mg": 400.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "IBUPROFEN 400 MG 10 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "SEDICO", "price_egp": 6.0, "pack_count": 10, "unit_price": 0.6, "strength_mg": 400.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "MAFO 400 MG 30 F.C.TABS", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EIPICO", "price_egp": 42.0, "pack_count": 30, "unit_price": 1.4, "strength_mg": 400.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "BRUFEN 400 MG 30 TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "KAHIRA > ABBOTT LABORATORIES", "price_egp": 78.0, "pack_count": 30, "unit_price": 2.6, "strength_mg": 400.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "PROFUSOL 400MG 20 S.G CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EUROPEAN EGYPTIAN PHARM. IND.", "price_egp": 31.0, "pack_count": null, "unit_price": null, "strength_mg": 400.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ANALGIPROF 400 MG 25 SACHETS", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EVA PHARMA", "price_egp": 37.5, "pack_count": null, "unit_price": null, "strength_mg": 400.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "NOVA-PROFEN 100MG/5ML ORAL SUSP. 100ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "SANOFI", "price_egp": 2.25, "pack_count": null, "unit_price": null, "strength_mg": 100.0, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null }, { "trade_name": "BRUFEMOL-N SUSP. 60 ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ARAB DRUG COMPANY (ADCO)", "price_egp": 4.5, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null } ], "condition_id": "carpal-tunnel-syndrome" } ] }