{ "schema_version": 1, "kind": "condition", "id": "bronchiectasis", "name": "Bronchiectasis (Non-CF Exacerbation & Suppression)", "category": "chronic", "sources": "BTS Guideline for Bronchiectasis in Adults 2019", "review_status": "reviewed", "verified_against": "BTS Guideline for Bronchiectasis in Adults 2019 · Egyptian National Drug Formulary - Antimicrobial 2023 (amoxicillin and clavulanate monograph) · Bronchiectasis - disease-level clinical article (bronchiectasis-clinical.txt)", "verified_date": "2026-08", "treatments": [ { "id": 327, "generic": "Amoxicillin + Clavulanic acid", "line": 1, "is_adjunct": false, "form": "oral.solid", "strength_mg": 1000.0, "adult_dose": "875/125 mg twice daily or 500/125 mg three times daily for 10-14 days during acute exacerbation", "adult_duration": "10-14 days", "dose_source": "BTS Guideline for Bronchiectasis in Adults 2019", "rationale": "Broad-spectrum penicillin and beta-lactamase inhibitor combination used to treat an acute bronchiectasis exacerbation, targeting the typical respiratory pathogens found in these damaged airways; paired with chest physiotherapy rather than used alone.", "cautions": [ "CONTRAINDICATED in penicillin/beta-lactam hypersensitivity and in history of co-amoxiclav-associated jaundice or hepatic dysfunction.", "Obtain sputum culture and sensitivity prior to starting antibiotics whenever possible (review against prior microbiology).", "Longer duration (10-14 days) is required compared to uncomplicated bronchitis; airway clearance techniques (chest physiotherapy) are essential concurrent therapy." ], "peds_mgkg_low": 40.0, "peds_mgkg_high": 45.0, "peds_max_mg": 1750.0, "peds_basis": "day", "peds_unit": "mg", "peds_note": "Of amoxicillin component divided BID for 10-14 days under pediatric pulmonology supervision. Ceiling of 1750 mg/day is the Egyptian National Drug Formulary maximum for the 7:1 formulation; the BTS guideline is an adults document and sets no pediatric limit.", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": [ { "weight_kg": 10, "low_mg": 400, "high_mg": 450, "capped": false }, { "weight_kg": 20, "low_mg": 800, "high_mg": 900, "capped": false }, { "weight_kg": 30, "low_mg": 1200, "high_mg": 1350, "capped": false }, { "weight_kg": 40, "low_mg": 1600, "high_mg": 1750, "capped": true } ], "brands": [ { "trade_name": "E-MOXCLAV 1G 10 F.C. TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EIPICO", "price_egp": 14.0, "pack_count": 10, "unit_price": 1.4, "strength_mg": 1000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "JULMENTIN 2X 1GM 15 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "JULPHAR", "price_egp": 57.5, "pack_count": 15, "unit_price": 3.83, "strength_mg": 1000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "DEXICLAVE 1 GM 10 F.C. TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "RAMEDA > NOVELL PHARMA", "price_egp": 38.5, "pack_count": 10, "unit_price": 3.85, "strength_mg": 1000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "MACLAVEX 1 GM 14 F.C.TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MASH PREMIERE", "price_egp": 105.0, "pack_count": 14, "unit_price": 7.5, "strength_mg": 1000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "CLAVIMOX 1 GM 12 F.C.TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "PHARCO", "price_egp": 130.0, "pack_count": 12, "unit_price": 10.83, "strength_mg": 1000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "MEGAMOX 1 GM 14 F.C. TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "AL JAZEERA PHARMACEUTICAL > HIKMA PHARMA", "price_egp": 178.0, "pack_count": 14, "unit_price": 12.71, "strength_mg": 1000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "CLAVOCILLIN 1 GM 10 DISPERSIBLE TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "RAMEDA > ORGANOPHARMA", "price_egp": 106.0, "pack_count": null, "unit_price": null, "strength_mg": 1000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "AUGMENTIN ADULTS 1GM/125MG 12 PWD. ORAL SUSP. SACHETS", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "GLAXO SMITHKLINE", "price_egp": 169.0, "pack_count": null, "unit_price": null, "strength_mg": 1000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "LARYNCLAVE 125/31 PD. FOR ORAL SUSP. 70ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MISR > AL ROWAD PHARMACEUTICAL INDUSTRIAL CO.", "price_egp": 8.0, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null }, { "trade_name": "MEGACLAVOX 156MG/5ML PD. FOR SUSP. 60 ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "CID", "price_egp": 8.0, "pack_count": null, "unit_price": null, "strength_mg": 156.0, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null } ], "condition_id": "bronchiectasis" }, { "id": 328, "generic": "Ciprofloxacin", "line": 1, "is_adjunct": false, "form": "oral.solid", "strength_mg": 500.0, "adult_dose": "500-750 mg twice daily for 14 days when Pseudomonas aeruginosa is isolated or strongly suspected", "adult_duration": "14 days", "dose_source": "BTS Guideline for Bronchiectasis in Adults 2019", "rationale": "Fluoroquinolone with activity against Pseudomonas aeruginosa, reserved for exacerbations where that organism is proven or strongly suspected, since it is not needed for the more typical bronchiectasis pathogens.", "cautions": [ "Reserve exclusively for proven or strongly suspected Pseudomonas aeruginosa exacerbations.", "CONTRAINDICATED in patients with history of fluoroquinolone-induced tendinitis or tendon rupture; discontinue immediately if tendon pain/inflammation occurs.", "Avoid co-administration with oral iron, calcium, dairy, or antacids (chelates and blocks absorption); check for QT prolongation." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "Specialist cystic fibrosis / pediatric pulmonology use only", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [ { "trade_name": "QUINOLOROX 500MG 10 F.C. TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EPCI > ROXXEN", "price_egp": 10.0, "pack_count": 10, "unit_price": 1.0, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ECACIPROFLOX 500 MG 20 F.C. TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "FUTURE PHARMACEUTICAL INDUSTRIES (FPI) > EGYPTIAN CANADIAN PHARMACEUTICAL", "price_egp": 27.0, "pack_count": 20, "unit_price": 1.35, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ELMODOXACIN 500MG 10 F.C.TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EGPI > SEA PHARM", "price_egp": 20.0, "pack_count": 10, "unit_price": 2.0, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "CIPROQUIN 500MG 10 F.C. TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "UNIPHARMA", "price_egp": 50.0, "pack_count": 10, "unit_price": 5.0, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "CIPROFLOXACIN-ORGANO 500 MG 10 F.C.TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ORGANOPHARMA > ORGANO", "price_egp": 63.0, "pack_count": 10, "unit_price": 6.3, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "CIPROFAR 500MG 10 F.C.TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "PHARCO", "price_egp": 69.0, "pack_count": 10, "unit_price": 6.9, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "CIPROMEGA XL 500MG 10 EXT. REL. F.C.TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MASH PREMIERE", "price_egp": 48.0, "pack_count": null, "unit_price": null, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "HEROXACIN 500MG 10 SCORED F.C. TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EGPI > HERO PHARM", "price_egp": 69.0, "pack_count": null, "unit_price": null, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null } ], "condition_id": "bronchiectasis" }, { "id": 330, "generic": "Referral & safety-netting (no drug therapy)", "line": 1, "is_adjunct": false, "form": null, "strength_mg": null, "adult_dose": null, "adult_duration": null, "dose_source": "Bronchiectasis - disease-level clinical article (bronchiectasis-clinical.txt)", "rationale": "Carries the referral criteria and warning signs for this condition, which apply whichever treatment is chosen.", "cautions": [ "RED FLAG - Massive hemoptysis requires urgent bronchial artery embolization or surgery." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": null, "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [], "condition_id": "bronchiectasis" }, { "id": 329, "generic": "Azithromycin", "line": 2, "is_adjunct": true, "form": "oral.solid", "strength_mg": 250.0, "adult_dose": "250 mg once daily 3 days per week (e.g. Mon/Wed/Fri) as long-term anti-inflammatory prophylactic therapy in frequent exacerbators (>=3/year)", "adult_duration": "long-term (6-12 months)", "dose_source": "BTS Guideline for Bronchiectasis in Adults 2019", "rationale": "Macrolide given long-term at reduced, intermittent dosing for its anti-inflammatory rather than antibacterial effect, aimed at cutting how often exacerbations occur in patients who flare frequently; added to, not instead of, standard treatment, and only after nontuberculous mycobacterial infection has been excluded.", "cautions": [ "Must exclude nontuberculous mycobacterial (NTM) infection prior to starting long-term macrolide maintenance.", "Perform baseline ECG (QT interval) and baseline audiometry." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "Specialist pulmonology management only", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [ { "trade_name": "AZATRIBACT 250MG 6 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "RIVA PHARMA S.A.E.", "price_egp": 15.0, "pack_count": 6, "unit_price": 2.5, "strength_mg": 250.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "AZOMYCIN 250MG 6 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "PHARCO", "price_egp": 25.2, "pack_count": 6, "unit_price": 4.2, "strength_mg": 250.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "AZITHROMIN 250MG 6 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EL NILE.", "price_egp": 31.5, "pack_count": 6, "unit_price": 5.25, "strength_mg": 250.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "AZALIDE 250MG 6 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "UP PHARMA", "price_egp": 49.5, "pack_count": 6, "unit_price": 8.25, "strength_mg": 250.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "NEOZOLID 250 MG 6 TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "BORG", "price_egp": 53.0, "pack_count": 6, "unit_price": 8.83, "strength_mg": 250.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "AZI-ONCE 250MG 6 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "JAMJOOM PHARMACEUTICALS", "price_egp": 54.0, "pack_count": 6, "unit_price": 9.0, "strength_mg": 250.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ZITHROMAX 250MG 6 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "PFIZER", "price_egp": 79.0, "pack_count": 6, "unit_price": 13.17, "strength_mg": 250.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "DISTABCIN 250 MG 6 DISPERSIBLE TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EGPI", "price_egp": 43.5, "pack_count": null, "unit_price": null, "strength_mg": 250.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ZITHRODOSE 100MG/5ML SUSP. 15ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EL-OBOUR > AVERROES PHARMA-EGYPT", "price_egp": 12.0, "pack_count": null, "unit_price": null, "strength_mg": 100.0, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null }, { "trade_name": "ZITHROPHATE 200MG/5ML SUSP. 15ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ORGANO PHARMA > NOVELL PHARMA", "price_egp": 12.75, "pack_count": null, "unit_price": null, "strength_mg": 200.0, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null } ], "condition_id": "bronchiectasis" } ] }